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Barbara J. Crain, M.D., Ph.D.

Director, Autopsy Service
Associate Professor of Pathology


Appointment Phone


Main Location

The Johns Hopkins Hospital

Out-of-State & International Patients +
Out of State Patients

Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

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International Patients

Call +1-410-502-7683 (7a.m. to 6p.m., EST, Mon-Fri)

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  • Director, Autopsy Service
  • Co-Investigator, Neuropathy Core D
  • Associate Professor of Pathology
  • Associate Professor of Neurology
  • Associate Professor of Oncology

Centers & Institutes



The Johns Hopkins Hospital

Appointment Phone: 410-502-5167

600 N. Wolfe Street
Sheikh Zayed Tower
Baltimore, MD 21287 map
Phone: 410-502-5167



Research Interests

Animal models of stroke; Bone marrow cells after transplantation; Neuronal vulnerability in different disease states


Dr. Barbara Crain is an associate professor of pathology at the Johns Hopkins University School of Medicine. Her areas of clinical expertise include neurodegenerative and vascular diseases. Dr. Crain serves as the director of the Autopsy Service at the Johns Hopkins School of Medicine. She is also a member of the research team at the Morris K. Udall Parkinson''s Disease Research Center of Excellence.

Dr. Crain earned her Ph.D. in anatomy (neuroanatomy) and her M.D. from Duke University School of Medicine. She completed her residency in pathology and performed a fellowship in neuropathology, also at Duke University School of Medicine.

Dr. Crain's main research interests include patterns and mechanisms of neuronal vulnerability in different disease states.

Dr. Crain has served as chair of the neuropathology committee of the College of American Pathologists. She was a co-author of criteria for the diagnosis of Alzheimer’s disease for the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD). Dr. Crain has been on the editorial boards of the Journal of Neuropathology and Experimental Neurology and the Archives of Pathology and Laboratory Medicine. more

    Additional Information

  • Education +
  • Research & Publications +

    Research Summary

    Dr. Crain’s research interests concern patterns and mechanisms of neuronal vulnerability in different disease states, particularly in the areas of neurodegenerative disease and stroke. She collaborates with the Alzheimer's Disease Research Center, the Parkinson's Center, and the Huntington's Center.

    Dr. Crain is also interested in the fate of bone marrow cells after transplantation. She has examined the brains of female patients who received bone marrow transplants from males and found neurons containing Y-chromosomes. Occasional glial and blood vessels cells also contain Y-chromosomes. She is also collaborating with faculty in Anesthesiology and Critical Care Medicine on studies of animal models of stroke.

    CORE Facilities

    Neuropathy Core D

    Selected Publications

    1. Mezey, E., Key, S., Vogelsang, G., Szalayova, I., Lange, G. D., and Crain, B. "Transplanted bone marrow generates new neurons in human brains." Proc Natl Acad Sci U S A. 100:1364-9, 2003.

    2. Hatanpaa, K.J., Blass, D.M., Pletnikova, O., Crain, B.J., Bigio, E.H., Hedreen, J.C., White, I.C.L., Troncoso, J.C. "Most cases of dementia with hippocampal sclerosis may represent frontotemporal dementia." Neurology. 63:538-542, 2004.

    3. Toung, T.J.K., Chang, Y., Williams, M., Crain, B.J., Traystman, R.J., Bhardwaj, A. "Experimental spinal cord ischemia: model characterization and improved outcome with arterial hypertension." Crit Care Med. 32:1346-51, 2004.

  • Academic Affiliations & Courses +
  • Activities & Honors +


    • American Association of Neuropathologists
    • College of American Pathologists
    • United States and Canadian Academy of Pathology
  • Videos & Media +
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