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Photo of Dr. Edward W Gabrielson, MD

Edward W Gabrielson, MD

Professor of Pathology
Male
Appointment Phone

410-502-5250

Primary Location

The Johns Hopkins Hospital

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Out-of-State & International Patients +
Out of State Patients

Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

Learn more about our out-of-state patient services »

International Patients

Call +1-410-502-0773 (7a.m. to 6p.m., EST, Mon-Fri)

Learn more about our international patient services »

Titles

  • Professor of Pathology
  • Professor of Oncology

Expertise

Breast Cancer, Esophageal Cancer, Lung Cancer, Pathology

Research Interests

biomarkers; lung cancer; breast cancer; esophageal cancer

Languages

  • English

Additional Resources

Additional Resources +
  • Education +

    Training

    • Northwestern University The Feinberg School of Medicine ( Chicago IL ) (1977)

    Residencies

    • University of Colorado School of Medicine/Pathology ( Denver CO ) (1982)

    Fellowships

    • National Institutes of Health/Pathology ( Bethesda MD ) (1985)

    Certifications

    • Anatomic & Clinical Pathology, American Board of Pathology (1983)
  • Research & Publications +

    Selected Publications

    Gabrielson, E. Worldwide trends in lung cancer pathology. Respirology. 2006 Sep;11(5):533-538.

    Mao, T.L.; Hsu, C.Y.; Yen, M.J.; Gilks, B.; Sheu, J.J.; Gabrielson, E.; Vang, R.; Cope, L.; Kurman, R.J.; Wang, T.L.; Shih Ie, M. Expression of Rsf-1, a chromatin-remodeling gene, in ovarian and breast carcinoma. Hum Pathol. 2006 Sep;37(9):1169-1175.

    Singh, A.; Misra, V.; Thimmulappa, R.K.; Lee, H.; Ames, S.; Hoque, M.O.; Herman, J.G.; Baylin, S.B.; Sidransky, D.; Gabrielson, E.; Brock, M.V.; Biswal, S. Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer. PLoS Med. 2006 Oct;3(10):e420.

    Yuan, B.; Xu, Y.; Woo, J.H.; Wang, Y.; Bae, Y.K.; Yoon, D.S.; Wersto, R.P.; Tully, E.; Wilsbach, K.; Gabrielson, E. Increased expression of mitotic checkpoint genes in breast cancer cells with chromosomal instability. Clin Cancer Res. 2006 Jan 15;12(2):405-410.

    Lee, J.S.; Orita, H.; Gabrielson, K.; Alvey, S.; Hagemann, R.L.; Kuhajda, F.P.; Gabrielson, E.; Pomper, M.G. FDG-PET for pharmacodynamic assessment of the fatty acid synthase inhibitor C75 in an experimental model of lung cancer. Pharm Res. 2007 Jun;24(6):1202-1207.

    Orita, H.; Coulter, J.; Lemmon, C.; Tully, E.; Vadlamudi, A.; Medghalchi, S.M.; Kuhajda, F.P.; Gabrielson, E. Selective inhibition of fatty acid synthase for lung cancer treatment. Clin Cancer Res. 2007 Dec 1;13(23):7139-7145.

    Woo, J.H.; Li, D.; Wilsbach, K.; Orita, H.; Coulter, J.; Tully, E.; Kwon, T.K.; Xu, S.; Gabrielson, E. Coix Seed Extract, a Commonly Used Treatment for Cancer in China, Inhibits NFkappaB and Protein Kinase C Signaling. Cancer Biol Ther. 2007 Oct 13;6(12).

    Brock, M.V.; Hooker, C.M.; Ota-Machida, E.; Han, Y.; Guo, M.; Ames, S.; Glockner, S.; Piantadosi, S.; Gabrielson, E.; Pridham, G.; Pelosky, K.; Belinsky, S.A.; Yang, S.C.; Baylin, S.B.; Herman, J.G. DNA methylation markers and early recurrence in stage I lung cancer. N Engl J Med. 2008 Mar 13;358(11):1118-1128.

    Gabrielson, K.L.; Mok, G.S.; Nimmagadda, S.; Bedja, D.; Pin, S.; Tsao, A.; Wang, Y.; Sooryakumar, D.; Yu, S.J.; Pomper, M.G.; Tsui, B.M. Detection of dose response in chronic doxorubicin-mediated cell death with cardiac technetium 99m annexin V single-photon emission computed tomography. Molecular imaging : official journal of the Society for Molecular Imaging. 2008 May-Jun;7(3):132-138.

    Garrett-Mayer, E.; Parmigiani, G.; Zhong, X.; Cope, L.; Gabrielson, E. Cross-study validation and combined analysis of gene expression microarray data. Biostatistics. 2008 Apr;9(2):333-354.

    Moens, A.L.; Takimoto, E.; Tocchetti, C.G.; Chakir, K.; Bedja, D.; Cormaci, G.; Ketner, E.A.; Majmudar, M.; Gabrielson, K.; Halushka, M.K.; Mitchell, J.B.; Biswal, S.; Channon, K.M.; Wolin, M.S.; Alp, N.J.; Paolocci, N.; Champion, H.C.; Kass, D.A. Reversal of cardiac hypertrophy and fibrosis from pressure overload by tetrahydrobiopterin: efficacy of recoupling nitric oxide synthase as a therapeutic strategy. Circulation. 2008 May 20;117(20):2626-2636.

    Orita, H.; Coulter, J.; Tully, E.; Kuhajda, F.P.; Gabrielson, E. Inhibiting fatty acid synthase for chemoprevention of chemically induced lung tumors. Clin Cancer Res. 2008 Apr 15;14:2458-2464.

    Singh, A.; Boldin-Adamsky, S.; Thimmulappa, R.K.; Rath, S.K.; Ashush, H.; Coulter, J.; Blackford, A.; Goodman, S.N.; Bunz, F.; Watson, W.H.; Gabrielson, E.; Feinstein, E.; Biswal, S. RNAi-mediated silencing of nuclear factor erythroid-2-related factor 2 gene expression in non-small cell lung cancer inhibits tumor growth and increases efficacy of chemotherapy. Cancer Res. 2008 Oct 1;68(19):7975-7984.

    Song, H.; Shahverdi, K.; Huso, D.L.; Wang, Y.; Fox, J.J.; Hobbs, R.F.; Gimi, B.; Gabrielson, K.L.; Pomper, M.G.; Tsui, B.M.; Bhujwalla, Z.; Reilly, R.T.; Sgouros, G. An immunotolerant HER-2/neu transgenic mouse model of metastatic breast cancer. Clin Cancer Res. 2008 Oct 1;14(19):6116-6124.

    Sussan, T.E.; Jun, J.; Thimmulappa, R.; Bedja, D.; Antero, M.; Gabrielson, K.L.; Polotsky, V.Y.; Biswal, S. Disruption of Nrf2, a key inducer of antioxidant defenses, attenuates ApoE-mediated atherosclerosis in mice. PLoS ONE. 2008;3(11):e3791.

    Suzuki, H.; Toyota, M.; Carraway, H.; Gabrielson, E.; Ohmura, T.; Fujikane, T.; Nishikawa, N.; Sogabe, Y.; Nojima, M.; Sonoda, T.; Mori, M.; Hirata, K.; Imai, K.; Shinomura, Y.; Baylin, S.B.; Tokino, T. Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer. Br J Cancer. 2008 Mar 25;98(6):1147-1156.

    Takahashi, K.; Miyashita, M.; Makino, H.; Akagi, I.; Orita, H.; Hagiwara, N.; Nomura, T.; Gabrielson, E.W.; Tajiri, T. Expression of Akt and Mdm2 in human esophageal squamous cell carcinoma. Exp Mol Pathol. 2008 Dec 14.

    Balmanoukian, A.; Zhang, Z.; Jeter, S.; Slater, S.; Armstrong, D.K.; Emens, L.A.; Fetting, J.H.; Wolff, A.C.; Davidson, N.E.; Jacobs, L.; Lange, J.; Tsangaris, T.N.; Zellars, R.; Gabrielson, E.; Stearns, V. African American women who receive primary anthracycline- and taxane-based chemotherapy for triple-negative breast cancer suffer worse outcomes compared with white women. J Clin Oncol. 2009 Aug 1;27(22):e35-37; author reply e38-39.

    Sussan, T.E.; Rangasamy, T.; Blake, D.J.; Malhotra, D.; El-Haddad, H.; Bedja, D.; Yates, M.S.; Kombairaju, P.; Yamamoto, M.; Liby, K.T.; Sporn, M.B.; Gabrielson, K.L.; Champion, H.C.; Tuder, R.M.; Kensler, T.W.; Biswal, S. Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice. Proc Natl Acad Sci U S A. 2009 Jan 6;106(1):250-255.

    Takahashi, K.; Miyashita, M.; Makino, H.; Akagi, I.; Orita, H.; Hagiwara, N.; Nomura, T.; Gabrielson, E.W.; Tajiri, T. Expression of Akt and Mdm2 in human esophageal squamous cell carcinoma. Exp Mol Pathol. 2009 Aug;87(1):42-47.

    Blake, D.J.; Singh, A.; Kombairaju, P.; Malhotra, D.; Mariani, T.J.; Tuder, R.M.; Gabrielson, E.; Biswal, S. Deletion of Keap1 in the lung attenuates acute cigarette smoke-induced oxidative stress and inflammation. Am J Respir Cell Mol Biol. 2010 May;42(5):524-536.
    Orita, H.; Coulter, J.; Tully, E.; Abe, M.; Montgomery, E.; Alvarez, H.; Sato, K.; Hino, O.; Kajiyama, Y.; Tsurumaru, M.; Gabrielson, E. High levels of fatty acid synthase expression in esophageal cancers represent a potential target for therapy. Cancer Biol Ther. 2010 Sep;10(6):549-554.

    Peterson, R.A.; Gabrielson, K.L.; Johnson, G.A.; Pomper, M.G.; Coatney, R.W.; Winkelmann, C.T. Continuing Education Course #1: Non-Invasive Imaging as a Problem-Solving Tool and Translational Biomarker Strategy in Toxicologic Pathology. Toxicol Pathol. 2010 Dec 8.

    Stoll, L.M.; Johnson, M.W.; Gabrielson, E.; Askin, F.; Clark, D.P.; Li, Q.K. The utility of napsin-A in the identification of primary and metastatic lung adenocarcinoma among cytologically poorly differentiated carcinomas. Cancer Cytopathol. 2010 Dec 25;118(6):441-449.
    Bhang, H.E.; Gabrielson, K.L.; Laterra, J.; Fisher, P.B.; Pomper, M.G. Tumor-specific imaging through progression elevated gene-3 promoter-driven gene expression. Nat Med. 2011 Jan;17(1):123-129.
  • Academic Affiliations & Courses +
  • Activities & Honors +
  • Videos & Media +
  • Upcoming Events +
  • Contact & Locations +

    Locations

    The Johns Hopkins Hospital
    600 N. Wolfe Street
    Hospital Main Entrance - Sheikh Zayed Tower
    Baltimore, MD 21287
    Phone: 410-502-5250
    Appointment Phone: 410-502-5250
    Location Map
    Johns Hopkins Bayview Medical Center
    4940 Eastern Avenue
    Baltimore, MD 21224
    Phone: 410-502-5250
    Appointment Phone: 410-502-5250
    Location Map

    Department/Division

    • Pathology

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