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Photo of Dr. Angelo DeMarzo

Angelo Michael DeMarzo, MD PhD

Associate Director of Cancer Research Pathology, SKCCC
Professor of Pathology

See Research on Pubmed

Male
Appointment Phone

410-955-2660

Primary Location

The Johns Hopkins Hospital

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Out-of-State & International Patients +
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Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

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Call +1-410-502-0773 (7a.m. to 6p.m., EST, Mon-Fri)

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Titles

  • Associate Director of Cancer Research Pathology, SKCCC
  • Director, Tissue Microarray Core Facility
  • Professor of Pathology
  • Professor of Oncology
  • Professor of Urology

Centers & Institutes

  • James Buchanan Brady Urological Institute
  • Sidney Kimmel Comprehensive Cancer Center

Expertise

Pathology, Prostate Cancer

Research Interests

Prostate cancer and inflammation; MYC, PTEN and prostate cancer; Biospecimen banking; Biomarker development; Tissue microarrays

Biography

Dr. Angelo De Marzo is a professor of pathology, oncology and urology at the Johns Hopkins School of Medicine. His areas of clinical expertise include pathology and prostate cancer. Dr. De Marzo serves as the associate director of Cancer Research Pathology at the Sidney Kimmel Comprehensive Cancer Center.

Dr. De Marzo founded the Tissue Microarray Core at Johns Hopkins, now known as the Oncology Tissue Services. He led it for a decade and now serves as an advisor to the core.

Dr. De Marzo's research interests include the molecular pathobiology of prostate cancer, biospecimen banking, biomarker development and tissue microarrays.

Dr. De Marzo received his B.A. in molecular, cellular and developmental biology and psychology from the University of Colorado at Boulder. He earned his M.D. and Ph.D. in experimental pathology from University of Colorado Health Sciences Center. He completed his residency in pathology at the Johns Hopkins School of Medicine and performed a fellowship at the Brady Urological Institute at Johns Hopkins. Dr. De Marzo joined the Johns Hopkins faculty in 1998.

Dr. De Marzo is Chief Medical Officer at Predictive Biosciences Inc., and serves on the editorial board of The Prostate and Cancer Prevention Research. He is the recipient of the 2004 Donald S. Coffey Prostate Cancer Foundation Physician/Scientist Award and is a member of various professional organizations, including the American Urological Association and the American Association for Cancer Research.

Languages

  • English

Memberships

American Association for Cancer Research, 2001-present.

American Urological Association, 1998- present.

American Society of Clinical Pathologists, 1995-present.

College of American Pathologists, 1995-present.

Alpha Omega Alpha, 1993-present.

American Association for the Advancement of Science, 1987- present.

American Medical Association, 1987-1994

Additional Resources

Additional Resources +
  • Education +

    Training

    • University of Colorado Health Sciences Center ( Denver CO ) (1994)
    • University of Colorado School of Medicine ( Denver CO ) (1993)

    Residencies

    • The Johns Hopkins Hospital/Pathology ( Baltimore MD ) (1997)

    Fellowships

    • The Johns Hopkins Hospital ( Baltimore MD ) (1998)

    Certifications

    • Anatomic Pathology, American Board of Pathology (1998)
  • Research & Publications +

    Research Summary

    Dr. De Marzo’s research focuses on prostate cancer, paying special attention to prevention. His research group has postulated that a common lesion often associated with inflammation—called proliferative inflammatory atrophy (PIA)—may represent a risk factor or precursor lesion to prostate cancer. This research has implications for prevention and chemoprevention of prostate cancer.

    Dr Marzo’s laboratory is also using genetically engineered mouse models and cell culture systems to study the role of the MYC oncogene in prostate cancer cell neoplastic transformation and cell growth regulation. Since MYC is a key regulator of stem cells, these studies have direct implications for stem cell models of prostate cancer formation.

    Additionally, the laboratory also has been leading efforts to apply novel biomarkers to human prostate tissues, to provide tissue banking for the prostate cancer research program, and to develop tissue microarrays and tissue microarray software.

    Selected Publications View all on PubMed

    1. Tan S, Sood A, Rahimi H, Wang W, Gupta N, Hicks J, Mosier S, Gocke CD, Epstein JI, Netto GJ, Liu W, Isaacs WB, De Marzo AM, Lotan T. “Rb Loss is Characteristic of Prostatic Small Cell Neuroendocrine Carcinoma.” Clin Cancer Res. 2013 Dec 9. [Epub ahead of print]
    2. Canene-Adams K, Sfanos KS, Liang CT, Yegnasubramanian S, Nelson WG, Brayton C, De Marzo AM. “Dietary Chemoprevention of PhIP Induced Carcinogenesis in Male Fischer 344 Rats with Tomato and Broccoli.” PLoS One. 2013 Nov 27;8(11):e79842. doi: 10.1371/journal.pone.0079842. eCollection 2013.
    3. Hurwitz LM, Heaphy CM, Joshu CE, Isaacs WB, Konishi Y, De Marzo AM, Isaacs SD, Wiley KE, Platz EA, Meeker AK. “Telomere length as a risk factor for hereditary prostate cancer.” Prostate. 2014 Apr;74(4):359-64. doi: 10.1002/pros.22755. Epub 2013 Nov 28.
    4. Haffner MC, Mosbruger T, Esopi DM, Fedor H, Heaphy CM, Walker DA, Adejola N, Gürel M, Hicks J, Meeker AK, Halushka MK, Simons JW, Isaacs WB, De Marzo AM, Nelson WG, Yegnasubramanian S. “Tracking the clonal origin of lethal prostate cancer.” J Clin Invest. 2013 Nov 1;123(11):4918-22. doi: 10.1172/JCI70354. Epub 2013 Oct 25.
    5. Darshan M, Zheng Q, Fedor HL, Wyhs N, Yegnasubramanian S, Lee P, Melamed J, Netto GJ, Trock BJ, De Marzo AM, Sfanos KS. “Biobanking of derivatives from radical retropubic and robot-assisted laparoscopic prostatectomy tissues as part of the prostate cancer biorepository network.” Prostate. 2014 Jan;74(1):61-9. doi: 10.1002/pros.22730. Epub 2013 Sep 21.

    Lab

    Dr. De Marzo's laboratory is focused on developing new insights into the molecular pathobiology of prostate cancer. For example, they are focused on determining the cell type of origin and the molecular mechanisms involved in neoplastic transformation in the prostate.

    His laboratory performs translational research to interrogate biomarker expression in human prostate tissues, where such biomarkers might aid the pathologist in making a diagnosis on challenging biopsy cases, help to predict outcome, help determine whether a given pathway alteration is present, or help to determine whether a drug has hit its target.

    Additionally, Dr. De Marzo's lab is involved in tissue banking, tissue microarray technology, tissue microarray software and database design, and image analysis of tissue microarrays.

    Dr. De Marzo's laboratory works very closely with the labs of William G. Nelson M.D., Ph.D., Srinivasan Yegnasubramanian M.D., Ph.D. and Karen Sfanos Ph.D. in a number of related research areas. The lab also collaborates extensively with Alan K. Meeker Ph.D., and Elizabeth Platz Sc.D. PSD, from the Johns Hopkins Bloomberg School of Public Health, and a range of other investigators both within and outside of Johns Hopkins.

  • Academic Affiliations & Courses +
  • Activities & Honors +

    Honors

    Faculty Teaching Award, Department of Urology, 2008-2009

    Teacher of the Year, Pathobiology Graduate Program, 2008

    STEP-UP Undergraduate Summer Research Program, National Institute of Diabetes and Digestive and Kidney Diseases, 2007

    Donald S. Coffey Prostate Cancer Foundation Physician/Scientist Award, 2004

    Achievement Award in Scientific Session: TMAJ, A Johns Hopkins Set of Open Source Software Tools to Manage a Multi-Organ, Scalable, Secure, Multi-User Tissue MicroArray Database. 2002 Meeting: Advancing Pathology Informatics, Imaging and the Internet, Pittsburgh, PA, 2002

    Aegon Fellowship in Breast and Prostate Cancer Research, 2000

    Harvey/Burroughs Welcome Clinician Scientist Award, The Johns Hopkins Medical Institutions, 1998 and 1999

    Mentored Clinician Scientist Development Award (K08), National Institutes of Health, National Cancer Institute, 1998

    Stowell-Orbison Award for Research by a Pathologist-In-Training, International Academy of Pathology, 1998

    Research and Clinical Fellowship, National Institutes of Health, Training Grant in Pathobiology of Cancer, 1997-1998

    Alpha Omega Alpha (AOA) Society, 1993

    Dean''s List, University of Colorado, Boulder, 1982-1987

    Professional Activities

    Chief Medical Officer, Predictive Biosciences Inc., 2012-present

    Editorial board member, The Prostate

    Editorial board member, Cancer Prevention Research

  • Videos & Media +
  • Upcoming Events +
  • Contact & Locations +

    Locations

    The Johns Hopkins Hospital
    600 N. Wolfe Street
    Hospital Main Entrance - Sheikh Zayed Tower
    Baltimore, MD 21287
    Appointment Phone: 410-955-2660
    Location Map

    Department/Division

    • Pathology

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