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Frank John Frassica, MD

Professor of Orthopaedic Surgery

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The Johns Hopkins Hospital

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  • Professor of Orthopaedic Surgery
  • Professor of Oncology


Bone Cancer, Bone Tumors, Musculoskeletal Disorders, Orthopaedic Oncology, Orthopaedic Surgery, Orthopaedics, Soft Tissue Tumors

Research Interests

Benign and malignant soft tissue masses; Benign and malignant bone tumors; Metastatic bone disease; Multiple myeloma metabolic diseases such as Pagets disease


Dr. Frank J. Frassica is a professor of orthopaedic surgery and oncology at the Johns Hopkins School of Medicine. His areas of specialization include the treatment of musculoskeletal trauma and bone and soft tissue cancers.

Dr. Frassica received his M.D. in 1982 from the Medical University of South Carolina College of Medicine in Charleston, SC. After a residency in orthopaedic surgery in 1983 at the National Capital Consortium, he completed a second residency in orthopaedic surgery and a fellowship in orthopaedic oncology at the Mayo Clinic in Rochester, MN, in 1988.

In 2000, Dr. Frassica joined the Johns Hopkins faculty as director of the Department of Orthopaedic Surgery, a role he served until 2011.

Dr. Frassica is certified by the American Board of Orthopaedic Surgery. He has received numerous teaching awards, and has written over 50 book chapters and co-authored four books on general Orthopaedics. He serves as editor of Orthopaedics, Journal of American Academy of Orthopaedic Surgeons and Hyperguide Orthopaedic Review Course, and is on the Editorial Board of Orthopaedic Oncology Journal American Academy of Orthopaedic Surgeons and Orthopedics Today.


  • English

Additional Resources

Additional Resources +
  • Education +


    • Medical University of South Carolina College of Medicine (Charleston SC) (1982)


    • Mayo Clinic Medical School College of Medicine / Orthopaedic Surgery (Rochester MN) (1988)


    • Mayo Clinic Medical School College of Medicine / Oncology (Rochester MN) (1988)


    • American Board of Orthopaedic Surgery / Orthopedic Surgery (2011)
  • Research & Publications +

    Research Summary

    Dr. Frassica’s extensive research interests include musculoskeletal disorders, orthopaedic surgery and orthopaedic oncology, and soft tissue tumors.

    Selected Publications View all on PubMed

    1. Schubert CD, Frassica FJ, Attar S, Deune EG. “Case Report: Rotational vascularized tibiaplasty after oncologic resection and major wound healing problems: A Novel Technique.” Eplasty. 2013 Aug 19; 13: e43
    2. Biermann JS, Adkins DR, Agulnik M, Benjamin RS, Brigman B, Butrynski JE, Cheong D, Chow W, Curry WT, Frassica DA, Frassica FJ, Hande KR, Hornicek FJ, Jones RL, Mayerson J, McGarry SV, McGrath B, Morris CD, O'Donnell RJ, Randall RL, Santana VM, Satcher RL, Siegel HJ, von Mehren M, Bergman MA, Sundar H. “Bone cancer.” J Natl Compr Canc Netw. 2013 Jun 1; 11(6): 688-723.
    3. Zhen G, Wen C, Jia X, Li Y, Crane JL, Mears SC, Askin FB, Frassica FJ, Chang W, Yao J, Carrino JA, Cosgarea A, Artemov D, Chen Q, Zhao Z, Zhou X, Riley L, Sponseller P, Wan M, Lu WW, Cao X. “Inhibition of TGF-β signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis.” Nat Med. 2013 Jun; 19(6):704-12. doi: 10.1038/nm.3143. Epub 2013 May 19.
    4. Thawait SK, Thawait GK, Frassica FJ, Andreisek G, Carrino JA, Chhabra A. “A systematic approach to magnetic resonance imaging evaluation of epiphyseal lesions.” Magn Reson Imaging. 2013 Apr; 31(3): 418-31. doi: 10.1016/j.mri.2012.08.006. Epub 2012 Oct 25.
    5. Xian L, Wu X, Pang L, Lou M, Rosen CJ, Qiu T, Crane J, Frassica F, Zhang L, Rodriguez JP, Xiaofeng Jia, Shoshana Yakar, Shouhong Xuan, Argiris Efstratiadis, Mei Wan, Xu Cao. “Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells.” Nat Med. 2012 Jul; 18(7): 1095-101. doi: 10.1038/nm.2793.
  • Academic Affiliations & Courses +
  • Activities & Honors +


    Distinguished Alumnus Award, Medical University of South Carolina, 2010

    Professional Activities

    Editor, Orthopaedics

    Editor, Journal of American Academy of Orthopaedic Surgeons

    Editor, Hyperguide Orthopaedic Review Course

    Editorial board member, Orthopaedic Oncology Journal

    Editorial board member, American Academy of Orthopaedic Surgeons

    Editorial board member, Orthopedics Today

  • Videos & Media +
  • Events +
  • Contact & Locations +


    The Johns Hopkins Hospital
    600 N. Wolfe Street
    Hospital Main Entrance - Sheikh Zayed Tower
    Baltimore, MD 21287
    Phone: 410-502-2698
    Appointment Phone: 410-502-2698
    Fax: 410-955-1719
    Location Map
    Johns Hopkins Bayview Medical Center
    4940 Eastern Avenue
    Baltimore, MD 21224
    Appointment Phone: 410-550-7800
    Location Map


    • Orthopaedic Surgery

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