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School of Medicine
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Chiadikaobi Uchendu Onyike, M.B.B.S., M.D.
Director, Frontotemporal Dementia Program
Associate Professor of Psychiatry and Behavioral Sciences
Languages: English, Igbo
Expertise: Adult Psychiatry, Alzheimer's Disease (AD), Amyotrophic Lateral Sclerosis (ALS), Behavioral Disorders in Dementia, Behavioral Medicine, Cognitive Disorders , Creutzfeldt-Jakob Disease, Dementia, Disorders of Executive Function, Disorders of Social Cognition, Frontotemporal Dementias, Geriatric Psychiatry, Neuropsychiatry, Primary Aphasias, Prion Diseases, Psychiatry, Psychiatry and Behavioral Sciences , Young-Onset Dementias ...read more
Research Interests: Epidemiology and nosology of the frontotemporal dementias; primary aphasias and related disorders; Treatment trials in the frontotemporal dementias; Cognition and behavior in amyotrophic lateral sclerosis; Clinicopathologic correlation in the frontotemporal dementias; Social cognition; life participation and burden of care in the frontotemporal dementias ...read more
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The Johns Hopkins Hospital
Appointment Phone: 410-502-2981
600 N. Wolfe Street
Sheikh Zayed Tower Suite 305
Baltimore, MD 21287 map
Dr. Onyike is specialized in neuropsychiatry and focuses on the care of individuals who have mid- and late-life dementias. He is principal investigator or co-investigator of studies focused on the epidemiology and treatment of the frontotemporal dementias, dementia care, apathy and the neuropsychiatry of ALS. He is active in professional and public education programs pertaining to dementia, and serves on the Medical Advisory Committee of the Association for Frontotemporal Degeneration and the Alzheimer Disease and Related Disorders Commission of the State of Maryland. He is a founding member of the International Society for Frontotemporal Dementias.
- Director, Frontotemporal Dementia Program
- Co-Director, Frontotemporal Dementia and Young-Onset Dementias Clinic
- Associate Professor of Psychiatry and Behavioral Sciences
Departments / Divisions
- MD, College of Medicine (1991)
- Johns Hopkins University School of Medicine / Psychiatry (2000)
- Johns Hopkins University School of Medicine (2002)
Research & Publications
Clinical Trial Keywordsmemantine, frontotemporal dementia
Onyike CU, Bonner JO, Lyketsos CG, Treisman GJ. Mania during treatment of chronic hepatitis C with pegylated interferon and ribavirin. Am J Psychiatry 2004, 161(3):429-435.
Politis AM, Vozzella S, Mayer LS, Onyike CU, Baker AS, Lyketsos CG. A randomized, controlled, clinical trial of activity therapy for apathy in patients with dementia residing in long-term care. Int J Geriatric Psychiatry 2004, 19:1087-1094.
Rosenberg PB, Onyike CU, Katz IR, Porsteinsson AP, Mintzer JE, Schneider LS, Rabins PV, Meinert CL, Martin BK, Lyketsos CB for the Depression in Alzheimer Disease Study-2: Clinical application of operationalized criteria for "Depression of Alzheimer Disease". Int J Geriatric Psychiatry 2005, 20:119-127.
Lyketsos CG, Toone L, Tschanz J, Rabins PV, Steinberg M, Onyike CU, Corcoran C, Norton M, Zandi P, Breitner JCS, Welsh-Bohmer K and the Cache County Study Group. A Population-based Study of Medical Co-morbidity in Early Dementia and Cognitive Impairment No Dementia (CIND): Association with Functional and Cognitive Impairment. Am J Geriatric Psychiatry 2005, 13:656-664.
Maust DT, Onyike CU, Sheppard JME, Mayer LS, Samus QM, Brandt J, Rabins PV, Lyketsos CG, Rosenblatt A. Predictors of Caregiver Unawareness and Non-treatment of Dementia among Residents of Assisted Living Facilities: The Maryland Assisted Living Study (MD-AL). Am J Geriatr Psychiatry 2006, 14(8):668-675.
Onyike CU. Cerebrovascular Disease and Dementia. Int Review Psychiatry 2006, 18(5):423-431.
Lee HB, Onyike CU. The Cerebrovascular Disease Basis of Psychiatric Syndromes: A model for the Power of Disease Reasoning in Psychiatry. (Editorial) Int Review Psychiatry 2006, 18(5):391-393.
Leroi I, Samus QM, Rosenblatt A, Onyike CU, Brandt J, Baker AS, Rabins P, Lyketsos C. A comparison of small and large assisted living facilities for the diagnosis and care of dementia: the Maryland Assisted Living Study. Int J Geriatric Psychiatry 2007, 22:224-232.
Onyike CU, Sheppard J-ME, Tschanz JT, Norton MC, Green RC, Steinberg M, Welsh-Bohmer KA, Breitner JC, Lyketsos CG. Epidemiology of Apathy in Older Adults: the Cache County Study. Am J Geriatr Psychiatry 2007, 15(5):365-375.
Lyketsos CG, Samus QM, Baker A, McNabney M, Onyike CU, Mayer LS, Brandt J, Rabins P, Rosenblatt A. Effect of Dementia and Treatment of Dementia on Time to Discharge from Assisted Living Facilities: The Maryland Assisted Living Study. J Am Geriatr Soc 2007, 55:1031-1037.
Tighe SK, Leoutsakos JM, Carlson MC, Onyike CU, Samus Q, Baker A, Brandt J, Rabins PV, Mayer L, Rosenblatt A, Lyketsos CG. The association between activity participation and time to discharge in the assisted living setting. Int J Geriatr Psychiatry 2008, 23(6):586-91.
Rosenblatt A, Samus QM, Onyike CU, Baker AS, McNabney M, Mayer LS, Brandt J, Lyketsos CG. Acetylcholinesterase inhibitors in assisted living: patterns of use and association with retention. Int J Geriatr Psychiatry 2008, 23(2):178-84.
Samus QM, Mayer L, Baker A, McNabney M, Brandt J, Onyike CU, Rabins PV, Lyketsos CG, Rosenblatt A. Characteristics and outcomes for assisted living residents with dementia: comparing dementia-specific care units with non-dementia-specific care units. J Am Geriatr Soc 2008, 56(7):1361-3.
Onyike CU. Neuroleptic discontinuation during dementia care: a recent trial and its implications for practice. Nat Clin Pract Neurol 2008, 4(10):528-9.
Rao V, Spiro JR, Handel S, Onyike CU. Clinical correlates of personality changes associated with traumatic brain injury. J Neuropsychiatry Clin Neurosci 2008, 20(1):118-9.
McNabney MK, Samus QM, Lyketsos CG, Brandt J, Onyike CU, Baker A, Rosenblatt A. The spectrum of medical illness and medication use among residents of assisted living facilities in central Maryland. J Am Med Dir Assoc 2008, 9(8):558-64
Appleby BS, Onyike CU. Early detection of periodic sharp wave complexes on EEG by independent component analysis in patients with Creutzfeldt-Jakob disease. J Clin Neurophysiol 2008, 25(4):239.
Robert P, Onyike CU, Leentjens AF, Dujardin K, Aalten P, Starkstein S, Verhey FR, Yessavage J, Clement JP, Drapier D, Bayle F, Benoit M, Boyer P, Lorca PM, Thibaut F, Gauthier S, Grossberg G, Vellas B, Byrne J. Proposed diagnostic criteria for apathy in Alzheimer's disease and other neuropsychiatric disorders. Eur Psychiatry 2009, 24(2):98-104.
Appleby BS, Appleby KK, Crain BJ, Onyike CU, Wallin MT, Rabins PV. Characteristics of established and proposed sporadic Creutzfeldt-Jakob disease variants. Arch Neurol 2009, 66(2):208-15.
Activities & Honors
- Board of Directors, Alzheimers Association of Greater Maryland
- Medical and Scientific Advisory Board, Alzheimers Association of Greater Maryland
- World Federation of Neurology Research Group on Aphasia and Cognitive Disorders
- Medical Advisory Committee, Association for Frontotemporal Degeneration
- Finance Committee, International Society for Frontotemporal Dementias
- Peripheral and Central Nervous Systems Drugs Advisory Committee, US Food and Drug Administration
- American Academy of Neurology
- American Association for Geriatric Psychiatry
- American Neuropsychiatric Association
- American Psychiatric Association
- International Psychogeriatric Society
- International Society for Frontotemporal Dementias
- International Society to Advance Alzheimer Research and Treatment (ISTAART)
- Maryland Psychiatric Society