Dr. Caturegli’s research focuses on autoimmune diseases of the endocrine glands, with particular focus on those affecting the thyroid and pituitary.
His team has shown that transgenic mice expressing interferon-gamma specifically in the thyroid gland develop a metaplastic transformation of the thyrocyte resembling the human Hürthle cell, a cell characteristically found in Hashimoto thyroiditis.
This transformation depends upon the overexpression of the immunoproteasome—specifically, its LMP2 subunit.
Our team is now evaluating the efficacy of new immunoproteasome inhibitors for the treatment of Hürthle cell lesions.
In the pituitary model, studies have led to the development of a mouse model of autoimmune hypophysitis, a model the lab is using to explore two aspects relevant to human health:
- The identification of the pituitary antigens recognized by the immune system in patients with hypophysitis
- The recently reported association between hypophysitis and treatments used in patients with cancer to block T cell inhibitory signals, such as CTLA-4
- De Remigis A, de Gruijl TD, Uram JN, Tzou SC, Iwama S, Talor MV, Armstrong TD, Santegoets SJ, Slovin SF, Zheng L, Laheru DA, Jaffee EM, Gerritsen WR, van den Eertwegh AJ, Le DT, Caturegli P. “Development of thyroglobulin antibodies after GVAX immunotherapy is associated with prolonged survival.” Int J Cancer. 2014 May 15. doi: 10.1002/ijc.28973. [Epub ahead of print]
- McLeod DS, Caturegli P, Cooper DS, Matos PG, Hutfless S. “Variation in rates of autoimmune thyroid disease by race/ethnicity in US military personnel.” JAMA. 2014 Apr 16;311(15):1563-5. doi: 10.1001/jama.2013.285606. No abstract available.
- Iwama S, De Remigis A, Callahan MK, Slovin SF, Wolchok JD, Caturegli P. “Pituitary expression of CTLA-4 mediates hypophysitis secondary to administration of CTLA-4 blocking antibody.” Sci Transl Med. 2014 Apr 2;6(230):230ra45. doi: 10.1126/scitranslmed.3008002.
- Ricciuti A, De Remigis A, Landek-Salgado MA, De Vincentiis L, Guaraldi F, Lupi I, Iwama S, Wand GS, Salvatori R, Caturegli P. “Detection of pituitary antibodies by immunofluorescence: approach and results in patients with pituitary diseases.” J Clin Endocrinol Metab. 2014 May;99(5):1758-66. doi: 10.1210/jc.2014-1049. Epub 2014 Feb 25.
- Caturegli P, De Remigis A, Rose NR. “Hashimoto thyroiditis: clinical and diagnostic criteria.” Autoimmun Rev. 2014 Apr-May;13(4-5):391-7. doi: 10.1016/j.autrev.2014.01.007. Epub 2014 Jan 13. Review.