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Daniel Philip Judge, M.D.
Director, Center for Inherited Heart Disease
Associate Professor of Medicine
Expertise: Amyloid Diseases, Arrhythmogenic Right Ventricular Dysplasia, Cardiomyopathy, Cardiovascular Disease, Congestive Heart Failure, Heart Disease, Heart Failure, Heart Transplant, Hypertrophic Cardiomyopathy, Inherited Heart Diseases, Marfan Syndrome, Muscular Dystrophies, Peripartum Cardiomyopathy, Valvular Heart Disease, Vascular Malformations ...read more
Research Interests: Inherited cardiovascular diseases; Amyloid, Familial; Familial Mitral Valve Disease; ARVD - Genetics and Pathogenesis; Muscular Dystrophies ...read more
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The Johns Hopkins Hospital
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Baltimore, MD 21287 map
Johns Hopkins Outpatient Center
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Daniel P. Judge is a cardiologist specializing in inherited diseases of the heart, including heart valve disorders, cardiomyopathy, amyloidosis, and Marfan syndrome. He founded the JHU Center for Inherited Heart Disease at the Johns Hopkins School of Medicine and currently serves as its medical director.
Dr. Judge studied chemistry at College of the Holy Cross in Worcester, Massachusetts, and graduated from the University of Pennsylvania School of Medicine in 1993. He completed his residency in medicine and a fellowship in cardiology specializing in heart failure and transplant at Johns Hopkins Hospital. Dr. Judge joined the Johns Hopkins faculty in 2000 and is currently an associate professor of medicine in Cardiology. He is active as a faculty member in patient care, research and teaching with an overall focus on cardiovascular genetics.
Dr. Judge’s current research includes inherited forms of heart disease that cause cardiomyopathy, heart failure or structural heart problems. He also focuses on cardiovascular genetic disorders and on translating basic research discoveries into clinical practice. One area of his research is to understand the role of genetic mutations in Arrhythmogenic Right Ventricular Dysplasia (ARVD), an inherited heart condition that results in sudden cardiac death and right ventricular heart dysfunction. He was recently able to identify a new factor that influences cell division in the heart and is working with this factor as a potential treatment for heart failure. He is also participating in several clinical trials testing new therapies for inherited cardiac amyloidosis.
Dr. Judge holds patents related to medical methods and procedures and is the author of at least 100 peer-reviewed articles. He is board-certified in Advanced Heart Failure & Transplant Cardiology, and directs the post-doctoral fellowship in this subspecialty.
- Director, Center for Inherited Heart Disease
- Associate Professor of Medicine
- MD; Medicine, Hospital of the University of Pennsylvania (1993)
- Johns Hopkins University School of Medicine / Internal Medicine (1996)
- Johns Hopkins University School of Medicine / Cardiology (2000)
- American Board of Internal Medicine / Advanced Heart Failure and Transplant Cardiology (2014)
- American Board of Internal Medicine / Cardiovascular Disease (1999, 2013)
Research & Publications
For the past decade, Dr. Judge’s lab has investigated the genetic basis and pathogenesis of inherited forms of cardiomyopathy. Laboratory-based research projects include next-generation DNA sequencing applications, pluripotent stem-cells, and translational therapies to treat cardiomyopathy and heart failure.
Lab Website: Judge Lab
Clinical Trial KeywordsTTR Amyloidosis, LMNA Cardiomyopathy
Maurer MS, Grogan DR, Judge DP, Mundayat R, Packman J, Lombardo I, Quyyumi AA, Aarts J, Falk RH. "Tafamidis in Transthyretin Amyloid Cardiomyopathy: Effects on Transthyretin Stabilization and Clinical Outcomes." Circulation: Heart Failure 2015; 8:519-26.
Shenje LT*, Andersen P*, Halushka MK, Lui C, Fernandez L, Collin GB, Amat-Alarcon N, Meschino W, Cutz E, Chang K, Yonescu R, Batista DAS, Chen Y, Chelko S, Crosson JE, Scheel J, Vricella L, Craig BD, Marosy BA, Mohr DW, Hetrick KN, Romm JM, Scott AF, Valle D, Naggert JK, Kwon C, Doheny KF, Judge DP. "Mutations in Alström protein impair terminal differentiation of cardiomyocytes." Nature Communications 2014; 5:3426.
Leung DG, Herzka DA, Thompson WR, He B, Bibat G, Tennekoon G, Russell SD, Schuleri KH, Lardo AC, Kass DA, Thompson RE, Judge DP*, Wagner KR*. (* co-last and co-corresponding authors) "Sildenafil does not improve cardiomyopathy in Duchenne/Becker muscular dystrophy." Annals of Neurology 2014; 7:541-.
Asimaki A, Kapoor S, Plovie E, Arndt AK, Adams E, Liu ZZ, James CA, Judge DP, Calkins H, Churko J, Wu JC, MacRae CA, Kleber AG, Saffitz JE. "An in-vivo drug screen in zebrafish identifies a novel modulator of intercalated disc remodeling in arrhythmogenic cardiomyopathy." Science Translational Medicine 2014; 6:240ra74.
Kim C, Wen J, Wong J, Wang S, Wang C, Spiering S, Kan NG, Forcales S, Puri PL, Leone TC, Marine JE, Judge DP, Chen HSV. "Inducing arrhythmogenic right ventricular dysplasia phenotype with patient-specific iPSCs and a lipogenic cocktail." Nature 2013; 494:105-110.
Judge DP "Use of Genetics in the Clinical Evaluation of Cardiomyopathy" JAMA 2009; 302:2471-76.
Benjamin S. Brooke; Jennifer P. Habashi; Daniel P. Judge; Nishant Patel; Bart Loeys; Harry C. Dietz III. Angiotensin II blockade and aortic-root dilation in Marfan's syndrome. New England Journal of Medicine. 2008;358(26):2787-2795.
Ronald D. Cohn; Christel Van Erp; Jennifer P. Habashi; Arshia A. Soleimani; Erin C. Klein; Matthew T. Lisi; Matthew Gamradt; Colette M. Ap Rhys; Tammy M. Holm; Bart L. Loeys; et al. Angiotensin II type 1 receptor blockade attenuates TGF-β-induced failure of muscle regeneration in multiple myopathic states. Nature Medicine. 2007;13(2):204-210.
Jennifer P. Habashi; Daniel P. Judge; Tammy M. Holm; Ronald D. Cohn; Bart L. Loeys; Timothy K. Cooper; Loretha Myers; Erin C. Klein; Guosheng Liu; Carla Calvi; et al. Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome. Science. 2006;312(5770):117-121.
Bart L. Loeys; Junji Chen; Enid R. Neptune; Daniel P. Judge; Megan Podowski; Tammy Holm; Jennifer Meyers; Carmen C. Leitch; Nicholas Katsanis; Neda Sharifi; et al. A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2. Nature Genetics. 2005;37(3):275-281.
Daniel P. Judge; Nancy J. Biery; Douglas R. Keene; Jessica Geubtner; Loretha Myers; David L. Huso; Lynn Y. Sakai; Harry C. Dietz. Evidence for a critical contribution of haploinsufficiency in the complex pathogenesis of Marfan syndrome. Journal of Clinical Investigation. 2004;114(2):172-181.
Activities & Honors
- Osler Science and Medicine Teaching Award, Johns Hopkins, 2005
- George Householder III Award in Cardiovascular Research, University of Pennsylvania, 1993
- Four Schools Physician-Scientist Training Program, 1991 - 1999
- Graduation cum laude, College of the Holy Cross, 1998
- Phi Beta Kappa, College of the Holy Cross, 1988
- American Heart Association
- Heart Failure Society of America
- Heart Rhythm Society
- National Marfan Foundation
Videos & Media
Lectures and Presentations
New diagnostic and therapeutic strategies for cardiac amyloidosis
Medical Grand Rounds (01/01/2015)
New approaches for the diagnosis and treatment of cardiac amyloidosis
Cardiomyopathy Genetics in 2012
Use of Genetics in the Clinical Practice of Heart Failure
Medical Grand Rounds (01/01/2009)
The Expanding Role for Genetic Evaluation in Cardiomyopathy
Pathology Grand Rounds (01/01/2008)
Clinical Genetic Testing for Cardiomyopathy
A 44 Year-Old Woman with Familial Cardiomyopathy and Premature Aging
Medical Grand Rounds (01/01/2004)
Genetic Forms of Vascular Diseases
Cardiology Grand Rounds (01/01/2003)
Marfan Syndrome: New Insights into Pathogenesis
Cardiology Grand Rounds (01/01/2002)
Familial Dilated Cardiomyopathy
Cardiology Grand Rounds (01/01/2001)