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Juan R Carhuapoma, MD

Interim Director, Division of Neurosciences Critical Care
Associate Professor of Neurology

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The Johns Hopkins Hospital

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  • Interim Director, Division of Neurosciences Critical Care
  • Associate Professor of Neurology
  • Associate Professor of Anesthesiology and Critical Care Medicine
  • Associate Professor of Neurological Surgery


Critical Care, Critical Care Medicine, Intracerebral Hemorrhage, Intracranial Hypertension, Subarachnoid Hemorrhage, Traumatic Brain Injury

Additional Resources +
  • Education +


    • Programa Academico De Medicina (Lima) (1991)


    • Henry Ford Hospital / Neurology (Detroit MI ) (1997)


    • Johns Hopkins University School of Medicine / Neurological Critical Care (Baltimore MD ) (1999)
  • Research & Publications +

    Research Summary

    Dr. J. Ricardo Carhuapoma’s overall research interests include three areas: (1) the role of pharmacologic neuroprotection of perihematoma tissue following intracerebral hemorrhage (ICH); (2) the different hemodynamic and metabolic aspects of neuronal blood flow and metabolism under physiologic conditions and after acute brain injury, as well as their significance in neurologic outcome; and (3) the use of advanced MRI techniques in the study and understanding of ongoing neuronal damage after brain injury to design and assess therapies used in neurologic critical care.

    To investigate these areas, Dr. Carhuapoma is engaged in a number of studies. The first explores the safety and feasibility of thrombolysis with ultrasound in the treatment of ICH and intraventricular hemorrhage (known as the SLEUTH study).

    In another study, Dr. Carhuapoma and his colleagues are investigating removal of an ICH with minimally invasive surgery and treatment with recombinant tissue plasminogen activator (rtPA). The goal of this study is to provide novel safety data that will change the way in which ICHs are treated, including previously unavailable data about the safety, efficacy, and pharmacokinetics of rtPA, as well as MIS data regarding the validity and safety of patient selection, quantitation of surgical effectiveness, patient stability, and disease/treatment-related complications. The study results also will provide the first estimates of the relationship between initial disease severity and long-term outcome for ICH. These data are critical to reducing brain injury from the only stroke subtype for which no adequate treatment is available.

    In a study supported by the Food & Drug Administration, Dr. Carhuapoma and his colleagues are conducting a multicentered clinical trial of thrombolysis for intraventricular hemorrhage, the results of which will allow for the development of an effective treatment for intraventricular hemorrhage and demonstrate the safety and efficacy of thrombolysis with rtPA for that type of stroke.

    Selected Publications View all on PubMed

    Mould WA, Carhuapoma JR (Mould and Carhuapoma contributed equally to this paper as first authors, as acknowledged in the publication), Muschelli J, Lane K, Morgan TC, McBee NA, Bistran-Hall AJ, Ullman NL, Vespa P, Martin NA, Awad I, Zuccarello M, Hanley DF, MISTIE Investigators. Minimally Invasive Surgery Plus Recombinant Tissue-type Plasminogen Activator for Intracerebral Hemorrhage Evacuation Decreases Perihematomal Edema. Stroke. 2013 Mar;44(3):627-34

    Chang TR, Kowalski RG, Caserta F, Carhuapoma JR, Tamargo RJ, Naval NS. Impact of Acute Cocaine Use on Aneurysmal Subarachnoid Hemorrhage. Stroke. 2013 May 7

    Naval NS, Kowalski RG, Chang TR, Caserta F, Carhuapoma JR, Tamargo RJ. The SAH Score: A Comprehensive Communication Tool. J Stroke Cerebrovasc Dis. 2013 October 5

    Kowalski RG, Chang TR, Carhuapoma JR, Tamargo RJ, Naval NS. Withdrawal of technological life support following subarachnoid hemorrhage. Neurocrit Care. 2013; 19: 269-75

    Barnes B, Hanley DF, Carhuapoma JR. Minimally invasive surgery for intracerebral haemorrhage. Curr Opin Crit Care. 2014 February 16.


    Dr. J. Ricardo Carhuapoma’s Lab

  • Academic Affiliations & Courses +
  • Activities & Honors +

    Professional Activities

    Neurocritical Care Society

    American Heart Association Stroke Council

    Society of Critical Care Medicine

    Society of Neurosurgical Anesthesia and Critical Care

    American Academy of Neurology

    Neurocritical Care Society

  • Videos & Media +
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  • Contact & Locations +


    The Johns Hopkins Hospital
    600 N. Wolfe Street
    Sheikh Zayed Tower
    Baltimore, MD 21287
    Phone: 410-955-7481
    Appointment Phone: 410-955-7481
    Fax: 410-614-7903
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    • Anesthesiology and Critical Care Medicine - Neurosciences Critical Care

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