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Photo of Dr. Robert Brodsky

Robert Alan Brodsky, MD

Director, Division of Hematology
Professor of Medicine
Male
Appointment Phone

410-955-8964

Main Location

Johns Hopkins Sidney Kimmel Comprehensive Cancer Center

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Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

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Titles

  • Director, Division of Hematology
  • Professor of Medicine
  • Professor of Oncology

Centers & Institutes

  • Sidney Kimmel Comprehensive Cancer Center

Expertise

Aplastic Anemia, Bone Marrow Failure, Hematologic Malignancies, Hematology, Medical Oncology, Myelodysplastic Syndrome, Paroxysmal Nocturnal Hemoglobinuria

Research Interests

high-dose cyclophosphamide, aplastic anemia, paroxysmal nocturnal hemoglobinuria

Biography

    

Languages

  • English

Memberships

1994 American Society of Hematology

2001 International Society of Experimental Hematology

2004 Fellow - American College of Physicians

Clinical Trial Keywords

  • aplastic anemia, high-dose cyclophosphamide

Additional Resources

Additional Resources +
  • Education +

    Training

    • Hahnemann University Hospital (Philadelphia PA) (1989)

    Residencies

    • Vanderbilt University School of Medicine / Internal Medicine (Nashville TN) (1991)

    Fellowships

    • Johns Hopkins University School of Medicine / Oncology (Baltimore MD) (1997)
    • National Institutes of Health - Credentialing Services Section / Hematology (Bethesda MD) (1994)

    Certifications

    • American Board of Internal Medicine / Hematology (2006)
  • Research & Publications +

    Research Summary

    Dr. Brodsky's major clinical research involves the study of aplastic anemia, PNH and other bone marrow failure disorders. His research shows that immunoablative doses of cyclophosphamide, without bone marrow transplantation, can lead to durable complete remissions in severe aplastic anemia. The reason high-dose cyclophosphamide is able to ablate the effector cells without destroying hematopoietic stem cells is that the earliest stem cells (but not lymphocytes) contain high levels of aldehyde dehydrogenase conferring resistance to the cytoxic properties of cyclophosphamide. Dr. Brodsky and his colleagues in neurology and rheumatology are applying this approach in other severe autoimmune disorders including, scleroderma, myasthenia gravis, multiple sclerosis and autoimmune hematologic disorders.

    Dr. Brodsky's major laboratory interests relate to the study of normal and abnormal hematopoiesis. Specifically his lab studies PIG-A gene mutations in aplastic anemia. His group has developed a novel diagnostic assay for PNH based on the pore forming toxin (aeromonas hydrophila).

    Selected Publications

    1. Pu JJ, Brodsky RA. Paroxysmal Nocturnal Hemoglobinuria from Bench to Bedside. Clinical and Translational Science. 2011;4(3):219-24. PMID:21707954; PMCID:PMC3128433.
    2. Gladstone DE, Bolanos-Meade J, Huff CA, Zahurak M, Flinn I, Borrello I, Luznik L, Fuchs E, Kasamon Y, Matsui W, Powell J, Levitsky H, Brodsky RA, Ambinder R, Jones RJ, Swinnen LJ. High-dose cyclophosphamide and rituximab without stem cell transplant: a feasibility study for low grade B-cell, transformed and mantle cell lymphomas. Leuk Lymphoma. 2011; 52(11):2076-81. PMID: 21756035.
    3. Harrison DM, Gladstone DE, Hammond E, Cheng J, Jones RJ, Brodsky RA, Kerr D, McArthur JC, Kaplin A. Treatment of relapsing-remitting multiple sclerosis with highdose cyclophosphamide induction followed by glatiramer acetate maintenance. Mult Scler. 2012; 18(2):202-9. PMID 21865410.
    4. Johnston JJ, Gropman AL, Sapp JC, Teer JK, Martin JM, Liu CF, Yuan X, Ye Z, Cheng L, Brodsky RA, Biesecker LG. The Phenotype of A Germline Mutation in PIGA: The Gene Somatically Mutated in Paroxysmal Nocturnal Hemoglobinuria. Am J Hum Genet. 2012;90(2):295-300. PMID: 22305531.
    5. Pu JJ, Hu R, Mukhina GL, Carraway HE, McDevitt MA, Brodsky RA. The small population of PIG-A mutant cells in myelodysplastic syndromes do not arise from multipotent hematopoietic stem cells. Haematologica. 2012;97(8):1225-33. PMID: 22315493; PMCID: PMC3409821.
    6. Bolanos-Meade J, Fuchs EJ, Luznik L, Lanzkron SM, Gamper CJ, Jones RJ, Brodsky RA. HLA-haploidentical bone marrow transplantation with posttransplant cyclophosphamide expands the donor pool for patients with sickle cell disease. Blood. 2012;120(22):4285-9. PMID: 22955919; PMCID: PMC3507140
    7. Kasamon YL, Brodsky RA, Borowitz MJ, Ambinder RF, et al. Brief intensive therapy for older adults with newly diagnosed Burkitt or atypical Burkitt lymphoma/leukemia. Leuk Lymphoma. 2013;54(3):483-90. PMID: 22835045.
    8. DeZern AE, Styler MJ, Drachman D, Hummers L, Jones RJ, Brodsky RA. Repeated treatment for severe autoimmune diseases with high dose cyclophosphomide. American Journal of Blood Research. 2013;3(1):84-90. PMID: 23358715; PMCID: PMC3555191.
    9. Peter Hillmen, Petra Muus, Alexander Röth, Modupe O. Elebute, Antonio M. Risitano, Hubert Schrezenmeier, Jeffrey Szer, Paul Browne, Jaroslaw P. Maciejewski, Jörg Schubert, Alvaro Urbano-Ispizua, Carlos de Castro, Gérard Socié, Robert A. Brodsky. Long-term safety and efficacy of sustained eculizumab treatment in patients with paroxysmal nocturnal haemoglobinuria. Br J Haematol. 2013; 162(1):62-73. PMID: 23617322; PMCID: PMC3744747.
    10. DeZern AE, Pu J, McDevitt MA, Jones RJ, Brodsky RA. Burst-Forming Unit-Erythroid Assays (BFU-E) To Distinguish Cellular Bone Marrow Failure Disorders. Exp Hematology. 2013;41(9):808-16. PMID: 23660070; PMCID: PMC3769493.
    11. Yuan X, Braunstein E, Ye Z, Liu C, Chen G, Zhou J, Cheng L, Brodsky RA. Generation of GPI anchor protein deficient blood celss from human induced pluripotent stem cells. Stem Cells Translational Medicine. 2013; 2(11):819-29. PMID: 24113066; PMCID: PMC3808197.
    12. Varela JC, Brodsky RA. Paroxysmal nocturnal hemoglobinuria and the age of therapeutic complement inhibition. Expert Rev Clin Immunol. 2013;9(11):1113-24. PMID: 24168416.
    13. Belet S, Fieremans N, Yuan X, Van Esch H, Verbeeck J, Ye Z, Cheng L, Brodsky BR, Hu H, Kalscheuer VM, Brodsky RA, Froyen G. Early Frameshift Mutation in PIGA Identified in a Large XLID Family Without Neonatal Lethality. Hum Mutat. 2014;35(3):350-5. PMID: 24357517.
    14. Schrezenmeier H, Muus P, Socié G, Szer J, Urbano-Ispizua A, Maciejewski JP, Brodsky RA, Bessler M, Kanakura Y, Rosse W, Khursigara G, Bedrosian C, Hillmen P. Baseline characteristics and disease burden in patients in the international paroxysmal nocturnal hemoglobinuria registry. Haematologica. 2014;99(5):922-9. PMID: 24488565; PMCID: PMC4008114.
    15. DeZern AE, Symons HJ, Resar LS, Borowitz MJ, Armanios MY, Brodsky RA. Detection of paroxysmal nocturnal hemoglobinuria clones to exclude inherited bone marrow failure syndromes. Eur J Haematol. 2014:92(6):467-70. PMID: 24612308.
    16. Showel MM, Brodsky RA, Tsai HL, Briel KM, Kowalski J, Griffin CA, Jones RJ. Isolated Clonal Cytogenetic Abnormalities after High-Dose Therapy. Biol Blood Marrow Transplant 2014;20(8):1130-8. PMID: 24732780.
    17. Smith C, Gore A, Yan W, Abalde-Atristain L, Li Z, He C, Wang Y, Brodsky RA, Zhang K, Cheng L, Ye Z. Whole-Genome sequencing analysis reveals high specificity of CRISPR/Cas9 and TALEN-Based genome editing in human iPSCs. Cell Stem Cell 2014;15(1):12-3. PMID: 24996165.
    18. Park JC, Pratz CF, Tesfaye A, Brodsky RA, Antonarakis ES. The Effect of Therapeutic Anticoagulation on Overall Survival in Men Receiving First-Line Docetaxel Chemotherapy for Metastatic Castration-Resistant Prostate Cancer. Clin Genitourin Cancer. 2014. pii: S1558-7673(14)00118-9. PMID: 24999166 [Epub ahead of print]
    19. DeZern AE, Uknis M, Yuan X, Mukhina GL, Varela J, Saye J, Pu J, Brodsky RA. Complement blockade with a C1 esterase inhibitor in paroxysmal nocturnal hemoglobinuria. Exp Hematol. 2014. pii: S0301-472X(14)00241-0. PMID: 25034232 [Epub ahead of print]
    20. Brodsky RA. Paroxysmal Nocturnal Hemoglobinuria. Blood. 2014 [in press]
  • Academic Affiliations & Courses +
  • Activities & Honors +

    Honors

    1988 Chairman's Invitational Honors Program

    1989 Samuel Levit, M.D. Award - Outstanding Clinical and Humanitarianism in the care of Medical Patients

    1989 James P. Fullin Memorial Award - Outstanding Clinical and Academic Performance in Hematology/Oncology

    1989 Academic Honors: Oncology

    1989 Academic Distinctions: Medicine, Neurology

    1994 American Society of Hematology Travel Award

    1996 1st Prize, Johns Hopkins Oncology Center Fellow Research Day

    1996 American Society of Hematology Travel Award

    1997 Thomas E. Sandefur, Jr. Fellow in Stem Cell Research

    1998 Junior Faculty Scholar, American Society of Hematology

    2000 Leukemia and Lymphoma Society of America Scholar

    2013 Clinical Research Forum: Clinical Research Achievement Award for 2nd most important clinical research paper in medicine; HLA-haploidentical bone marrow transplantation with posttransplant cyclophosphamide expands the donor pool for patients with sickle cell disease. Blood. 2012

  • Videos & Media +

    Videos

    Getting off the Ground

    Alvin Myerbergs generosity takes HiCy studies at Hopkins to the next level.

    Johns Hopkins Medicine: Aplastic Anemia

    A Remarkable Journey

    Throughout its history, Johns Hopkins has always been willing to head into unchartered territory. Fueled by philanthropy, we have gone places farther than envisioned and more rewarding than we could have possibly imagined. Along the way, we may face challenges. No matter what, we never give up. We believe in the potential of the next generation and in the wisdom of experience. From the microscopic level of the cell to the outer limits of space, every day we transform our world and you make this remarkable journey possible.

  • Events +
  • Contact & Locations +

    Locations

    Johns Hopkins Sidney Kimmel Comprehensive Cancer Center
    401 N. Broadway
    Baltimore, MD 21231
    Phone: 410-502-2546
    Appointment Phone: 410-955-8964
    Fax: 410-955-0185
    Location Map

    Department/Division

    • Medicine - Hematology

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