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Barbara Jean Crain, MD

Director, Autopsy Service
Associate Professor of Pathology
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Main Location

The Johns Hopkins Hospital

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Call +1-410-502-7683 (7a.m. to 6p.m., EST, Mon-Fri)

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  • Director, Autopsy Service
  • Co-Investigator, Neuropathy Core D
  • Associate Professor of Pathology
  • Associate Professor of Neurology
  • Associate Professor of Oncology

Centers & Institutes

  • Morris K. Udall Parkinson's Disease Research Center



Research Interests

Neuronal vulnerability in different disease states; Bone marrow cells after transplantation; Animal models of stroke


Dr. Barbara Crain is an associate professor of pathology at the Johns Hopkins University School of Medicine. Her areas of clinical expertise include neurodegenerative and vascular diseases. Dr. Crain serves as the director of the Autopsy Service at the Johns Hopkins School of Medicine. She is also a member of the research team at the Morris K. Udall Parkinson''s Disease Research Center of Excellence.

Dr. Crain earned her Ph.D. in anatomy (neuroanatomy) and her M.D. from Duke University School of Medicine. She completed her residency in pathology and performed a fellowship in neuropathology, also at Duke University School of Medicine.

Dr. Crain's main research interests include patterns and mechanisms of neuronal vulnerability in different disease states.

Dr. Crain has served as chair of the neuropathology committee of the College of American Pathologists. She was a co-author of criteria for the diagnosis of Alzheimer’s disease for the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD). Dr. Crain has been on the editorial boards of the Journal of Neuropathology and Experimental Neurology and the Archives of Pathology and Laboratory Medicine.


  • English


College of American Pathologists

United States and Canadian Academy of Pathology

American Association of Neuropathologists

Additional Resources +
  • Education +


    • Duke University School of Medicine (Durham NC ) (1979)


    • Duke University School of Medicine / Pathology (Durham NC ) (1982)


    • Duke University School of Medicine / Neuropathology (Durham NC ) (1982)


    • Anatomic Pathology, American Board of Pathology (1983)
    • Neuropathology, American Board of Pathology (1983)
  • Research & Publications +

    Research Summary

    Dr. Crain’s research interests concern patterns and mechanisms of neuronal vulnerability in different disease states, particularly in the areas of neurodegenerative disease and stroke. She collaborates with the Alzheimer's Disease Research Center, the Parkinson's Center, and the Huntington's Center.

    Dr. Crain is also interested in the fate of bone marrow cells after transplantation. She has examined the brains of female patients who received bone marrow transplants from males and found neurons containing Y-chromosomes. Occasional glial and blood vessels cells also contain Y-chromosomes. She is also collaborating with faculty in Anesthesiology and Critical Care Medicine on studies of animal models of stroke.

    Selected Publications

    1. Mezey, E., Key, S., Vogelsang, G., Szalayova, I., Lange, G. D., and Crain, B. “Transplanted bone marrow generates new neurons in human brains.” Proc Natl Acad Sci U S A. 100:1364-9, 2003.

    2. Hatanpaa, K.J., Blass, D.M., Pletnikova, O., Crain, B.J., Bigio, E.H., Hedreen, J.C., White, I.C.L., Troncoso, J.C. “Most cases of dementia with hippocampal sclerosis may represent frontotemporal dementia.” Neurology. 63:538-542, 2004.

    3. Toung, T.J.K., Chang, Y., Williams, M., Crain, B.J., Traystman, R.J., Bhardwaj, A. “Experimental spinal cord ischemia: model characterization and improved outcome with arterial hypertension.” Crit Care Med. 32:1346-51, 2004.

    CORE Facilities

    Neuropathy Core D

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    The Johns Hopkins Hospital
    600 N. Wolfe Street
    Sheikh Zayed Tower
    Baltimore, MD 21287
    Phone: 410-502-5167
    Appointment Phone: 410-502-5167
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    • Pathology

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