Dr. Persaud’s research focuses on the mechanisms of HIV persistence in reservoirs in children. She studies the selection and transmission of drug-resistant HIV during chemoprophylaxis for prevention of mother-to-child transmission and their implications for antiretroviral therapy. She also focuses on therapeutic HIV vaccines and the development of field-friendly assays for infant diagnosis and drug-resistance testing.
Luzuriaga K, Gay H, Ziemniak C, Sanborn KB, Somasundaran M, Rainwater-Lovett K, Mellors JW, Rosenbloom D, Persaud D. "Viremic relapse after HIV-1 remission in a perinatally infected child." N Engl J Med. 2015 Feb 19;372(8):786-8. doi: 10.1056/NEJMc1413931.
Rainwater-Lovett K, Luzuriaga K, Persaud D. "Very early combination antiretroviral therapy in infants: prospects for cure." Curr Opin HIV AIDS. 2015 Jan;10(1):4-11
Persaud D, Patel K, Karalius B, Rainwater-Lovett K, Ziemniak C, Ellis A, Chen YH, Richman D, Siberry GK, Van Dyke RB, Burchett S, Seage GR 3rd, Luzuriaga K; Pediatric HIV/AIDS Cohort Study. "Influence of age at virologic control on peripheral blood human immunodeficiency virus reservoir size and serostatus in perinatally infected adolescents." JAMA Pediatr. 2014 Dec;168(12):1138-46. doi: 10.1001/jamapediatrics.2014.1560. Erratum in: JAMA Pediatr. 2015 Jan;169(1):96
Shah SK, Persaud D, Wendler DS, Taylor HA, Gay H, Kruger M, Grady C. "Research on very early ART in neonates at risk of HIV infection." Lancet Infect Dis. 2014 Sep;14(9):797. doi: 10.1016/S1473-3099(14)70893-X.
Clarke DF, Acosta EP, Rizk ML, Bryson YJ, Spector SA, Mofenson LM, Handelsman E, Teppler H, Welebob C, Persaud D, Cababasay MP, Wang J, Mirochnick M; International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) P1097 Study Team. "Raltegravir pharmacokinetics in neonates following maternal dosing." J Acquir Immune Defic Syndr. 2014 Nov 1;67(3):310-5.