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Edward W Gabrielson, M.D.

Photo of Dr. Edward W Gabrielson, M.D.

Attending Pathologist, Johns Hopkins Hospital

Professor of Pathology

Male

Expertise: Breast Cancer, Esophageal Cancer, Lung Cancer, Pathology

Research Interests: Breast cancer; Biomarkers; Esophageal cancer; Lung cancer

Locations

The Johns Hopkins Hospital

600 N. Wolfe Street
Sheikh Zayed Tower
Baltimore, MD 21287 map
Phone: 410-955-9790

Background

Dr. Edward W. Gabrielson is a professor of pathology and oncology at the Johns Hopkins University School of Medicine. He specializes in molecular pathology, with particular emphasis on the pathology of breast, esophageal and lung cancers. Dr. Gabrielson serves as the co-director of the graduate program in pathobiology and is a member of the Johns Hopkins Kimmel Cancer Center.

He received his M.D. from Northwestern University in 1977. He conducted a residency in pathology at the University of Colorado School of Medicine in 1982, and completed a fellowship in pathology at the National Institutes of Health in 1985.

Dr. Gabrielson has authored or co-authored numerous peer-reviewed publications, and is board certified in Anatomic and Clinical Pathology.

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Titles

  • Attending Pathologist, Johns Hopkins Hospital
  • Attending Pathologist, Johns Hopkins Bayview Medical Center
  • Professor of Pathology
  • Professor of Oncology

Education

Degrees

  • MD; Medicine, Northwestern University The Feinberg School of Medicine (1977)

Residencies

  • University of Colorado School of Medicine / Pathology (1982)

Fellowships

  • National Institutes of Health / Pathology (1985)

Board Certifications

  • American Board of Pathology / Anatomic & Clinical Pathology (1983)

Additional Training

  • Licensed Physician and Surgeon, State of Maryland (1984, 2016)

Research & Publications

Research Summary

Dr. Gabrielson investigates the molecular biology of breast cancer and lung cancer, emphasizing aspects that have potential clinical significance. Current areas of emphasis include molecular classification of cancers, genetic instability in cancer, and functional changes in cancers related to cell-cell interactions and cellular metabolism.

Lab

Dr. Gabrielson’s lab has researched chromosomal changes in cancers, leading to the recognition that most cancers have an intrinsic instability of their genome. The lab has characterized chromosomal instability in breast cancer, recognizing that cancers with high levels of instability have mitotic spindle damage checkpoint defects. These cells also have unexpectedly high expression of mitotic spindle checkpoint genes, and the lab has investigated how the high expression of these genes is critical for survival of these genetically unstable cancer cells.

The Gabrielson lab also works on cellular metabolism of cancer.  Ongoing investigations include the study of fatty acid metabolism in cancer and the protective functions of the Nrf2 signaling pathway.  We are now also undertaking both laboratory and clinical investigations to determine the therapeutic potential of biguanide drugs in lung cancer therapy.

Finally, the laboratory is a part of a multidisciplinary team investigating the potential for immunotherapy in lung cancer treatment.  By evaluating tissue specimens from patients treated with checkpoint blockade therapy, we hope to develop markers to predict responses to these promising therapies.

Technology Expertise Keywords

Lung cancer; breast cancer; molecular biology; cell biology

Selected Publications

View all on Pubmed

Jhaveri TZ, Woo J, Shang X, Park BH and Gabrielson E. AMP-activated kinase (AMPK) regulates activity of HER2 and EGFR in breast cancer. Oncotarget. 2015; 6(17):14754-14765.

Cheung, K. J., Gabrielson, E., Werb, Z., and Ewald, A. J. Collective invasion in breast cancer requires a conserved basal epithelial program. Cell,155, 1639-1651, 2013

Lemmon, C. R., Woo, J. H., Tully, E., Wilsbach, K., and Gabrielson, E. Nuclear factor-kappaB (NF-kappaB) mediates a protective response in cancer cells treated with inhibitors of fatty acid synthase. J Biol Chem, 286: 31457-31465, 2011.

Daniel J, Coulter J, Woo JH, Wilsbach K, Gabrielson E. High levels of the Mps1 checkpoint protein are protective of aneuploidy in breast cancer cells. Proc Natl Acad Sci U S A; 108: 5384-9, 2011.

Orita, H., Coulter, J., Tully, E., Abe, M., Montgomery, E., Alvarez, H., Sato, K., Hino, O., Kajiyama, Y., Tsurumaru, M., and Gabrielson, E. High levels of fatty acid synthase expression in esophageal cancers represent a potential target for therapy. Cancer Biol Ther, 10: 549-554, 2010.

Academic Affiliations & Courses

Graduate Program Affiliation

Pathology

Cellular and Molecular Medicine

Activities & Honors

Memberships

  • United States and Canadian Academy of Pathology
  • International Association for the Study of Lung Cancer
  • Lungevity Foundation
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