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Michael Anthony Carducci, M.D.

Photo of Dr. Michael Anthony Carducci, M.D.

AEGON Professor of Prostate Cancer Research

Professor of Oncology

Male

Expertise: Bladder Cancer, Clinical Trials, Kidney Cancer, Medical Oncology, Oncology, Pain and Palliative Care - Oncology, Prostate Cancer, Testicular Cancer, Urological Oncology, Urology ...read more

Research Interests: Early phase clinical studies; drug development; epigenetics; bone –targeted therapies

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Locations

Johns Hopkins Sidney Kimmel Comprehensive Cancer Center
Appointment Phone: 410-955-8964

401 N. Broadway
Baltimore, MD 21231 map
Phone: 410-614-3977

Sibley Memorial Hospital
Appointment Phone: 202-660-6500

5255 Loughboro Road, NW
1st Floor
Washington, DC 20016 map
Fax: 202-660-6501

Background

Dr. Michael A. Carducci is a medical oncologist affiliated with Sibley Memorial Hospital. He is the AEGON Professor in Prostate Cancer Research at the Johns Hopkins University School of Medicine, as well as the Associate Cancer Center Director for Clinical Research within the Johns Hopkins Kimmel Cancer Center and the Regional Research Director for the National Capital Region for the Kimmel Cancer Center. Dr. Carducci is board certified in internal medicine and medical oncology.

Dr. Carducci has an expertise in various types of cancer including bladder, kidney, prostate and testicular. He also has an expertise in clinical trials, pain and palliative care for oncology, urological oncology, urology and medical oncology. 

A graduate of Georgetown University, Dr. Carducci received his medical degree with high distinction from Wayne State University School of Medicine. He completed an internal medicine internship, residency and chief residency at the University of Colorado Health Sciences Center. He went on to complete medical oncology and research fellowships at the Johns Hopkins Oncology Center at Johns Hopkins Hospital.

A fellow of the American College of Physicians and a fellow of the American Society of Clinical Oncology, Dr. Carducci has received peer-reviewed funding for his laboratory and clinical research from the National Cancer Institute, Department of Defense, and the Prostate Cancer Foundation.  Mentorship of students, fellows, and junior faculty has been another focus of Dr. Carducci’s career in medicine, receiving numerous teaching awards.  Dr. Carducci received the Michaele Christian Award and Lectureship for Oncology Drug Development at the National Cancer Institute in 2011. He is the Chair of the Genitourinary Oncology Committee of ECOG-ACRIN and an active member of the GU Steering Committee for the NCI.  Dr. Carducci is Co-Chair of the Investigational Drug Steering Committee for the NCI and an Associate Editor for GU Cancers for the Journal of Clinical Oncology.  

A translational researcher, Dr. Carducci directs a small laboratory program focused on bringing small molecules into early phase clinical trials.  Overall, his laboratory and clinical research focus is on the development and evaluation of new therapies for urologic cancers.  Incorporation of pharmacodynamics, novel biomarkers, and targeted imaging has been key elements of many of the trials led by Dr. Carducci.  To complete these studies, Dr. Carducci facilitates and brings together a multidisciplinary team from urologists, radiation oncologists, pathologists, biostatisticians, and medical oncologists. Other areas of interest include palliative and end of life care, survivorship, and use of patient reported outcomes in clinical research and care. 

 

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Titles

  • AEGON Professor of Prostate Cancer Research
  • Co-Director, Prostate Cancer/GU Oncology Program
  • Co-Director, Chemical Therapeutics
  • Professor of Oncology
  • Professor of Urology

Departments / Divisions

Centers & Institutes

Education

Degrees

  • MD, Wayne State University School Of Medicine (1988)

Residencies

  • University of Colorado Denver and Health Sciences / Internal Medicine (1992)

Fellowships

  • Johns Hopkins University School of Medicine / Oncology (1995)

Board Certifications

  • American Board of Internal Medicine / Internal Medicine (1991, 2011)
  • American Board of Internal Medicine / Medical Oncology (1995, 2017)

Research & Publications

Research Summary

Dr. Carducci's research focus is on the development and evaluation of new therapies for genitourinary cancers, specifically prostate and renal cancers. Areas of particular interest are bone-targeted therapies, epigenetic strategies, as well as general early phase drug development leading to first-in-human clinical trials.

Core Facility: SKCCC Clinical Research Office

Clinical Trial Keywords

Phase I, Prostate Cancer, Kidney Cancer

Clinical Trials

A Study Of the Effectiveness Of Pomegranate Pills in Men With Prostate Cancer Before Prostatectomy

Simultaneous Care: Linking Palliation to Clinical Trials

Study of Everolimus Added to Combined Hormonal and Radiation Therapy for High Risk Prostate Cancer

Temsirolimus and Vorinostat in Treating Patients With Metastatic Prostate Cancer

Effects of Two Doses of MPX Capsules on Rising Prostate-specific Antigen Levels in Men Following Initial Therapy for Prostate Cancer

Romidepsin in Treating Patients With Lymphoma, Chronic Lymphocytic Leukemia, or Solid Tumors With Liver Dysfunction

Veliparib, Paclitaxel, and Carboplatin in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery and Liver or Kidney Dysfunction

Entinostat and Aldesleukin in Treating Patients With Metastatic Kidney Cancer

Selected Publications

View all on Pubmed

Carducci MA, Saad F, Abrahamsson P-A, Dearnaley DP, Schulman CC, North SA, Sleep DJ, Isaacson JD, Nelson JB. A phase 3 randomized controlled trial of the efficacy and safety of atrasentan in men with metastatic hormone-refractory prostate cancer. Cancer. 2007; 110: 1959-1966.

Kachhap S, Faith D, Qian D, Shabbeer S, Galloway N, Pili R, Denmeade S, DeMarzo A, Carducci M The N-myc Down Regulated Gene1 (NDRG1) is a Rab4a Effector Involved in Vesicular Recycling of E-cadherin. PLoS One 2007; Sep 5;2 (9): e844.

Sweeney CJ, Chen Y-H, Carducci M, Liu G, Jarrard DF, Eisenberger M, Wong Y-N, Hahn N, Kohli M, Cooney MM, Dreicer R, Vogelzang NJ, Picus J, Shevrin D, Hussain M, Garcia JA, DiPaola RS. Chemohormonal therapy in metastatic hormone-sensitive prostate cancer. NEJM. 2015; 373:737-746. Epub 2015 Aug 5.

Scher HI, Morris MJ, Stadler WM, Higano CS, Basch E, Fizazi K, Antonarakis ES, Beer TM, Carducci MA, Chi KN, Corn PG, de Bono JS, Dreicer R, George DJ, Heath EI, Hussain M, Kelly WK, Liu G, Logothetis CJ, Nanus DM, Stein MN, Rathkopf DE, Slovin SF, Ryan CJ, Sartor O, Small EJ, Smith MR, Sternberg CN, Taplin ME, Wilding G, Nelson P, Schwartz LH, Halabi S, Kantoff PW, Armstrong AJ. Trial design and objectives for castration-resistant prostate cancer: Updated recommendations from the Prostate Cancer Clinical Trials Working Group 3. J Clin Oncol. 201; 34: 1402-1418. Epub 2016 Feb 22.

Sternberg C, Armstrong A, Pili R, Ng S, Huddart R, Agarwal N, Khvorostenko D, Lyulko, Brize A, Vogelzang N, Delva R, Harza M, Thanos A, James N, Werbrouck P, Bogemann M, Hutson T, Milecki P, Cowdhury S, Gallardo E, Schwartsmann G, Pouget J-C, Baton F, Nederman T, Tuvesson H, Carducci M.. Phase III randomized, double-blind, placebo-controlled study of tasquinimod in men with metastatic castration-resistant prostate cancer. J Clin Oncol. 2016 Jun 13. [Epub ahead of print]

Activities & Honors

Honors

  • Michaele Christian Oncology Development Award, 2011
  • Faculty Teacher of the Year, Brady Urological Institute, 2007
  • Best Doctors in America, 2006
  • Director’s Teaching Award for Clinical Science, Johns Hopkins Kimmel Cancer Center, 2005
  • Appel Research Program in Prostate Cancer, Research Support, 2003 - 2004
  • Talma Eykman Foundation Award to Fleur van de Geijn (Dr. Carducci- Mentor) for outstanding research during research elective, 2002
  • Osler Medicine Housestaff Teaching Award, Department of Medicine, The Johns Hopkins University School of Medicine, 1997
  • Second Prize, American Urological Association/CaP CURE Contest, 1996
  • Catherine S. and Isaac Hecht Award for Cancer Research, 1995 - 1997
  • Merit Award Recipient, American Society of Clinical Oncology, 1995
  • Wellcome Oncology Clinical Research Scholar, American Association for Cancer Research, 1995
  • Third Prize, 1995 American Urological Association/CaP CURE Contest,, 1995
  • Young Investigator Award, American Society of Clinical Oncology, 1995
  • Housestaff Teaching Award, Department of Medicine University of Colorado Health Sciences Center, 1991
  • Distinguished Service Award, Wayne State University School of Medicine, 1988
  • M.D. with High Distinction, Wayne State University, 1988
  • Alpha Omega Alpha, 1986
  • Alpha Sigma Nu, Jesuit Honor Society, 1982
  • Salutatorian, Bishop Moore High School, 1979

Memberships

  • American Association for Cancer Research, 1996
  • American Association for Cancer Research, 1993 - 1996
    Associate
  • American Association of the Advancement of Science, 1992
  • American College of Physicians, 1990 - 1992
    Associate
  • American College of Physicians, 1998
    Fellow
  • American College of Physicians, 1992 - 1998
    Member
  • American Society of Clinical Oncology, 1995
  • American Urological Association, 1997
    Affiliate Member
  • International Society of Differentiation, 1997
  • National Kidney Cancer Foundation, 1999

Professional Activities

  • Data Safety Monitoring Board, GPC Biotech, 2004 - 2007
    Satraplatin in Prostate Cancer
  • Data Safety Monitoring Board, Merck , 2003
    Vioxx in Prostate Cancer
  • Data Safety Monitoring Committee, Internal Investigator Initiated Study, 2008 - 2010
    Advisory committee member
  • Data Safety Monitoring Committee, Sanofi-Aventis , 2007 - 2011
    VEGF-TRAP in Prostate Cancer
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