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Patrizio Caturegli, M.D., M.P.H.

Photo of Dr. Patrizio Caturegli, M.D., M.P.H.

Director, Hypophysitis Center

Associate Professor of Pathology

Male

Languages: English, Italian, Spanish

Expertise: Pathology

Research Interests: Thyroid peroxidase (TPO); Thyroglobulin; Autoantibodies; Hurthle cell lesions; Congenital complete heart block; Sjogren's syndrome; Hypophysitis; Thyroiditis; Myocarditis; Endocrinology; Pituitary disease; Thyroid disease; Autoimmune disease ...read more

Locations

The Johns Hopkins Hospital

600 N. Wolfe Street
Sheikh Zayed Tower
Baltimore, MD 21287 map
Phone: 410-955-9790

Background

Dr. Patrizio P. Caturegli is an associate professor of pathology at the Johns Hopkins University School of Medicine. An immunopathologist, Dr. Caturegli is the director of the Johns Hopkins Hypophysitis Center and serves on the faculty of the Autoimmune Disease Research Center.

His clinical and research focus is autoimmune diseases of the endocrine glands. These include myocarditis, thyroiditis, hypophysitis, Sjogren''s syndrome, and complete congenital heart blockage.

Dr. Caturegli earned his medical degree from Italy’s Faculty of Medicine E Chirurgua University of Pisa. He completed a residency in endocrinology at the University of Pisa and a residency in pathology at Johns Hopkins. He performed a fellowship in public health at Johns Hopkins where he also earned a M.P.H. from Hopkins’ Bloomberg School of Public Health. He joined the Johns Hopkins faculty in 1999.

He is American Board of Pathology-certified in clinical pathology and has published more than 100 journal articles.

...read more

Titles

  • Director, Hypophysitis Center
  • Associate Professor of Pathology
  • Joint Appointment in Medicine

Departments / Divisions

Education

Degrees

  • MD, Faculty Of Medicine E Chirurgua University Of Pisa (1987)

Residencies

  • University of Pisa / Endocrinology (1993)
  • Johns Hopkins University School of Medicine / Pathology (1998)

Board Certifications

  • American Board of Pathology / Clinical Pathology (1999)

Research & Publications

Research Summary

Dr. Caturegli’s research focuses on autoimmune diseases of the endocrine glands, with particular focus on those affecting the thyroid and pituitary.

His team has shown that transgenic mice expressing interferon-gamma specifically in the thyroid gland develop a metaplastic transformation of the thyrocyte resembling the human Hürthle cell, a cell characteristically found in Hashimoto thyroiditis.

This transformation depends upon the overexpression of the immunoproteasome—specifically, its LMP2 subunit.

Our team is now evaluating the efficacy of new immunoproteasome inhibitors for the treatment of Hürthle cell lesions.

In the pituitary model, studies have led to the development of a mouse model of autoimmune hypophysitis, a model the lab is using to explore two aspects relevant to human health: 

  • The identification of the pituitary antigens recognized by the immune system in patients with hypophysitis 
  • The recently reported association between hypophysitis and treatments used in patients with cancer to block T cell inhibitory signals, such as CTLA-4

Selected Publications

  1. De Remigis A, de Gruijl TD, Uram JN, Tzou SC, Iwama S, Talor MV, Armstrong TD, Santegoets SJ, Slovin SF, Zheng L, Laheru DA, Jaffee EM, Gerritsen WR, van den Eertwegh AJ, Le DT, Caturegli P. "Development of thyroglobulin antibodies after GVAX immunotherapy is associated with prolonged survival." Int J Cancer. 2014 May 15. doi: 10.1002/ijc.28973. [Epub ahead of print]
  2. McLeod DS, Caturegli P, Cooper DS, Matos PG, Hutfless S. "Variation in rates of autoimmune thyroid disease by race/ethnicity in US military personnel." JAMA. 2014 Apr 16;311(15):1563-5. doi: 10.1001/jama.2013.285606. No abstract available.
  3. Iwama S, De Remigis A, Callahan MK, Slovin SF, Wolchok JD, Caturegli P. "Pituitary expression of CTLA-4 mediates hypophysitis secondary to administration of CTLA-4 blocking antibody." Sci Transl Med. 2014 Apr 2;6(230):230ra45. doi: 10.1126/scitranslmed.3008002.
  4. Ricciuti A, De Remigis A, Landek-Salgado MA, De Vincentiis L, Guaraldi F, Lupi I, Iwama S, Wand GS, Salvatori R, Caturegli P. "Detection of pituitary antibodies by immunofluorescence: approach and results in patients with pituitary diseases." J Clin Endocrinol Metab. 2014 May;99(5):1758-66. doi: 10.1210/jc.2014-1049. Epub 2014 Feb 25.
  5. Caturegli P, De Remigis A, Rose NR. "Hashimoto thyroiditis: clinical and diagnostic criteria." Autoimmun Rev. 2014 Apr-May;13(4-5):391-7. doi: 10.1016/j.autrev.2014.01.007. Epub 2014 Jan 13. Review.

Lupi I, Raffaelli V, Di Cianni G, Caturegli P, Manetti L, Ciccarone AM, Bogazzi F, Mariotti S, Del Prato S, Martino E. Pituitary autoimmunity in patients with diabetes mellitus and other endocrine disorders. J Endocrinol Invest. 2013 Feb;36(2):127-31.

Bose V, Caturegli P, Conrad J, Omran W, Boor S, Giese A, Gutenberg A. Use of a clinicoradiological score to determine the presurgical diagnosis of autoimmune hypophysitis in a teenage girl. J Neurosurg Pediatr. 2013 Mar;11(3):335-9.

Caturegli P, De Remigis A, Chuang K, Dembele M, Iwama A, Iwama S. Hashimoto's thyroiditis: celebrating the centennial through the lens of the Johns Hopkins hospital surgical pathology records. Thyroid. 2013 Feb;23(2):142-50

Maleszewski JJ, Murray DL, Dispenzieri A, Grogan M, Pereira NL, Jenkins SM, Judge DP, Caturegli P, Vrana JA, Theis JD, Dogan A, Halushka MK. Relationship between monoclonal gammopathy and cardiac amyloid type. Cardiovasc Pathol. 2012 Oct 24.

Caturegli P, De Remigis A, Ferlito M, Landek-Salgado MA, Iwama S, Tzou SC, Ladenson PW. Anatabine ameliorates experimental autoimmune thyroiditis. Endocrinology. 2012 Sep;153(9):4580-7.

Iwama S, De Remigis A, Bishop JA, Kimura HJ, Caturegli P. Hürthle cells predict hypothyroidism in interferon-? transgenic mice of different genetic backgrounds.Endocrinology. 2012 Aug;153(8):4059-66.

Academic Affiliations & Courses

Graduate Program Affiliation

Cellular and Molecular Medicine

Pathobiology

Molecular Microbiology and Immunology

Pathobiology

Courses and Syllabi

  • Autoimmune Diseases of the Endocrine Glands (260.633.01)
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