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Photo of Dr. Nicholas Maragakis

Nicholas John Maragakis, MD

Co-director, Michael S. and Karen G. Ansari ALS Center for Cell Therapy and Regeneration Research
Professor of Neurology

See Research on Pubmed | See Research on Google Scholar

Male
Appointment Phone

410-614-9874

Main Location

The Johns Hopkins Hospital

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Out-of-State & International Patients +
Out of State Patients

Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

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International Patients

Call +1-410-502-0773 (7a.m. to 6p.m., EST, Mon-Fri)

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Titles

  • Co-director, Michael S. and Karen G. Ansari ALS Center for Cell Therapy and Regeneration Research
  • Professor of Neurology

Centers & Institutes

  • ALS Center for Cell Therapy and Regeneration Research
  • ALS Clinic
  • Institute for Cell Engineering

Expertise

Amyotrophic Lateral Sclerosis, Lou Gehrig's Disease, Neurology

Biography

Dr. Maragakis treats patients with a variety of neuromuscular disorders. His clinical practice is particularly notable for its attention to patients with motor neuron diseases, such as Amyotrophic Lateral Sclerosis (ALS). This expertise is coordinated with the ALS clinic at Johns Hopkins, a multidisciplinary clinic with expertise in treating ALS patients and providing support to their caregivers. As an extension of Dr. Maragakis clinic, he is an investigator in clinical trials for ALS patients.

Dr. Maragakis has interests in both the basic science of understanding neurologic disease as well as clinical investigations for treating neurologic disorders. His laboratory studies the role of astrocytes (the supporting cells of the brain) in causing and propagating neurological diseases, such as ALS. His interests also include the use and transplantation of astrocyte stem cells into animal models of diseases to establish their potential to treat patients with neurologic disease. His clinical research interests have included the treatment of patients with ALS using new drug therapies. Studies are also planned to evaluate potentially new approaches in ALS therapy.

Languages

  • English

Additional Resources

Additional Resources +
  • Education +

    Training

    • The University of Utah (Salt Lake City UT) (1994)

    Residencies

    • Johns Hopkins University School of Medicine / Neurology (Baltimore MD) (1998)

    Fellowships

    • Johns Hopkins University School of Medicine (Baltimore MD) (2000)
    • Johns Hopkins University School of Medicine / Neuromuscular Medicine (Baltimore MD) (1999)

    Certifications

    • American Board of Psychiatry & Neurology / Neurology (2010)
  • Research & Publications +

    Selected Publications View all on PubMed

    1. Haidet-Phillips AM, Roybon L, Gross SK, Tuteja A, Donnelly CJ, Richard JP, Ko M, Sherman A, Eggan K, Henderson CE, Maragakis NJ. Gene profiling of human induced pluripotent stem cell-derived astrocyte progenitors following spinal cord engraftment. Stem Cells Transl Med. 2014 May;3(5):575-85. doi: 10.5966/sctm.2013-0153. Epub 2014 Mar 6. PMID: 24604284 
    2. Haeusler AR, Donnelly CJ, Periz G, Simko EA, Shaw PG, Kim MS, Maragakis NJ, Troncoso JC, Pandey A, Sattler R, Rothstein JD, Wang J. C9orf72 nucleotide repeat structures initiate molecular cascades of disease. Nature. 2014 Mar 13;507(7491):195-200. doi: 10.1038/nature13124. Epub 2014 Mar 5. PMID: 24598541
    3. Rutkove SB, Caress JB, Cartwright MS, Burns TM, Warder J, David WS, Goyal N, Maragakis NJ, Benatar M, Sharma KR, Narayanaswami P, Raynor EM, Watson ML, Shefner JM. Electrical impedance myography correlates with standard measures of ALS severity. Muscle Nerve. 2014 Mar;49(3):441-3. doi: 10.1002/mus.24128. Epub 2013 Dec 19. PMID: 24273034 
    4. Haidet-Phillips AM, Gross SK, Williams T, Tuteja A, Sherman A, Ko M, Jeong YH, Wong PC, Maragakis NJ. Altered astrocytic expression of TDP-43 does not influence motor neuron survival. Exp Neurol. 2013 Dec;250:250-9. doi: 10.1016/j.expneurol.2013.10.004. Epub 2013 Oct 9. PMID: 24120466
    5. Roth NM, Saidha S, Zimmermann H, Brandt AU, Oberwahrenbrock T, Maragakis NJ, Tumani H, Ludolph AC, Meyer T, Calabresi PA, Paul F. Optical coherence tomography does not support optic nerve involvement in amyotrophic lateral sclerosis. Eur J Neurol. 2013 Aug;20(8):1170-6. doi: 10.1111/ene.12146. Epub 2013 Apr 14. PMID: 23582075

    Lab

    The Maragakis lab's main focus is in understanding disease mechanisms and targeting cell therapeutics for Amyotrophic Lateral Sclerosis (ALS). In collaboration with Johns Hopkins neuroscientists, his laboratory helped create stem cell lines from ALS patients using induced pluripotent stem cell (iPSC) methodologies. These cells will allow for the development of human cell lines which can be used for both the basic understanding of ALS astrocyte and motor neuron biology, as well as eventually identifying ALS therapeutics. Researchers in the Maragakis lab also focus on the potential therapeutic role of astrocyte replacement in ALS using glial stem cells. By transplanting glial stem cells into ALS animal models, the researchers in the Maragakis lab found that the stem cells can engraft, migrate and differentiate into astrocytes, and subsequently provide neuroprotection to vulnerable motor neuron pools. The team uses stem cell transplantation biology to understand the influences of mutant SOD1 astrocytes on normal, healthy motor neurons. A significant laboratory effort is underway to translate these discoveries into therapies for patients with ALS.

  • Academic Affiliations & Courses +
  • Activities & Honors +
  • Videos & Media +

    Videos

    Stem Cell Implications for ALS (Amyotrophic Lateral Sclerosis)

  • Events +
  • Contact & Locations +

    Locations

    The Johns Hopkins Hospital
    600 N. Wolfe Street
    Hospital Main Entrance - Sheikh Zayed Tower
    Baltimore, MD 21287
    Appointment Phone: 410-614-9874
    Location Map
    Johns Hopkins Outpatient Center
    601 N. Caroline Street
    Baltimore, MD 21287
    Appointment Phone: 410-614-9874
    Location Map

    Department/Division

    • Neurology - Neuromuscular

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