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Ned Charlton Sacktor, MD

Professor of Neurology

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Johns Hopkins Bayview Medical Center

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  • Professor of Neurology

Centers & Institutes

  • Memory and Alzheimer's Disease Treatment Center


Behavioral Disorders in Dementia, Dementia, Neurology

Research Interests

HIV associated neurocognitive disorders


Dr. Ned Sacktor focuses on general neurology with a special interest in dementia and behavioral neurology.

Dr. Ned Sacktor received his medical degree from the University of Pennsylvania School of Medicine. He then completed a residency in neurology at the Neurological Institute of New York, Columbia Presbyterian Hospital. He went on to complete a behavioral neurology fellowship at the same institution.


  • English


American Academy of Neurology
American Neurological Association

Clinical Trial Keywords

  • HIV dementia

Additional Resources

Additional Resources +
  • Education +


    • Hospital of the University of Pennsylvania (Philadelphia PA ) (1988)


    • Columbia CollegeColumbia University / Neurology (New York NY ) (1992)


    • Neurological Institute of New York (New York NY ) (1994)


    • Neurology, American Board of Psychiatry & Neurology (1993)
  • Research & Publications +

    Research Summary

    Dr. Sacktor's research focuses primarily on the cognitive manifestations of HIV infection. These investigations include clinical, epidemiological and neuroimaging studies. He also focuses on trials of therapeutic agents for the treatment of HIV-associated dementia.

    Selected Publications

    Selected Peer-reviewed Publications (in chronological order)
    Sacktor, N., Bacellar, H., Hoover, D.R., Nance-Sproson, T.E., Selnes, O.A., Miller, E.N., Dal Pan, G.J., Kleeberger, C., Brown, A., Saah, A., McArthur, J.C. Psychomotor slowing in HIV infection: a predictor of dementia, AIDS, and death. J Neurovirology 1996:2;404-410.
    Sacktor, N. (Corresponding author). The Dana Consortium on the Therapy for HIV Dementia and Related Cognitive Disorders. A randomized, double-blind, placebo-controlled trial of deprenyl and thioctic acid in HIV associated cognitive impairment. Neurology 1998;50:645-651.
    Sacktor, N.C., Lyles, R.H., Skolasky, R.L., Anderson, D.E., McArthur, J.C., McFarlane, G., Selnes, O.A., Becker, J.T., Cohen, B., Wesch, J., Miller, E.N. Combination antiretroviral therapy improves psychomotor speed performance In HIV+ homosexual men. Neurology 1999;52:1640-1647.
    Sacktor, N., Schifitto, G., McDermott, M.P., Marder, K., McArthur, J.C., Kieburtz, K. Transdermal selegiline in HIV-associated cognitive impairment: a pilot, placebo-controlled study. Neurology 2000;54:233-235.
    Sacktor, N., Lyles, R., Skolasky R., Kleeberger, C., Selnes, O.A., Miller, E.N., Becker, J.T., Cohen, B., McArthur, J.C., and the Multicenter AIDS Cohort Study. HIV-associated neurological disease incidence changes: Multicenter AIDS Cohort Study, 1990-1998. Neurology 2001;56:257-260.
    Sacktor, N., McDermott, M.P., Marder, K., Schifitto, G., Selnes, O.A., McArthur, J.C., Stern, Y., Albert, S., Palumbo,D.,Kieburtz, K., Marcaida, J., Cohen, B., Epstein, L. HIV associated cognitive impairment before and after the advent of combination therapy. J NeuroVirology 2002;8:136-142.
    Sacktor, N., Haughey, N., Cutler, R., Tamara, A., Turchan, J., Pardo, C., Vargas, D., Nath, A. Novel markers of oxidative stress in actively progressive HIV dementia. J Neuroimmunol 2004;157:176-184.
    Sacktor, N., Wong, M., Nakasujja, N., Skolasky, R., Selnes, O., Musisi, S., Robertson, K., McArthur, J., Ronald, A., Katabira, E. The International HIV Dementia Scale: a new rapid screening test for HIV dementia. AIDS 2005 19;1367-1374.
    Sacktor, N., Skolasky, R., Selnes, O., Watters, M., Poff, P., Shiramizu, B., Shikuma, C., Valcour, V. Neuropsychological test profile differences between young and old HIV+ individuals. J Neurovirology 2007;13:203-209.
    Sacktor, N, Nakasujja, N., Robertson, K., Clifford, D. HIV-associated cognitive impairment in Sub-Saharan Africa: the potential impact of clade diversity. Nature Clinical Practice Neurology 2007 Aug;3(8) 436-443.
    Sacktor, N, Nakasujja, N., Skolasky, R., Robertson, K., Musisi, S., Ronald, A., Katabira, E., Clifford, D. B. Benefits and risks of stavudine therapy for HIV associated neurological complications in Uganda. Neurology 2009;72:165-170.
    Sacktor, N., Nakasujja, N., Skolasky, R., Rezapour, M., Robertson, K., Musisi, S., Katabira, E., Ronald, A., Clifford, D., Laeyendecker, O., Quinn, T. HIV subtype D is associated with dementia compared to subtype A in immunosuppressed individuals at risk for cognitive impairment in Kampala, Uganda. Clin Inf Dis 2009;49:780-786.
    Mohamed, M.A., Barker, P.B., Skolasky, R.L., Moxley, R.T., Pomper, M.G., Sacktor, N.C. Decreased brain Glx levels in HIV dementia: a 3 tesla MR spectroscopy study. MRI 2010;1251-1257.
    Sacktor, N., Skolasky, R.L., Cox, C., Selnes, O., Becker, J.T., Cohen, B., Martin, E., Miller, E., for the Multicenter AIDS Cohort Study (MACS). Longitudinal psychomotor speed performance in HIV+ individuals: impact of age and serostatus. J NeuroVirology 2010; 335-341.
    Gandhi,N; Moxley R; Creighton,J.; Vornbrock Roosa,H; Selnes,O.; McArthur J.C.; Sacktor N. Comparison of scales to evaluate the progression of HIV-associated neurocognitive disorder. HIV Therapy 2010 4: 3:371-379.
    Sacktor, N., Miyahara, S., Deng, L., Evans, S., Schifitto, G., Cohen, B.A., Paul, R., Robertson, K., Jarocki, B., Scarsi, K., Coombs, R.W., Zink, M.C., Nath, A., Smith, E., Ellis, R.J., Singer, E., Weihe, J., McCarthy, S., Hosey, L., Clifford, D.B., and the ACTG 5235 team. Minocycline treatment for HIV-associated cognitive impairment: results from a randomized trial. Neurology 2011 (in press).

  • Academic Affiliations & Courses +
  • Activities & Honors +


    1984 Summa Cum Laude, Phi Beta Kappa, Harvard College
    1997-1998 Maryland Neurological Society President
    2004-present Neurologic AIDS Research Consortium Leadership Committee Member
    2004-2005 Adult AIDS Clinical Trials Group Dementia Focus Group Chairman
    2006-2007 Adult AIDS Clinical Trials Group Neurology Subcommittee Chairman
    2009-present World Neurology Foundation Board of Directors, Member

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  • Contact & Locations +


    Johns Hopkins Bayview Medical Center
    4940 Eastern Avenue
    Lord Mason Drive, Building 301
    Room 2100
    Baltimore, MD 21224
    Phone: 410-550-1045
    Appointment Phone: 410-550-5624
    Fax: 410-550-0539
    Location Map
    The Johns Hopkins Hospital
    600 N. Wolfe Street
    Sheikh Zayed Tower
    Baltimore, MD 21287
    Appointment Phone: 410-955-9441
    Location Map


    • Neurology - Neuroimmunology

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