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Photo of Dr. Patrizio Caturegli, MD MPH

Patrizio Caturegli, MD MPH

Director, Hypophysitis Center
Associate Professor of Pathology
Male
Appointment Phone

443-287-8911

Main Location

The Johns Hopkins Hospital

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Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

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Call +1-410-502-0773 (7a.m. to 6p.m., EST, Mon-Fri)

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Titles

  • Director, Hypophysitis Center
  • Associate Professor of Pathology

Centers & Institutes

  • Autoimmune Disease Research Center
  • Hypophysitis Center

Expertise

Pathology

Research Interests

Autoimmune disease; Thyroid disease; Pituitary disease; Endocrinology; Myocarditis; Thyroiditis; Hypophysitis; Sjogren's syndrome; Congenital complete heart block; Hurthle cell lesions; Autoantibodies; Thyroglobulin; Thyroid peroxidase (TPO)

Biography

Dr. Patrizio P. Caturegli is an associate professor of pathology at the Johns Hopkins University School of Medicine. An immunopathologist, Dr. Caturegli is the director of the Johns Hopkins Hypophysitis Center and serves on the faculty of the Autoimmune Disease Research Center.

His clinical and research focus is autoimmune diseases of the endocrine glands. These include myocarditis, thyroiditis, hypophysitis, Sjogren''s syndrome, and complete congenital heart blockage.

Dr. Caturegli earned his medical degree from Italy’s Faculty of Medicine E Chirurgua University of Pisa. He completed a residency in endocrinology at the University of Pisa and a residency in pathology at Johns Hopkins. He performed a fellowship in public health at Johns Hopkins where he also earned a M.P.H. from Hopkins’ Bloomberg School of Public Health. He joined the Johns Hopkins faculty in 1999.

He is American Board of Pathology-certified in clinical pathology and has published more than 100 journal articles.

Languages

  • English
  • Italian
Additional Resources +
  • Education +

    Training

    • Johns Hopkins Bloomberg School of Public Health (Baltimore MD) (2004)
    • Faculty Of Medicine E Chirurgua University Of Pisa (Pisa ) (1987)

    Residencies

    • Johns Hopkins University School of Medicine / Pathology (Baltimore MD) (1998)
    • University of Pisa / Endocrinology (Pisa ) (1993)

    Fellowships

    • Johns Hopkins University Bloomberg School of Public Health (Baltimore MD) (1996)

    Certifications

    • American Board of Pathology / Clinical Pathology (1999)
  • Research & Publications +

    Research Summary

    Dr. Caturegli’s research focuses on autoimmune diseases of the endocrine glands, with particular focus on those affecting the thyroid and pituitary.

    His team has shown that transgenic mice expressing interferon-gamma specifically in the thyroid gland develop a metaplastic transformation of the thyrocyte resembling the human Hürthle cell, a cell characteristically found in Hashimoto thyroiditis.

    This transformation depends upon the overexpression of the immunoproteasome—specifically, its LMP2 subunit.

    Our team is now evaluating the efficacy of new immunoproteasome inhibitors for the treatment of Hürthle cell lesions.

    In the pituitary model, studies have led to the development of a mouse model of autoimmune hypophysitis, a model the lab is using to explore two aspects relevant to human health: 

    • The identification of the pituitary antigens recognized by the immune system in patients with hypophysitis 
    • The recently reported association between hypophysitis and treatments used in patients with cancer to block T cell inhibitory signals, such as CTLA-4

    Selected Publications

    1. De Remigis A, de Gruijl TD, Uram JN, Tzou SC, Iwama S, Talor MV, Armstrong TD, Santegoets SJ, Slovin SF, Zheng L, Laheru DA, Jaffee EM, Gerritsen WR, van den Eertwegh AJ, Le DT, Caturegli P. “Development of thyroglobulin antibodies after GVAX immunotherapy is associated with prolonged survival.” Int J Cancer. 2014 May 15. doi: 10.1002/ijc.28973. [Epub ahead of print]
    2. McLeod DS, Caturegli P, Cooper DS, Matos PG, Hutfless S. “Variation in rates of autoimmune thyroid disease by race/ethnicity in US military personnel.” JAMA. 2014 Apr 16;311(15):1563-5. doi: 10.1001/jama.2013.285606. No abstract available.
    3. Iwama S, De Remigis A, Callahan MK, Slovin SF, Wolchok JD, Caturegli P. “Pituitary expression of CTLA-4 mediates hypophysitis secondary to administration of CTLA-4 blocking antibody.” Sci Transl Med. 2014 Apr 2;6(230):230ra45. doi: 10.1126/scitranslmed.3008002.
    4. Ricciuti A, De Remigis A, Landek-Salgado MA, De Vincentiis L, Guaraldi F, Lupi I, Iwama S, Wand GS, Salvatori R, Caturegli P. “Detection of pituitary antibodies by immunofluorescence: approach and results in patients with pituitary diseases.” J Clin Endocrinol Metab. 2014 May;99(5):1758-66. doi: 10.1210/jc.2014-1049. Epub 2014 Feb 25.
    5. Caturegli P, De Remigis A, Rose NR. “Hashimoto thyroiditis: clinical and diagnostic criteria.” Autoimmun Rev. 2014 Apr-May;13(4-5):391-7. doi: 10.1016/j.autrev.2014.01.007. Epub 2014 Jan 13. Review.
  • Academic Affiliations & Courses +

    Graduate Program Affiliation

    Cellular and Molecular Medicine

    Pathobiology

    Molecular Microbiology and Immunology

    Pathobiology

    Courses and Syllabi

    260.633.01 Autoimmune Diseases of the Endocrine Glands

  • Activities & Honors +
  • Videos & Media +
  • Events +
  • Contact & Locations +

    Locations

    The Johns Hopkins Hospital
    600 N. Wolfe Street
    Hospital Main Entrance - Sheikh Zayed Tower
    Baltimore, MD 21287
    Phone: 443-287-8911
    Appointment Phone: 443-287-8911
    Location Map

    Department/Division

    • Pathology

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