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Hua Shan, M.D., Ph.D.

Female  | Languages: English, Chinese

Appointment Phone


Main Location

The Johns Hopkins Hospital

Out-of-State & International Patients +
Out of State Patients

Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

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Call +1-410-502-7683 (7a.m. to 6p.m., EST, Mon-Fri)

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The Johns Hopkins Hospital

Appointment Phone: 410-955-2660

600 N. Wolfe Street
Sheikh Zayed Tower
Baltimore, MD 21287 map



Research Interests

Nucleic acid based donor test (NAT); HCV; HIV; Transfusion-transmitted infections


Dr. Hua Shan is an associate professor of pathology at the Johns Hopkins University School of Medicine. Her clinical practice focuses on Transfusion Medicine and therapeutic apheresis treatments. Her academic interests include providing teaching and training to both domestic and international trainees. Her team conducts research with the aims  to improve both blood safety and avaialbility internationally and to advance the practice of clinical transfusion medicine. 

Dr. Shan received her medical training at Beijing Medical University and the University of Pennsylvania. She completed a recidency in Laboratory Medicine at the Hopsital of University of Pennsylvania. She also completed a fellowship in  Transfusion Medicine at the Hospital of University of Pennsylvania.

She has authored or co-authored numerous peer-reviewed publications and is certified by the American Board of Pathology in Clinical Pathology and Blood Banking and Transfusion Medicine. more

    Additional Information

  • Education +


    • Beijing Medical University / M.D. (1983)


    • Beijing Medical University / Internal Medicine (1984)
    • Hospital of the University of Pennsylvania / Laboratory Medicine (1996)


    • Fox Chase Cancer Center (1992)
    • Fox Chase Cancer Center / Pathology (1992)
    • Hospital of the University of Pennsylvania / Transfusion Medicine (1997)


    • American Board of Pathology / Blood Banking/Transfusion Medicine (2000)
    • American Board of Pathology / Clinical Pathology (1996)
  • Research & Publications +

    Research Summary

    The risk of transfusion transmitted infections (TTI, including HIV, HBV and HCV) has decreased significantly in recent years in developed countries. Unfortunately, many developing countries still have TTI risk levels that are significantly higher than developed countries.

    Dr. Shan has focused her work on developing collaborative research programs with international blood centers with the purpose of identifying ways to improve international blood safety.


    Dr. Shan's reaserch team has carried out donor follow-up case controlled studies in blood centers in Beijing and Urumqi, China to identify risk factors associated with donor HIV and HCV infections. The reported common risk factors among donors in the United States include a history of injection drug abuse (IDU) and a history of blood transfusion before 1990. The lab’s preliminary findings from Chinese blood centers revealed the history of whole blood or plasma donation prior to 1995 as a leading risk factor for both HIV and HCV infections.

    The current donor deferral criteria used at Chinese blood centers does not defer donors with donation history prior to 1995. Based on their findings, the lab is proposing changes to the existing donor deferral criteria to more effectively prevent high-risk donors from entering the donor pool.

    The team has also conducted a multi-blood center study using the nucleic acid based donor test (NAT) to evaluate the prevalence, incidence, and the residual risk level of HIV and HCV in China. They have recently completed a knowledge, attitude and practice (KAP) survey in Urumqi, China to gain better understanding of potential donors in order to develop more effective donor recruitment methods. In addition, they are currently conducting a study in Beijing searching for inexpensive HCV confirmatory methods (instead of the RIBA test, as used in developed countries) that can be used in resource-poor countries. 

    Selected Publications

    1. Shan H, Zhang P. "Viral Attack On Blood Collection: The Experience From Beijing During The SARS Epidemic." Transfusion. 2004; 44:467-469.
    2. Mattis L, Shan H, Powell E, Shirey S, Oliva-Hemker M. "Life threatening ceftriaxone-induced hemolytic anemia in a child with Crohn's disease." Clinical Pediatrics. 2004; 43:175-178.
    3. Shan H, Piwowar-Manning E, Thompson RE, Brooks Jackson J. "HIV-1 plasma RNA level and CD4 cell count in a large urban HIV-1-infected patient population from 1997 to 2000." Int J STD AIDS. 2003 Nov;14(11):740-4.
    4. Shan H, Wang J-X, Ren F-R, Zhang Y-Z, Zhao H-Y, Gao G-J, Ji Y, Ness PM. "Blood Banking in China." The Lancet. 2002. 360(9347):1770-1775.
  • Academic Affiliations & Courses +
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