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Lili Ayala Barouch, M.D.

Photo of Dr. Lili Ayala Barouch, M.D.

Associate Professor of Medicine

Associate Professor of Medicine


Expertise: Cardiac Sarcoidosis, Cardiomyopathy, Cardiovascular Disease, Cardiovascular Disease in Women, Cardiovascular Diseases, Chemotherapy-Induced Cardiomyopathy, Congestive Heart Failure (CHF), Heart Disease, Heart Failure, Heart Transplant, Hypertrophic Cardiomyopathy, Ischemic Heart Disease, Mechanical Circulatory Support, Peripartum Cardiomyopathy more

Research Interests: Obesity and congestive heart failure; Leptin signaling and cardiac hypertrophy; Beta 3 adrenergic signaling and cardiac remodeling; Cardioprotective effect of beta-3 adrenergic receptor signaling more

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Johns Hopkins Cardiology - Columbia
Appointment Phone: 410-964-5303

5450 Knoll North Drive
Columbia, MD 21045 map
Phone: 410-964-5303
Fax: 410-964-5329



  • Associate Professor of Medicine
  • Director, Columbia Heart Failure Clinic
  • Associate Professor of Medicine

Departments / Divisions



  • MD, Johns Hopkins University School of Medicine (1996)


  • Johns Hopkins University School of Medicine / Internal Medicine (1999)


  • Johns Hopkins University School of Medicine / Cardiology (2003)

Board Certifications

  • American Board of Internal Medicine / Advanced Heart Failure and Transplant Cardiology (2010)
  • American Board of Internal Medicine / Cardiovascular Disease (2003)

Research & Publications


Dr. Barouch’s laboratory is focused on defining the peripheral cardiovascular effects of the adipocytokine leptin, which is a key to the understanding of obesity-related cardiovascular disease. Interestingly, many of the hormonal abnormalities seen in obesity are mimicked in heart failure. The research program will enhance the understanding of metabolic signaling in the heart, including the effects of leptin, exercise, sex hormones, and downstream signaling pathways on metabolism and cardiovascular function. The lab also is working to determine the precise role of the “metabolic” beta-3 adrenergic receptor (ß3AR) in the heart and define the extent of its protective effect in obesity and in heart failure, including its role in maintaining nitric oxide synthase (NOS) coupling. Ultimately, this work will enable the exploration of a possible therapeutic role of ß3AR agonists and re-coupling of NOS in preventing adverse ventricular remodeling in obesity and in heart failure.

Selected Publications

View all on Pubmed

Barouch LA, Harrison RW, Skaf MW, Rosas GO, Cappola TP, Kobeissi ZA, Hobai IA, Lemmon CA, Burnett AL, O'Rourke B, Rodriguez ER, Huang PL, Lima JAC, Berkowitz DE, Hare JM. Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms. Nature. 2002; 416:337-339

Barouch LA, Gao D, Chen L, Miller KL, Xu W, Phan AC, Kittleson MK, Minhas KM, Berkowitz DE, Wei C, Hare JM. Cardiac myocyte apoptosis is associated with increased DNA damage and decreased survival in murine models of obesity. Circulation Research. 2006; 98(1):119-24

Yang R, Sikka G, Larson J, Watts VL, Niu X, Ellis CL, Miller KL, Camara A, Reinke C, Savransky V, Polotsky VY, O'Donnell CP, Berkowitz DE, Barouch LA. Restoring leptin signaling reduces hyperlipidemia and improves vascular stiffness induced by chronic intermittent hypoxia. American J Physiol Heart Circ Physiol. 2011; 300(4):H1467-76

Niu X, Watts VL, Cingolani OH, Sivakumaran V, Leyton-Mange JS, CL, Miller KL, Vandegaer K, Bedja D, Gabrielson KL, Paolocci‎ N, Kass DA, Barouch LA. Cardioprotective Effect of Beta-3 Adrenergic Receptor Agonism: Role of Neuronal Nitric Oxide Synthase. JACC. 2012; 59(22):1979-87

Watts VL, Sepulveda FM, Cingolani OH, Ho AS, Niu X, Kim R, Miller KL, Vandegaer K, Bedja D, Gabrielson KL, Rameau G, O'Rourke B, Kass DA, Barouch LA. Anti-hypertrophic and anti-oxidant effect of beta3-adrenergic stimulation in myocytes requires differential neuronal NOS phosphorylation. J Mol Cell Cardiol. 2013; 62:8-17

Activities & Honors


  • Trainee Abstract Award, American Heart Association Council on Basic Cardiovascular Sciences, 2001
  • 1st Place, Fellow Division, Mid-Atlantic Cardiovascular Research Competition, 2001
  • Bristol-Myers-Squibb Travel Award, American College of Cardiology Scientific Session, 2002
  • Finalist, Fellow Basic Science Poster Award, Department of Medicine Research Retreat, Johns Hopkins Medical Institutions, 2002
  • Trainee Best Poster Award, American Society for Clinical Investigation and American Academy of Physicians Joint Meeting, 2003
  • Fellow Basic Science Poster Award, and Facilitated Poster Session on Obesity/Metabolism, Department of Medicine Research Retreat, Johns Hopkins Medical Institutions, 2003
  • Finalist, Poster Competition in Basic Sciences, American Heart Association Scientific Sessions, 2004
  • Sponsored Young Investigator, GlaxoSmithKline Research and Education Foundation for Cardiovascular Disease Symposium: New Frontiers in Genomics and Cardiovascular Disease, 2005
  • Junior Faculty Basic Science Poster Award, Department of Medicine Research Retreat, Johns Hopkins Medical Institutions, 2005
  • Finalist, Northwestern Cardiovascular Forum Young Investigators Award, Junior Faculty Division, 2008


  • American College of Cardiology, 1999
  • American College of Cardiology Women in Cardiology Section, 2004
  • American Heart Association, 1999
  • American Heart Association Council on Basic Cardiovascular Sciences, 2001

Videos & Media

Recent News Articles and Media Coverage

Heart Disease Doesn't Discriminate (news article)

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