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Photo of Dr. Michael Carducci

Michael Anthony Carducci, M.D.

AEGON Professor of Prostate Cancer Research
Professor of Oncology

Male

Appointment Phone

410-955-8964

Main Location

Johns Hopkins Sidney Kimmel Comprehensive Cancer Center

Out-of-State & International Patients +
Out of State Patients

Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

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International Patients

Call +1-410-502-7683 (7a.m. to 6p.m., EST, Mon-Fri)

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Titles

  • AEGON Professor of Prostate Cancer Research
  • Co-Director, Prostate Cancer/GU Oncology Program
  • Co-Director, Chemical Therapeutics
  • Professor of Oncology
  • Professor of Urology

Centers & Institutes

Departments

  • Oncology - Chemical Therapeutics
  • Urology
  • Medicine at Sibley Memorial Hospital

Locations

Johns Hopkins Sidney Kimmel Comprehensive Cancer Center

Appointment Phone: 410-955-8964

401 N. Broadway
Baltimore, MD 21231 map
Phone: 410-614-3977

Sibley Memorial Hospital

Appointment Phone: 202-660-6500

5255 Loughboro Road NW
Washington, DC 20016 map

Expertise

Bladder Cancer, Clinical Trials, Kidney Cancer, Medical Oncology , Pain and Palliative Care - Oncology, Prostate Cancer, Testicular Cancer, Urological Oncology, Urology

Research Interests

Development and Evaluation of New Therapies for Urologic Cancers

Biography

Dr. Michael Carducci is a professor of urology and oncology at the Johns Hopkins School of Medicine. He is co-leader of the Prostate Cancer / Genitourinary Oncology Program and co-leader of the Chemical Therapeutics Program at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins.

Dr. Carducci received his undergraduate degree from Georgetown University and his medical degree from Wayne State University School of Medicine. He completed an internal medicine internship, residency and chief residency at the University of Colorado Health Sciences Center. He went on to complete medical oncology and research fellowships at the Johns Hopkins Oncology Center at The Johns Hopkins Hospital.

A translational researcher, Dr. Carducci directs a laboratory program focused on the re-expression of epigenetically silenced genes in cancer cells via the use of small molecules targeting DNA methyltransferases and histone deacetylases, and manages a portfolio of clinical trials targeted at introducing these small molecules into cancer treatment. Overall, his laboratory and clinical research focus is on the development and evaluation of new therapies for urologic cancers.

A fellow of the American College of Physicians, Dr. Carducci is a member of several professional organizations, including the American Association for Cancer Research (AACR), American Society of Clinical Oncology (ASCO) and American Urological Association (AUA). Dr. Carducci serves as the principal investigator for a number of National Cancer Institute-supported clinical trials and leads the Johns Hopkins site for the Department of Defense Prostate Cancer Clinical Trials Consortium grant. In addition, he has received peer-reviewed funding for his laboratory and clinical research from the Department of Defense and the Prostate Cancer Foundation.

He is the chair of the Prostate Cancer Subcommittee of the Genitourinary Oncology Committee of ECOG and serves as an alternate to the GU Steering Committee for the National Cancer Institute. Dr. Carducci is also a full member of the Investigational Drug Steering Committee for the NCI. Within ASCO, he is currently chair of the Scientific Program Committee and has previously served on the Cancer Education, Scientific Program and Grants Selection Committees.

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    Additional Information

  • Education +

    Degrees

    • Wayne State University School Of Medicine / M.D. (1988)

    Fellowships

    • Johns Hopkins University School of Medicine / Oncology (1992)
    • Johns Hopkins University School of Medicine / Oncology (1995)

    Certifications

    • American Board of Internal Medicine / Internal Medicine (1991, 2011)
    • American Board of Internal Medicine / Medical Oncology (1995, 2005)
  • Research & Publications +

    Research Summary

    Dr. Carducci's research focus is on the development and evaluation of new therapies for genitourinary cancers, specifically prostate and renal cancers. Areas of particular interest are bone-targeted therapies, epigenetic strategies, as well as general early phase drug development leading to first-in-human clinical trials.

    Clinical Trials:

    A Study Of the Effectiveness Of Pomegranate Pills in Men With Prostate Cancer Before Prostatectomy

    Simultaneous Care: Linking Palliation to Clinical Trials

    Study of Everolimus Added to Combined Hormonal and Radiation Therapy for High Risk Prostate Cancer

    Temsirolimus and Vorinostat in Treating Patients With Metastatic Prostate Cancer

    Effects of Two Doses of MPX Capsules on Rising Prostate-specific Antigen Levels in Men Following Initial Therapy for Prostate Cancer

    Romidepsin in Treating Patients With Lymphoma, Chronic Lymphocytic Leukemia, or Solid Tumors With Liver Dysfunction

    Veliparib, Paclitaxel, and Carboplatin in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery and Liver or Kidney Dysfunction

    Entinostat and Aldesleukin in Treating Patients With Metastatic Kidney Cancer


    Clinical Trial Keywords: Phase I, Prostate Cancer, Kidney Cancer

    Selected Publications

    1. Armstrong AJ, Netto GJ, Rudek MA, Halabi S, Wood DP, Creel PA, Mundy K, Davis SL, Wang T, Albadine R, Schultz L, Partin AW, Jimeno A, Fedor H, Febbo PG, George DJ, Gurganus R, De Marzo AM, Carducci MA. "A pharmacodynamic study of rapamycin in men with intermediate- to high-risk localized prostate cancer." Clin Cancer Res. 2010 Jun 1;16(11):3057-3066.
    2. Cetin K, Beebe-Dimmer JL, Fryzek JP, Markus RE, Carducci MA. "Recent time trends in the epidemiology of stage IV prostate cancer in the United States: analysis of data from the Surveillance, Epidemiology, and End Results Program." Urology. 2010 Jun;75(6):1396-1404.
    3. DiPaola RS, Chen YH, Stein M, Vaughn D, Patrick-Miller L, Carducci M, Roth B, White E, Wilding G. "A randomized phase II trial of mitoxantrone, estramustine and vinorelbine or bcl-2 modulation with 13-cis retinoic acid, interferon and paclitaxel in patients with metastatic castrate-resistant prostate cancer: ECOG 3899." J Transl Med. 2010;8:20.
    4. Franke RM, Carducci MA, Rudek MA, Baker SD, Sparreboom A. "Castration-dependent pharmacokinetics of docetaxel in patients with prostate cancer." J Clin Oncol. 2010 Oct 20;28(30):4562-4567.
    5. Kachhap SK, Rosmus N, Collis SJ, Kortenhorst MS, Wissing MD, Hedayati M, Shabbeer S, Mendonca J, Deangelis J, Marchionni L, Lin J, Hoti N, Nortier JW, DeWeese TL, Hammers H, Carducci, MA. "Downregulation of homologous recombination DNA repair genes by HDAC inhibition in prostate cancer is mediated through the E2F1 transcription factor." PLoS One. 2010;5(6):e11208.
  • Academic Affiliations & Courses +
  • Activities & Honors +

    Honors

    • Salutatorian, Bishop Moore High School, 1979
    • Alpha Sigma Nu, Jesuit Honor Society, 1982
    • Alpha Omega Alpha, 1986
    • Distinguished Service Award, Wayne State University School of Medicine, 1988
    • M.D. with High Distinction, Wayne State University, 1988
    • Housestaff Teaching Award, Department of Medicine University of Colorado Health Sciences Center, 1991
    • Catherine S. and Isaac Hecht Award for Cancer Research, 1995 - 1997
    • Merit Award Recipient, American Society of Clinical Oncology, 1995
    • Third Prize, 1995 American Urological Association/CaP CURE Contest,, 1995
    • Wellcome Oncology Clinical Research Scholar, American Association for Cancer Research, 1995
    • Young Investigator Award, American Society of Clinical Oncology, 1995
    • Second Prize, American Urological Association/CaP CURE Contest, 1996
    • Osler Medicine Housestaff Teaching Award, Department of Medicine, The Johns Hopkins University School of Medicine, 1997
    • Talma Eykman Foundation Award to Fleur van de Geijn (Dr. Carducci- Mentor) for outstanding research during research elective, 2002
    • Appel Research Program in Prostate Cancer, Research Support, 2003 - 2004
    • Director’s Teaching Award for Clinical Science, Johns Hopkins Kimmel Cancer Center, 2005
    • Best Doctors in America, 2006
    • Faculty Teacher of the Year, Brady Urological Institute, 2007
    • Michaele Christian Oncology Development Award, 2011

    Memberships

    • American College of Physicians, 1990 - 1992
      Associate
    • American Association of the Advancement of Science, 1992
    • American College of Physicians, 1992 - 1998
      Member
    • American Association for Cancer Research, 1993 - 1996
      Associate
    • American Society of Clinical Oncology, 1995
    • American Association for Cancer Research, 1996
    • American Urological Association, 1997
      Affiliate Member
    • International Society of Differentiation, 1997
    • American College of Physicians, 1998
      Fellow
    • National Kidney Cancer Foundation, 1999

    Professional Activities

    • Data Safety Monitoring Board, Merck , 2003
      Vioxx in Prostate Cancer
    • Data Safety Monitoring Board, GPC Biotech, 2004 - 2007
      Satraplatin in Prostate Cancer
    • Data Safety Monitoring Committee, Sanofi-Aventis , 2007 - 2011
      VEGF-TRAP in Prostate Cancer
    • Data Safety Monitoring Committee, Internal Investigator Initiated Study, 2008 - 2010
      Advisory committee member
  • Videos & Media +
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