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Pedram Argani, MD

Professor of Pathology
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Primary Location

The Johns Hopkins Hospital

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Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

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Call +1-410-502-0773 (7a.m. to 6p.m., EST, Mon-Fri)

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  • Professor of Pathology
  • Professor of Oncology

Centers & Institutes

  • Sidney Kimmel Comprehensive Cancer Center




  • English
Additional Resources +
  • Education +


    • University of Pennsylvania Health System School of Medicine ( Philadelphia PA ) (1992)


    • Hospital of the University of Pennsylvania/Anatomic Pathology ( Philadelphia PA ) (1995)


    • Memorial Sloan - Kettering Cancer Center ( New York NY ) (1997)
    • Memorial Sloan - Kettering Cancer Center/Oncologic Pathology ( New York NY ) (1996)


    • Anatomic Pathology, American Board of Pathology (1997)
  • Research & Publications +

    Selected Publications

    Fenton, H.; Carlile, B.; Montgomery, E.A.; Carraway, H.; Herman, J.; Sahin, F.; Su, G.H.; Argani, P. LKB1 protein expression in human breast cancer. Appl Immunohistochem Mol Morphol. 2006 Jun;14(2):146-153.

    Gallicchio, L.; Berndt, S.I.; McSorley, M.A.; Newschaffer, C.J.; Thuita, L.W.; Argani, P.; Hoffman, S.C.; Helzlsouer, K.J. Polymorphisms in estrogen-metabolizing and estrogen receptor genes and the risk of developing breast cancer among a cohort of women with benign breast disease. BMC Cancer. 2006;6:173.

    Gallicchio, L.; McSorley, M.A.; Newschaffer, C.J.; Thuita, L.W.; Argani, P.; Hoffman, S.C.; Helzlsouer, K.J. Flame-broiled food, NAT2 acetylator phenotype, and breast cancer risk among women with benign breast disease. Breast Cancer Res Treat. 2006 Sep;99(2):229-233.

    Hansel, D.E.; Meeker, A.K.; Hicks, J.; De Marzo, A.M.; Lillemoe, K.D.; Schulick, R.; Hruban, R.H.; Maitra, A.; Argani, P. Telomere length variation in biliary tract metaplasia, dysplasia, and carcinoma. Mod Pathol. 2006 Jun;19(6):772-779.

    Judson, K.; Argani, P. Intraductal spread by metastatic islet cell tumor (well-differentiated pancreatic endocrine neoplasm) involving the breast of a child, mimicking a primary mammary carcinoma. Am J Surg Pathol. 2006 Jul;30(7):912-918.

    Karakas, B.; Weeraratna, A.; Abukhdeir, A.; Blair, B.G.; Konishi, H.; Arena, S.; Becker, K.; Wood, W., 3rd; Argani, P.; De Marzo, A.M.; Bachman, K.E.; Park, B.H. Interleukin-1 alpha mediates the growth proliferative effects of transforming growth factor-beta in p21 null MCF-10A human mammary epithelial cells. Oncogene. 2006 Sep 7;25(40):5561-5569.

    Lo, P.K.; Mehrotra, J.; D''Costa, A.; Fackler, M.J.; Garrett-Mayer, E.; Argani, P.; Sukumar, S. Epigenetic suppression of secreted frizzled related protein 1 (SFRP1) expression in human breast cancer. Cancer Biol Ther. 2006 Mar;5(3):281-286.

    Swift-Scanlan, T.; Blackford, A.; Argani, P.; Sukumar, S.; Fackler, M.J. Two-color quantitative multiplex methylation-specific PCR. Biotechniques. 2006 Feb;40(2):210-219.

    Wu, X.; Chen, H.; Parker, B.; Rubin, E.; Zhu, T.; Lee, J.S.; Argani, P.; Sukumar, S. HOXB7, a Homeodomain Protein, Is Overexpressed in Breast Cancer and Confers Epithelial-Mesenchymal Transition. Cancer Res. 2006 Oct 1;66(19):9527-9534.

    Agoston, A.T.; Argani, P.; De Marzo, A.M.; Hicks, J.L.; Nelson, W.G. Retinoblastoma pathway dysregulation causes DNA methyltransferase 1 overexpression in cancer via MAD2-mediated inhibition of the anaphase-promoting complex. Am J Pathol. 2007 May;170(5):1585-1593.

    Argani, P.; Olgac, S.; Tickoo, S.K.; Goldfischer, M.; Moch, H.; Chan, D.Y.; Eble, J.N.; Bonsib, S.M.; Jimeno, M.; Lloreta, J.; Billis, A.; Hicks, J.; De Marzo, A.M.; Reuter, V.E.; Ladanyi, M. Xp11 translocation renal cell carcinoma in adults: expanded clinical, pathologic, and genetic spectrum. Am J Surg Pathol. 2007 Aug;31(8):1149-1160.

    Cornblatt, B.S.; Ye, L.; Dinkova-Kostova, A.T.; Erb, M.; Fahey, J.W.; Singh, N.K.; Chen, M.S.; Stierer, T.; Garrett-Mayer, E.; Argani, P.; Davidson, N.E.; Talalay, P.; Kensler, T.W.; Visvanathan, K. Preclinical and clinical evaluation of sulforaphane for chemoprevention in the breast. Carcinogenesis. 2007 Jul;28(7):1485-1490.

    Lee, J.S.; Lo, P.K.; Fackler, M.J.; Argani, P.; Zhang, Z.; Garrett-Mayer, E.; Sukumar, S. A Comparative Study of Korean with Caucasian Breast Cancer Reveals Frequency of Methylation in Multiple Genes Correlates with Breast Cancer in Young, ER, PR-negative Breast Cancer in Korean Women. Cancer Biol Ther. 2007 Apr 23;6:1114*1120.

    Shipitsin, M.; Campbell, L.L.; Argani, P.; Weremowicz, S.; Bloushtain-Qimron, N.; Yao, J.; Nikolskaya, T.; Serebryiskaya, T.; Beroukhim, R.; Hu, M.; Halushka, M.K.; Sukumar, S.; Parker, L.M.; Anderson, K.S.; Harris, L.N.; Garber, J.E.; Richardson, A.L.; Schnitt, S.J.; Nikolsky, Y.; Gelman, R.S.; Polyak, K. Molecular definition of breast tumor heterogeneity. Cancer Cell. 2007 Mar;11(3):259-273.

    Tsuda, M.; Davis, I.J.; Argani, P.; Shukla, N.; McGill, G.G.; Nagai, M.; Saito, T.; Lae, M.; Fisher, D.E.; Ladanyi, M. TFE3 fusions activate MET signaling by transcriptional up-regulation, defining another class of tumors as candidates for therapeutic MET inhibition. Cancer Res. 2007 Feb 1;67(3):919-929.

    Abukhdeir, A.M.; Vitolo, M.I.; Argani, P.; De Marzo, A.M.; Karakas, B.; Konishi, H.; Gustin, J.P.; Lauring, J.; Garay, J.P.; Pendleton, C.; Konishi, Y.; Blair, B.G.; Brenner, K.; Garrett-Mayer, E.; Carraway, H.; Bachman, K.E.; Park, B.H. Tamoxifen-stimulated growth of breast cancer due to p21 loss. Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):288-293.

    Argani, P. Understanding Breast Pathology. The Johns Hopkins Breast Cancer Handbook of Healthcare Professionals. Sudbury: Jones and Bartlett Publishers; 2008. p. 37-58.
    Cao, D.; Polyak, K.; Halushka, M.K.; Nassar, H.; Kouprina, N.; Iacobuzio-Donahue, C.; Wu, X.; Sukumar, S.; Hicks, J.; De Marzo, A.; Argani, P. Serial analysis of gene expression of lobular carcinoma in situ identifies down regulation of claudin 4 and overexpression of matrix metalloproteinase 9. Breast Cancer Res. 2008;10(5):R91.

    Cao, D.; Tsangaris, T.N.; Kouprina, N.; Wu, L.S.; Balch, C.M.; Vang, R.; Argani, P. The superficial margin of the skin-sparing mastectomy for breast carcinoma: factors predicting involvement and efficacy of additional margin sampling. Ann Surg Oncol. 2008 May;15(5):1330-1340.

    Kleer, C.G.; Bloushtain-Qimron, N.; Chen, Y.H.; Carrasco, D.; Hu, M.; Yao, J.; Kraeft, S.K.; Collins, L.C.; Sabel, M.S.; Argani, P.; Gelman, R.; Schnitt, S.J.; Krop, I.E.; Polyak, K. Epithelial and stromal cathepsin K and CXCL14 expression in breast tumor progression. Clin Cancer Res. 2008 Sep 1;14(17):5357-5367.

    Lee, J.S.; Fackler, M.J.; Teo, W.W.; Lee, J.H.; Choi, C.; Park, M.H.; Yoon, J.H.; Zhang, Z.; Argani, P.; Sukumar, S. Quantitative promoter hypermethylation profiles of ductal carcinoma in situ in North American and Korean women: Potential applications for diagnosis. Cancer Biol Ther. 2008 Sep;7(9):1398-1406.

    Molavi, D.; Argani, P. Distinguishing benign dissecting mucin (stromal mucin pools) from invasive mucinous carcinoma. Adv Anat Pathol. 2008 Jan;15(1):1-17.

    Subhawong, A.P.; Subhawong, T.; Nassar, H.; Kouprina, N.; Begum, S.; Vang, R.; Westra, W.H.; Argani, P. Most Basal-like Breast Carcinomas Demonstrate the Same Rb-/p16+ Immunophenotype as the HPV-related Poorly Differentiated Squamous Cell Carcinomas Which They Resemble Morphologically. Am J Surg Pathol. 2008 Oct 17.

    Voltura, A.M.; Tsangaris, T.N.; Rosson, G.D.; Jacobs, L.K.; Flores, J.I.; Singh, N.K.; Argani, P.; Balch, C.M. Nipple-sparing mastectomy: critical assessment of 51 procedures and implications for selection criteria. Ann Surg Oncol. 2008 Dec;15(12):3396-3401.

    Wu, J.M.; Fackler, M.J.; Halushka, M.K.; Molavi, D.W.; Taylor, M.E.; Teo, W.W.; Griffin, C.; Fetting, J.; Davidson, N.E.; De Marzo, A.M.; Hicks, J.L.; Chitale, D.; Ladanyi, M.; Sukumar, S.; Argani, P. Heterogeneity of breast cancer metastases: comparison of therapeutic target expression and promoter methylation between primary tumors and their multifocal metastases. Clin Cancer Res. 2008 Apr 1;14(7):1938-1946.

    Albadine, R.; Wang, W.; Brownlee, N.A.; Toubaji, A.; Billis, A.; Argani, P.; Epstein, J.I.; Garvin, A.J.; Cousi, R.; Schaeffer, E.M.; Pavlovich, C.; Netto, G.J. Topoisomerase II alpha status in renal medullary carcinoma: immuno-expression and gene copy alterations of a potential target of therapy. J Urol. 2009 Aug;182(2):735-740.

    Argani, P.; Aulmann, S.; Karanjawala, Z.; Fraser, R.B.; Ladanyi, M.; Rodriguez, M.M. Melanotic Xp11 translocation renal cancers: a distinctive neoplasm with overlapping features of PEComa, carcinoma, and melanoma. Am J Surg Pathol. 2009 Apr;33(4):609-619.

    Axilbund, J.E.; Argani, P.; Kamiyama, M.; Palmisano, E.; Raben, M.; Borges, M.; Brune, K.A.; Goggins, M.; Hruban, R.H.; Klein, A.P. Absence of germline BRCA1 mutations in familial pancreatic cancer patients. Cancer Biol Ther. 2009 Jan;8(2):131-135.

    Carraway, H.E.; Wang, S.; Blackford, A.; Guo, M.; Powers, P.; Jeter, S.; Davidson, N.E.; Argani, P.; Terrell, K.; Herman, J.G.; Lange, J.R. Promoter hypermethylation in sentinel lymph nodes as a marker for breast cancer recurrence. Breast Cancer Res Treat. 2009 Apr 11;114:315-325.

    Chanjuan, S.; Argani, P. Synchronous primary perianal Paget''s disease and rectal adenocarcinoma: report of a hitherto undescribed phenomenon. Int J Surg Pathol. 2009 Feb;17(1):42-45.

    Cimino, A.; Halushka, M.; Illei, P.; Wu, X.; Sukumar, S.; Argani, P. Epithelial cell adhesion molecule (EpCAM) is overexpressed in breast cancer metastases. Breast Cancer Res Treat. 2009 Dec 11.

    Fackler, M.J.; Rivers, A.; Teo, W.W.; Mangat, A.; Taylor, E.; Zhang, Z.; Goodman, S.; Argani, P.; Nayar, R.; Susnik, B.; Sukumar, S.; Khan, S.A. Hypermethylated genes as biomarkers of cancer in women with pathologic nipple discharge. Clin Cancer Res. 2009 Jun 1;15(11):3802-3811.

    Higgins, J.P.; McKenney, J.K.; Brooks, J.D.; Argani, P.; Epstein, J.I. Recommendations for the reporting of surgically resected specimens of renal cell carcinoma: the Association of Directors of Anatomic and Surgical Pathology. Hum Pathol. 2009 Apr;40(4):456-463.

    Lo, P.K.; Watanabe, H.; Cheng, P.C.; Teo, W.W.; Liang, X.; Argani, P.; Lee, J.S.; Sukumar, S. MethySYBR, a novel quantitative PCR assay for the dual analysis of DNA methylation and CpG methylation density. J Mol Diagn. 2009 Sep;11(5):400-414.

    Martignoni, G.; Pea, M.; Gobbo, S.; Brunelli, M.; Bonetti, F.; Segala, D.; Pan, C.C.; Netto, G.; Doglioni, C.; Hes, O.; Argani, P.; Chilosi, M. Cathepsin-K immunoreactivity distinguishes MiTF/TFE family renal translocation carcinomas from other renal carcinomas. Mod Pathol. 2009 Aug;22(8):1016-1022.

    McDonald, O.G.; Rodriguez, R.; Bergner, A.; Argani, P. Metanephric Stromal Tumor Arising in a Patient With the Neurofibromatosis Type 1 Syndrome. Int J Surg Pathol. 2009 Oct 28.

    Ostrow, K.L.; Park, H.L.; Hoque, M.O.; Kim, M.S.; Liu, J.; Argani, P.; Westra, W.; Van Criekinge, W.; Sidransky, D. Pharmacologic unmasking of epigenetically silenced genes in breast cancer. Clin Cancer Res. 2009 Feb 15;15(4):1184-1191.

    Sausville, J.E.; Hernandez, D.J.; Argani, P.; Gearhart, J.P. Pediatric renal cell carcinoma. J Pediatr Urol. 2009 Aug;5(4):308-314.

    Shi, C.; Chandrasekaran, A.; Thuluvath, P.J.; Karikari, C.; Argani, P.; Goggins, M.; Maitra, A.; Eshleman, J.R. Ultrasensitive detection of KRAS2 mutations in bile and serum from patients with biliary tract carcinoma using LigAmp technology. J Mol Diagn. 2009 Nov;11(6):583-589.

    Subhawong, A.P.; Heaphy, C.M.; Argani, P.; Konishi, Y.; Kouprina, N.; Nassar, H.; Vang, R.; Meeker, A.K. The alternative lengthening of telomeres phenotype in breast carcinoma is associated with HER-2 overexpression. Mod Pathol. 2009 Nov;22(11):1423-1431.

    Subhawong, A.P.; Subhawong, T.; Nassar, H.; Kouprina, N.; Begum, S.; Vang, R.; Westra, W.H.; Argani, P. Most basal-like breast carcinomas demonstrate the same Rb-/p16+ immunophenotype as the HPV-related poorly differentiated squamous cell carcinomas which they resemble morphologically. Am J Surg Pathol. 2009 Feb;33(2):163-175.

    Cimino, A.; Halushka, M.; Illei, P.; Wu, X.; Sukumar, S.; Argani, P. Epithelial cell adhesion molecule (EpCAM) is overexpressed in breast cancer metastases. Breast Cancer Res Treat. 2010 Oct;123(3):701-708.

    Gupta, R.A.; Shah, N.; Wang, K.C.; Kim, J.; Horlings, H.M.; Wong, D.J.; Tsai, M.C.; Hung, T.; Argani, P.; Rinn, J.L.; Wang, Y.; Brzoska, P.; Kong, B.; Li, R.; West, R.B.; van de Vijver, M.J.; Sukumar, S.; Chang, H.Y. Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature. 2010 Apr 15;464(7291):1071-1076.

    Jacobs, M.A.; Stearns, V.; Wolff, A.C.; Macura, K.; Argani, P.; Khouri, N.; Tsangaris, T.; Barker, P.B.; Davidson, N.E.; Bhujwalla, Z.M.; Bluemke, D.A.; Ouwerkerk, R. Multiparametric magnetic resonance imaging, spectroscopy and multinuclear ((2)(3)Na) imaging monitoring of preoperative chemotherapy for locally advanced breast cancer. Acad Radiol. 2010 Dec;17(12):1477-1485.

    Lewis, G.H.; Subhawong, A.P.; Nassar, H.; Vang, R.; Illei, P.; Park, B.H.; Argani, P. Relationships between Molecular Subtype of Invasive Breast Carcinoma (IBC) and Expression of Gross Cystic Disease Fluid Protein 15 (GCDFP) and Mammaglobin (MGB). American Journal of Clinical Pathology. 2010;In Press.

    Lo, P.K.; Lee, J.S.; Liang, X.; Han, L.; Mori, T.; Fackler, M.J.; Sadik, H.; Argani, P.; Pandita, T.K.; Sukumar, S. Epigenetic inactivation of the potential tumor suppressor gene FOXF1 in breast cancer. Cancer Res. 2010 Jul 15;70(14):6047-6058.

    Ohm, J.E.; Mali, P.; Van Neste, L.; Berman, D.M.; Liang, L.; Pandiyan, K.; Briggs, K.J.; Zhang, W.; Argani, P.; Simons, B.; Yu, W.; Matsui, W.; Van Criekinge, W.; Rassool, F.V.; Zambidis, E.; Schuebel, K.E.; Cope, L.; Yen, J.; Mohammad, H.P.; Cheng, L.; Baylin, S.B. Cancer-related epigenome changes associated with reprogramming to induced pluripotent stem cells. Cancer Res. 2010 Oct 1;70(19):7662-7673.

    Wu, J.M.; Halushka, M.K.; Argani, P. Intratumoral heterogeneity of HER-2 gene amplification and protein overexpression in breast cancer. Hum Pathol. 2010 Jun;41(6):914-917.

    Heaphy, C.M.; Subhawong, A.P.; Gross, A.L.; Konishi, Y.; Kouprina, N.; Argani, P.; Visvanathan, K.; Meeker, A.K. Shorter telomeres in luminal B, HER-2 and triple-negative breast cancer subtypes. Mod Pathol. 2011 Nov 5;24(2):194-200.
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    The Johns Hopkins Hospital
    600 N. Wolfe Street
    Hospital Main Entrance - Sheikh Zayed Tower
    Baltimore, MD 21287
    Appointment Phone: 410-955-2660
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