Dr. Eshleman's HIV research program includes basic, translational and clinical research. Her basic research program is focused on further defining the genetic diversity of HIV strains and the impact of this diversity on HIV transmission, pathogenesis and response to treatment. Her translational research program is focused on development and validation of assays for HIV analysis, with particular emphasis on assays for HIV drug resistance and analysis of non-subtype B strains. She also coordinates a technology transfer initiative, transferring HIV genotyping technology to international laboratories. Her clinical research program involves participation as a virologist and clinical pathologist in clinical trials for HIV prevention and treatment.
She is the principal investigator and director of the HIV Prevention Trials Network Laboratory, and also participates in clinical trials in the IMPAACT network.
The HIV viruses in infected individuals are genetically diverse and evolve at a rapid rate in response to selective pressures. Dr. Eshleman's laboratory studies HIV diversity and its impact on HIV infection and disease progression. Other areas of interest include the evaluation of interventions for HIV prevention, mother-to-child transmission, and the development of novel laboratory methods for HIV analysis.
- Laeyendecker O, Piwowar-Manning E, Fiamma A, Kulich M, Donnell D, Bassuk D, Mullis CE, Chin C, Swanson P, Hackett J Jr, Clarke W, Marzinke M, Szekeres G, Gray G, Richter L, Alexandre MW, Chariyalertsak S, Chingono A, Celentano DD, Morin SF, Sweat M, Coates T, Eshleman SH. "Estimation of HIV incidence in a large, community-based, randomized clinical trial: NIMH project accept (HIV Prevention Trials Network 043)." PLoS One. 2013 Jul 11;8(7):e68349. doi: 10.1371/journal.pone.0068349. Print 2013.
- James MM, Laeyendecker O, Sun J, Hoover DR, Mullis CE, Cousins MM, Coates T, Moore RD, Kelen GD, Fowler MG, Kumwenda JJ, Mofenson LM, Kumwenda NI, Taha TE, Eshleman SH. "Antibody maturation and viral diversification in HIV-infected women." PLoS One. 2013;8(2):e57350. doi: 10.1371/journal.pone.0057350. Epub 2013 Feb 27.
- Cousins MM, Donnell D, Eshleman SH. "Impact of mutation type and amplicon characteristics on genetic diversity measures generated using a high-resolution melting diversity assay." J Mol Diagn. 2013 Jan;15(1):130-7. doi: 10.1016/j.jmoldx.2012.08.008. Epub 2012 Nov 22.
- Eshleman SH, Hudelson SE, Redd AD, Wang L, Debes R, Chen YQ, Martens CA, Ricklefs SM, Selig EJ, Porcella SF, Munshaw S, Ray SC, Piwowar-Manning E, McCauley M, Hosseinipour MC, Kumwenda J, Hakim JG, Chariyalertsak S, de Bruyn G, Grinsztejn B, Kumarasamy N, Makhema J, Mayer KH, Pilotto J, Santos BR, Quinn TC, Cohen MS, Hughes JP. "Analysis of genetic linkage of HIV from couples enrolled in the HIV Prevention Trials Network 052 trial." J Infect Dis. 2011 Dec 15;204(12):1918-26. doi: 10.1093/infdis/jir651. Epub 2011 Oct 11.
- Fogel J, Li Q, Taha TE, Hoover DR, Kumwenda NI, Mofenson LM, Kumwenda JJ, Fowler MG, Thigpen MC, Eshleman SH. "Initiation of antiretroviral treatment in women after delivery can induce multiclass drug resistance in breastfeeding HIV-infected infants." Clin Infect Dis. 2011 Apr 15;52(8):1069-76. doi: 10.1093/cid/cir008.
Cousins MM, Konikoff J, Laeyendecker O, Celum C, Buchbinder SP, Seage GR, Kirk GC, Moore RD, Mehta SH, Margolick JB, Brown J, Mayer KH, Koblin BA, Wheeler D, Justman JE, Hodder SA, Quinn TC, Brookmeyer R, and Eshleman SH. HIV diversity as a biomarker for HIV incidence estimation: including a high resolution melting diversity assay in a multi-assay algorithm. J Clin Microbiol. 2014; 52:115-121.
Coates TJ, Kulich M, Zelaya CE, Celantano DD, Chariyalertsak S, Chingono A, Gray G, Mbwambo JKK, Morin FS, Richter L, Sweat M, van Rooven H, McGrath N, Fiamma A, Laeyendecker O, Piwowar-Manning E, Szerekes G, Donnell D, and Eshleman SH. Effect of community-based voluntary counselling and testing on HIV incidence and social and behavioural outcomes (NIMH Project Accept; HPTN 043): a cluster-randomised trial. Lancet Global Health. 2014. 2:e267-e277.