Dr. Ravit's research focuses on characterizing CMV strains and understanding their impact on pathogenesis and outcome of congenital CMV infection. In addition, her laboratory is actively involved in research of novel compounds for CMV therapy.
Her work is funded by the NIH and has been published in several research journals. Dr. Boger is a member of the collaborative anti-viral study group and is a site principal investigator for a clinical trial of valganciclovir in congenital CMV infection.
Dr. Boger's laboratory is working on the identification and development of novel anti-Cytomegalovirus compounds. Their studies also focus on understanding the mechanisms of CMV inhibition by newly identified anti-CMV compounds.
Main research topics in the laboratory include:
- CMV inhibition by artemisinin-derived dimers
- Models of anti-viral combination therapy
- Role of WNT pathway in CMV replication
- CMV recognition by NOD2
Evaluation of the PK and PD of Ganciclovir in Premature Infants Receiving Treatment for CMV Infection (Gan Premie)
Congenital CMV and Hearing Loss in Children up to 4 Years of Age: Treating with Valganciclovir Therapy
Clinical Trial Keywords:
Kapoor A, Forman M, Arav-Boger R. "Activation of nucleotide oligomerization domain 2 (NOD2) by human cytomegalovirus initiates innate immune responses and restricts virus replication." PLoS One. 2014 Mar 26;9(3):e92704. doi: 10.1371/journal.pone.0092704. eCollection 2014.
Cai H, Kapoor A, He R, Venkatadri R, Forman M, Posner GH, Arav-Boger R. "In vitro combination of anti-cytomegalovirus compounds acting through different targets: role of the slope parameter and insights into mechanisms of Action." Antimicrob Agents Chemother. 2014 Feb;58(2):986-94. doi: 10.1128/AAC.01972-13. Epub 2013 Nov 25.
He R, Forman M, Mott BT, Venkatadri R, Posner GH, Arav-Boger R. "Unique and highly selective anticytomegalovirus activities of artemisinin-derived dimer diphenyl phosphate stem from combination of dimer unit and a diphenyl phosphate moiety." Antimicrob Agents Chemother. 2013 Sep;57(9):4208-14. doi: 10.1128/AAC.00893-13. Epub 2013 Jun 17.
Mott BT, He R, Chen X, Fox JM, Civin CI, Arav-Boger R, Posner GH. "Artemisinin-derived dimer phosphate esters as potent anti-cytomegalovirus (anti-CMV) and anti-cancer agents: a structure-activity study." Bioorg Med Chem. 2013 Jul 1;21(13):3702-7. doi: 10.1016/j.bmc.2013.04.027. Epub 2013 Apr 22.
Kapoor A, He R, Venkatadri R, Forman M, Arav-Boger R. "WNT modulating agents inhibit human cytomegalovirus replication." Antimicrob Agents Chemother. 2013 Jun;57(6):2761-7. doi: 10.1128/AAC.00029-13. Epub 2013 Apr 9.