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Photo of Dr. Susan Henrietta Eshleman, MD PhD

Susan Henrietta Eshleman, MD PhD

Director, HIV Prevention Trials Network (HPTN) Network Laboratory
Professor of Pathology
Female
Appointment Phone

410-955-2660

Main Location

The Johns Hopkins Hospital

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Titles

  • Director, HIV Prevention Trials Network (HPTN) Network Laboratory
  • Professor of Pathology

Centers & Institutes

  • Comprehensive Transplant Center
  • Global Health, Center for

Expertise

Pathology

Research Interests

Virology; HIV drug resistance; HIV prevention; HIV mother-to-child transmission; HIV diversity; Role of HIV genetic diversity in transmission; HIV disease progression

Biography

Dr. Susan Eshleman is a professor of pathology at the Johns Hopkins University School of Medicine. An internationally recognized HIV antiviral resistance expert, she was part of a team that discovered that HIV treatment with antiretroviral drugs can prevent transmission of the virus; the finding was named "Breakthrough of the Year" for 2011 by the journal Science. Dr. Eshleman serves as the director of the HPTN Network Laboratory.

Dr. Eshleman earned her Ph.D. and M.D. from the University of Pennsylvania. She completed her residency in clinical pathology at the Hospital of the University of Pennsylvania and performed a fellowship in transfusion medicine at the Hospital of the University of Pennsylvania.

Dr. Eshleman's research is focused on HIV diversity and its impact on HIV infection and disease progression. Other areas of interest include the evaluation of interventions for HIV prevention, mother-to-child transmission, and the development of novel laboratory methods for HIV analysis. Most of her team’s studies are performed in the context of national and international clinical trials of HIV treatment and prevention.

Her work has been recognized with several awards, including the Faculty Teaching Award from the Department of Pathology in 2000.

Languages

  • English
Additional Resources +
  • Education +

    Training

    • University of Pennsylvania Health System School of Medicine ( Philadelphia PA) (1987)

    Residencies

    • Hospital of the University of Pennsylvania / Clinical Pathology (Philadelphia PA) (1992)

    Fellowships

    • Hospital of the University of Pennsylvania / Transfusion Medicine (Philadelphia PA) (1993)

    Certifications

    • American Board of Pathology / Blood Banking/Transfusion Medicine (1999)
    • American Board of Pathology / Clinical Pathology (1991)
  • Research & Publications +

    Research Summary

    Dr. Eshleman's HIV research program includes basic, translational and clinical research. Her basic research program is focused on further defining the genetic diversity of HIV strains and the impact of this diversity on HIV transmission, pathogenesis and response to treatment. Her translational research program is focused on development and validation of assays for HIV analysis, with particular emphasis on assays for HIV drug resistance and analysis of non-subtype B strains. She also coordinates a technology transfer initiative, transferring HIV genotyping technology to international laboratories. Her clinical research program involves participation as a virologist and clinical pathologist in clinical trials for HIV prevention and treatment.

    She is the principal investigator and director of the HIV Prevention Trials Network Laboratory, and also participates in clinical trials in the IMPAACT network.

    Selected Publications

    1. Laeyendecker O, Piwowar-Manning E, Fiamma A, Kulich M, Donnell D, Bassuk D, Mullis CE, Chin C, Swanson P, Hackett J Jr, Clarke W, Marzinke M, Szekeres G, Gray G, Richter L, Alexandre MW, Chariyalertsak S, Chingono A, Celentano DD, Morin SF, Sweat M, Coates T, Eshleman SH. "Estimation of HIV incidence in a large, community-based, randomized clinical trial: NIMH project accept (HIV Prevention Trials Network 043)." PLoS One. 2013 Jul 11;8(7):e68349. doi: 10.1371/journal.pone.0068349. Print 2013.
    2. James MM, Laeyendecker O, Sun J, Hoover DR, Mullis CE, Cousins MM, Coates T, Moore RD, Kelen GD, Fowler MG, Kumwenda JJ, Mofenson LM, Kumwenda NI, Taha TE, Eshleman SH. "Antibody maturation and viral diversification in HIV-infected women." PLoS One. 2013;8(2):e57350. doi: 10.1371/journal.pone.0057350. Epub 2013 Feb 27.
    3. Cousins MM, Donnell D, Eshleman SH. "Impact of mutation type and amplicon characteristics on genetic diversity measures generated using a high-resolution melting diversity assay." J Mol Diagn. 2013 Jan;15(1):130-7. doi: 10.1016/j.jmoldx.2012.08.008. Epub 2012 Nov 22.
    4. Eshleman SH, Hudelson SE, Redd AD, Wang L, Debes R, Chen YQ, Martens CA, Ricklefs SM, Selig EJ, Porcella SF, Munshaw S, Ray SC, Piwowar-Manning E, McCauley M, Hosseinipour MC, Kumwenda J, Hakim JG, Chariyalertsak S, de Bruyn G, Grinsztejn B, Kumarasamy N, Makhema J, Mayer KH, Pilotto J, Santos BR, Quinn TC, Cohen MS, Hughes JP. "Analysis of genetic linkage of HIV from couples enrolled in the HIV Prevention Trials Network 052 trial." J Infect Dis. 2011 Dec 15;204(12):1918-26. doi: 10.1093/infdis/jir651. Epub 2011 Oct 11.
    5. Fogel J, Li Q, Taha TE, Hoover DR, Kumwenda NI, Mofenson LM, Kumwenda JJ, Fowler MG, Thigpen MC, Eshleman SH. "Initiation of antiretroviral treatment in women after delivery can induce multiclass drug resistance in breastfeeding HIV-infected infants." Clin Infect Dis. 2011 Apr 15;52(8):1069-76. doi: 10.1093/cid/cir008.

    Lab

    The HIV viruses in infected individuals are genetically diverse and evolve at a rapid rate in response to selective pressures. Dr. Eshleman's laboratory studies HIV diversity and its impact on HIV infection and disease progression. Other areas of interest include the evaluation of interventions for HIV prevention, mother-to-child transmission, and the development of novel laboratory methods for HIV analysis.

  • Academic Affiliations & Courses +
  • Activities & Honors +

    Honors

    Poster Award for Outstanding Content and Presentation, 5th International Workshop on HIV Drug Resistance and Treatment Strategies, 2001

    Faculty Teaching Award, Department of Pathology, The Johns Hopkins University, 2000

    MetPath Fellowship in Laboratory Medicine, MetPath Inc., 1992 - 1993

    ACLPS Young Investigator Award for Excellence in Research, 1992

    Upjohn Achievement Award for Excellence in Biomedical Research, 1987

    Association of M.I.T. Alumnae Senior Academic Award, 1980

    Professional Activities

    Cellular and Molecular Medicine; Pathobiology

  • Videos & Media +
  • Events +
  • Contact & Locations +

    Locations

    The Johns Hopkins Hospital
    600 N. Wolfe Street
    Hospital Main Entrance - Sheikh Zayed Tower
    Baltimore, MD 21287
    Appointment Phone: 410-955-2660
    Location Map
    Johns Hopkins Bayview Medical Center
    4940 Eastern Avenue
    Baltimore, MD 21224
    Appointment Phone: 410-955-2660
    Location Map

    Department/Division

    • Pathology

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