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Argye Hillis, MD

Argye Elizabeth Hillis, MD
Director, Cerebrovascular Division of Neurology
Professor of Neurology

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  • Director, Cerebrovascular Division of Neurology
  • Executive Vice Chair, Department of Neurology
  • Professor of Neurology
  • Professor of Physical Medicine and Rehabilitation

Centers & Institutes

  • Cerebrovascular Center


Aphasia, Apraxia, Cortical Visual and Perceptual Impairments, Corticobasal Degeneration, Dementia, Neurology, Speech and Language Impairments, Stroke

Research Interests

Dr. Hillis's current research combines longitudinal task-related and task-free functional imaging and structural imaging from the acute stage of stroke through the first year of recovery, with detailed cognitive and language assessments to improve our understanding how language and other cognitive functions recover after stroke. Her other avenue of research involves novel treatment studies and longitudinal imaging and language studies of Primary Progressive Aphasia. She has published extensively on these topics in journals and textbooks.


Dr. Argye Hillis is a professor of Neurology, with joint faculty appointments in Physical Medicine and Rehabilitation and in Cognitive Science.

Prior to medical training and neurology residency, Dr. Hillis worked as a speech-language pathologist, and conducted clinical research focusing on understanding and treating aphasia and hemispatial neglect. She has brought these areas of experience to impact on her clinical research in neurology, which involves cognitive and neuroimaging studies of aphasia and hemispatial neglect due to acute stroke and focal dementias. She has published extensively on these topics in journals and textbooks.

Dr. Hillis is Co-Editor-in Chief of Behavioural Neurology and has served as Associate editor of Brain, Annals of Neurology, Aphasiology, American Journal of Speech-Language Pathology, Neurocase, Cognitive Neuropsychology, and Language and Cognitive Processes and serves on the editorial board of Brain and Language.

Dr. Hillis serves as the Executive Vice Chair of the Department of Neurology, Director of the Neurology Residency Program, and the Co-Director of the Cerebrovascular Division of Neurology at Johns Hopkins.


  • English


World Federation of Neurology- Research Group on Aphasia and Cognitive Disorders; Chair, 2004-2008.

F1000 Medicine (Faculty 1000 Medicine) Evaluation Board

American Neurological Association; Scientific Program Committee (2004-2006)

American Heart Association Stroke Council; Fellow;Abstract Reviewer for the International Stroke Conference (2003-2007); Scientific Session Chair, 2005, 2006

Academy of Aphasia,

Clinical Aphasiology Conference; Program committee 1985, 1992; Program Chair 2003; Conference Chair 2004; Steering Committee (2003-present)

American Academy of Neurology (and Section on Behavioral Neurology)

Society for Neuroscience

Additional Resources

Additional Resources +
  • Education +


    • Johns Hopkins University School of Medicine (Baltimore MD ) (1995)


    • Johns Hopkins University School of Medicine / Neurology (Baltimore MD ) (1999)


    • Neurology, American Board of Psychiatry & Neurology (2011)
  • Research & Publications +

    Research Summary

    Following a stroke, an individual may experience speech, language, cognitive, or emotional problems. Dr. Hillis’ current research aims to improve the understanding of how language and other cognitive functions are represented and carried out in the brain, how they recover after injury, and how understanding these processes can contribute to evaluation and treatment of stroke and dementia. Specifically, current research studies include the following:

    Selected Publications View all on PubMed

    SELECTED PUBLICATIONS (from >150 total)

    Hillis, A.E. (1989). Efficacy and generalization of treatment for aphasic naming errors. Archives of Physical Medicine and Rehabilitation, 70, 632-636.

    Caramazza, A. & Hillis, A.E. (1991). Lexical organization of nouns and verbs in the brain. Nature, 349,788-90.

    Hillis, A.E. & Caramazza, A. (1991). Category-specific naming and comprehension impairment: A double dissociation. Brain, 114, 2081-2094.

    Hillis, A.E. & Caramazza, A. (1995). Cognitive and neural mechanisms underlying visual and semantic processing. Journal of Cognitive Neuroscience, 7, 457-478.

    Hillis, A.E. & Caramazza, A. (1995). The representation of grammatical categories of words in the brain. Journal of Cognitive Neuroscience, 7, 396-407.

    Hillis, A.E., Boatman, D., Hart, J. & Gordon, B. (1999). Making sense out of jargon: a neurolinguistic and computational account of jargon aphasia. Neurology, 53, 1813-1824.

    Hillis, A.E., Wityk, R.J., Tuffiash, E., Beauchamp, N.J., Jacobs, M.A., Barker, P.B., Selnes, O.A. (2001). Hypoperfusion of Wernickes area predicts severity of semantic deficit in acute stroke. Annals of Neurology, 50, 561-566.

    Hillis, A.E., Wityk, R.J., Barker, P.B., Beauchamp, N.J., Gailloud, P., Murphy, K., Cooper, O., Metter, E.J. (2002). Subcortical aphasia and neglect in acute stroke: the role of cortical hypoperfusion, Brain,125, 1094-1104.

    Hillis, A.E., Tuffiash, E. & Caramazza, A. (2002). Modality specific deterioration in oral naming of verbs. Journal of Cognitive Neuroscience, 14, 1099-1108.

    Hillis, A.E., Wityk, R., Barker, P.B., Caramazza, A. (2003). Neural regions essential for writing verbs. Nature Neuroscience, 6, 19-20.

    Hillis, A.E., Oh, S., Ken, L. (2004). Deterioration of naming nouns versus verbs in primary progressive aphasia. Annals of Neurology, 55, 268-275.

    Hillis, A.E., Work, M., Breese, E.L., Barker, P.B., Jacobs, M.A. & Maurer, K. (2004). Re-examining the brain regions crucial for orchestrating speech articulation. Brain, 127, 1479-1487.

    Hillis, A.E., Newhart, M., Heidler, J., Barker, P.B., Herskovits, E., and Degaonkar, M. (2005). The roles of the visual word form area in reading. NeuroImage, 24, 548-559.

    Reineck, L., Agarwal, S. & Hillis, A.E. (2005). The diffusion-clinical mismatch predicts early language recovery in acute stroke. Neurology, 64, 828-833.

    Hillis, A.E., Newhart, M., Heidler, J., Barker, P.B., Degaonkar, M. (2005). Anatomy of spatial attention: insights from perfusion imaging and hemispatial neglect in acute stroke. Journal of Neuroscience, 25, 3161-7.

    Charles, R. & Hillis, A.E. (2005). Posterior Cortical Atrophy: clinical presentation and cognitive deficits compared to Alzheimers Disease. Behavioural Neurology, 16, 15-23.

    Hillis, A.E., Heidler-Gary, J., Newhart, M., Chang, S., Ken, L. & Bak, T. (2006). Naming and comprehension in primary progressive aphasia: the influence of grammatical word class. Aphasiology, 20, 246-256.

    Newhart, M., Ken, L., Kleinman, J.T., Heidler-Gary, J., & Hillis, A.E. (2007). Neural networks essential for naming and word comprehension. Cognitive and Behavioral Neurology, 20, 25-30.

    DeLeon, J., Gottesman, R.F., Kleinman, J.T., Newhart, M., Davis, C., Lee, A., Hillis, A.E. (2007) Neural regions essential for distinct cognitive processes underlying picture naming. Brain, 130, 1408-22.

    Heidler-Gary, J. & Hillis, A.E. (2007). Distinctions between the dementia in Amyotrophic Lateral Sclerosis with Frontotemporal Dementia and the dementia of Alzheimer''s Disease. Amyotrophic Lateral Sclerosis.

    Philipose, L.E., Gottesman, R.F., Newhart, M.; Kleinman, J.T.; Herskovits, E.H.; Pawlak, M.A., Marsh, E.B.; Davis, C.; Heidler-Gary, J.; Hillis, A.E. (2008). Neural regions essential for reading and spelling of words and pseudowords. Annals of Neurology. 481-492.

    Cloutman, L., Gottesman, R., Chaudhry, P., Davis, C., Kleinman, J.T., Pawlak, M., Herskovits, E.H., Kannan, V., Lee, A., Newhart, M., Heidler-Gary, J., Hillis, A.E. (2008)Where (in the brain) do semantic errors come from? Cortex. [Epub ahead of print]

    Medina, J., Kannan, V., Pawlak, M., Kleinman, J.T., Newhart, M., Davis, C., Heidler-Gary J.E., Herskovits,
    E.H., Hillis, A.E. (2008) Neural substrates of visuospatial processing in distinct reference frames: evidence from unilateral spatial neglect. Journal of Cognitive Neuroscience. [Epub ahead of print].

    Cloutman, L., Gingis, L., Newhart, M., Davis, C., Heidler-Gary, J., Crinion, J., Hillis, A.E. (in press). A neural
    network critical for spelling. Annals of Neurology.
  • Academic Affiliations & Courses +
  • Activities & Honors +


    Alpha Omega Alpha; Phi Beta Kappa; Intern of the Year; National Stroke Association Research Fellow;

    Fellow of the American Heart Association/ American Stroke Association

    Derek Denny-Brown Neurological Scholar Award (from the American Neurological Association)

    Norman Geschwind Award in Behavioral Neurology (from the American Academy of Neurology)

  • Videos & Media +

    Recent News Articles & Media Coverage

    Dealing with the emotional aspects of stroke rehab, Philadelphia Inquirer (04/13/2014)

    For our bodies we have gyms, and for our minds we have...brain fitness apps, ComputerWorld (01/13/2014)

  • Events +
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    • Neurology - Cerebrovascular

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