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Photo of Dr. Angelo DeMarzo

Angelo Michael DeMarzo, M.D., Ph.D.

Associate Director of Cancer Research Pathology, SKCCC
Professor of Pathology

Male

Appointment Phone

410-614-5686

Main Location

The Johns Hopkins Hospital

Out-of-State & International Patients +
Out of State Patients

Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

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International Patients

Call +1-410-502-7683 (7a.m. to 6p.m., EST, Mon-Fri)

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Titles

  • Associate Director of Cancer Research Pathology, SKCCC
  • Director, Tissue Microarray Core Facility
  • Professor of Pathology
  • Professor of Oncology
  • Professor of Urology

Centers & Institutes

Departments

  • Oncology - Prostate Cancer/GU
  • Pathology - Kidney-Urologic Pathology
  • Urology

Locations

The Johns Hopkins Hospital

Appointment Phone: 410-614-5686

600 N. Wolfe Street
Sheikh Zayed Tower
Baltimore, MD 21287 map

Expertise

Pathology, Prostate Cancer

Research Interests

Tissue microarrays; Biomarker development; Biospecimen banking; MYC, PTEN and prostate cancer; Prostate cancer and inflammation

Biography

Dr. Angelo De Marzo is a professor of pathology, oncology and urology at the Johns Hopkins School of Medicine. His areas of clinical expertise include pathology and prostate cancer. Dr. De Marzo serves as the associate director of Cancer Research Pathology at the Sidney Kimmel Comprehensive Cancer Center.

Dr. De Marzo founded the Tissue Microarray Core at Johns Hopkins, now known as the Oncology Tissue Services. He led it for a decade and now serves as an advisor to the core.

Dr. De Marzo's research interests include the molecular pathobiology of prostate cancer, biospecimen banking, biomarker development and tissue microarrays.

Dr. De Marzo received his B.A. in molecular, cellular and developmental biology and psychology from the University of Colorado at Boulder. He earned his M.D. and Ph.D. in experimental pathology from University of Colorado Health Sciences Center. He completed his residency in pathology at the Johns Hopkins School of Medicine and performed a fellowship at the Brady Urological Institute at Johns Hopkins. Dr. De Marzo joined the Johns Hopkins faculty in 1998.

Dr. De Marzo is Chief Medical Officer at Predictive Biosciences Inc., and serves on the editorial board of The Prostate and Cancer Prevention Research. He is the recipient of the 2004 Donald S. Coffey Prostate Cancer Foundation Physician/Scientist Award and is a member of various professional organizations, including the American Urological Association and the American Association for Cancer Research.

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    Additional Information

  • Education +

    Degrees

    • University of Colorado Health Sciences Center / MD (1994)

    Residencies

    • Johns Hopkins University School of Medicine / Pathology (1997)

    Fellowships

    • Johns Hopkins University School of Medicine (1998)

    Certifications

    • American Board of Pathology / Anatomic Pathology (1998)
  • Research & Publications +

    Research Summary

    Dr. De Marzo’s research focuses on prostate cancer, paying special attention to prevention. His research group has postulated that a common lesion often associated with inflammation—called proliferative inflammatory atrophy (PIA)—may represent a risk factor or precursor lesion to prostate cancer. This research has implications for prevention and chemoprevention of prostate cancer.

    Dr Marzo’s laboratory is also using genetically engineered mouse models and cell culture systems to study the role of the MYC oncogene in prostate cancer cell neoplastic transformation and cell growth regulation. Since MYC is a key regulator of stem cells, these studies have direct implications for stem cell models of prostate cancer formation.

    Additionally, the laboratory also has been leading efforts to apply novel biomarkers to human prostate tissues, to provide tissue banking for the prostate cancer research program, and to develop tissue microarrays and tissue microarray software.

    Lab:

    Dr. De Marzo's laboratory is focused on developing new insights into the molecular pathobiology of prostate cancer. For example, they are focused on determining the cell type of origin and the molecular mechanisms involved in neoplastic transformation in the prostate.

    His laboratory performs translational research to interrogate biomarker expression in human prostate tissues, where such biomarkers might aid the pathologist in making a diagnosis on challenging biopsy cases, help to predict outcome, help determine whether a given pathway alteration is present, or help to determine whether a drug has hit its target.

    Additionally, Dr. De Marzo's lab is involved in tissue banking, tissue microarray technology, tissue microarray software and database design, and image analysis of tissue microarrays.

    Dr. De Marzo's laboratory works very closely with the labs of William G. Nelson M.D., Ph.D., Srinivasan Yegnasubramanian M.D., Ph.D. and Karen Sfanos Ph.D. in a number of related research areas. The lab also collaborates extensively with Alan K. Meeker Ph.D., and Elizabeth Platz Sc.D. PSD, from the Johns Hopkins Bloomberg School of Public Health, and a range of other investigators both within and outside of Johns Hopkins.

    Selected Publications View all on PubMed

    1. Tan S, Sood A, Rahimi H, Wang W, Gupta N, Hicks J, Mosier S, Gocke CD, Epstein JI, Netto GJ, Liu W, Isaacs WB, De Marzo AM, Lotan T. "Rb Loss is Characteristic of Prostatic Small Cell Neuroendocrine Carcinoma." Clin Cancer Res. 2013 Dec 9. [Epub ahead of print]
    2. Canene-Adams K, Sfanos KS, Liang CT, Yegnasubramanian S, Nelson WG, Brayton C, De Marzo AM. "Dietary Chemoprevention of PhIP Induced Carcinogenesis in Male Fischer 344 Rats with Tomato and Broccoli." PLoS One. 2013 Nov 27;8(11):e79842. doi: 10.1371/journal.pone.0079842. eCollection 2013.
    3. Hurwitz LM, Heaphy CM, Joshu CE, Isaacs WB, Konishi Y, De Marzo AM, Isaacs SD, Wiley KE, Platz EA, Meeker AK. "Telomere length as a risk factor for hereditary prostate cancer." Prostate. 2014 Apr;74(4):359-64. doi: 10.1002/pros.22755. Epub 2013 Nov 28.
    4. Haffner MC, Mosbruger T, Esopi DM, Fedor H, Heaphy CM, Walker DA, Adejola N, Gürel M, Hicks J, Meeker AK, Halushka MK, Simons JW, Isaacs WB, De Marzo AM, Nelson WG, Yegnasubramanian S. "Tracking the clonal origin of lethal prostate cancer." J Clin Invest. 2013 Nov 1;123(11):4918-22. doi: 10.1172/JCI70354. Epub 2013 Oct 25.
    5. Darshan M, Zheng Q, Fedor HL, Wyhs N, Yegnasubramanian S, Lee P, Melamed J, Netto GJ, Trock BJ, De Marzo AM, Sfanos KS. "Biobanking of derivatives from radical retropubic and robot-assisted laparoscopic prostatectomy tissues as part of the prostate cancer biorepository network." Prostate. 2014 Jan;74(1):61-9. doi: 10.1002/pros.22730. Epub 2013 Sep 21.
  • Academic Affiliations & Courses +
  • Activities & Honors +

    Honors

    • Dean's List, University of Colorado, Boulder, 1982 - 1987
    • Alpha Omega Alpha (AOA) Society, 1993
    • Research and Clinical Fellowship, National Institutes of Health, Training Grant in Pathobiology of Cancer, 1997 - 1998
    • Harvey/Burroughs Welcome Clinician Scientist Award, The Johns Hopkins Medical Institutions, 1998
    • Mentored Clinician Scientist Development Award (K08), National Institutes of Health, National Cancer Institute, 1998
    • Stowell-Orbison Award for Research by a Pathologist-In-Training, International Academy of Pathology, 1998
    • Harvey/Burroughs Welcome Clinician Scientist Award, The Johns Hopkins Medical Institutions, 1999
    • Aegon Fellowship in Breast and Prostate Cancer Research, 2000
    • Achievement Award in Scientific Session: TMAJ, A Johns Hopkins Set of Open Source Software Tools to Manage a Multi-Organ, Scalable, Secure, Multi-User Tissue MicroArray Database., 2002 Meeting: Advancing Pathology Informatics, Imaging and the Internet, Pittsburgh, PA, 2002
    • Donald S. Coffey Prostate Cancer Foundation Physician/Scientist Award, 2004
    • STEP-UP Undergraduate Summer Research Program, National Institute of Diabetes and Digestive and Kidney Diseases, 2007
    • Faculty Teaching Award, Department of Urology, 2008 - 2009
    • Teacher of the Year, Pathobiology Graduate Program, 2008

    Memberships

    • American Association for the Advancement of Science, 1987
    • American Medical Association, 1987 - 1994
    • Alpha Omega Alpha, 1993
    • American Society of Clinical Pathologists, 1995
    • College of American Pathologists, 1995
    • American Urological Association, 1998
    • American Association for Cancer Research, 2001

    Professional Activities

    • Chief Medical Officer, Predictive Biosciences Inc., 2012
  • Videos & Media +
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