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Michael Anthony Carducci, MD

AEGON Professor of Prostate Cancer Research
Professor of Oncology
Male
Appointment Phone

410-955-8964

Main Location

Johns Hopkins Sidney Kimmel Comprehensive Cancer Center

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Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

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Call +1-410-502-0773 (7a.m. to 6p.m., EST, Mon-Fri)

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Titles

  • AEGON Professor of Prostate Cancer Research
  • Co-Director, Prostate Cancer/GU Oncology Program
  • Co-Director, Chemical Therapeutics
  • Professor of Oncology
  • Professor of Urology

Centers & Institutes

  • James Buchanan Brady Urological Institute
  • Sidney Kimmel Comprehensive Cancer Center

Expertise

Bladder Cancer, Clinical Trials, Kidney Cancer, Medical Oncology, Pain and Palliative Care - Oncology, Prostate Cancer, Testicular Cancer, Urological Oncology, Urology

Research Interests

Development and Evaluation of New Therapies for Urologic Cancers

Biography

Dr. Michael Carducci is a professor of urology and oncology at the Johns Hopkins School of Medicine. He is co-leader of the Prostate Cancer / Genitourinary Oncology Program and co-leader of the Chemical Therapeutics Program at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins.

Dr. Carducci received his undergraduate degree from Georgetown University and his medical degree from Wayne State University School of Medicine. He completed an internal medicine internship, residency and chief residency at the University of Colorado Health Sciences Center. He went on to complete medical oncology and research fellowships at the Johns Hopkins Oncology Center at The Johns Hopkins Hospital.

A translational researcher, Dr. Carducci directs a laboratory program focused on the re-expression of epigenetically silenced genes in cancer cells via the use of small molecules targeting DNA methyltransferases and histone deacetylases, and manages a portfolio of clinical trials targeted at introducing these small molecules into cancer treatment. Overall, his laboratory and clinical research focus is on the development and evaluation of new therapies for urologic cancers.

A fellow of the American College of Physicians, Dr. Carducci is a member of several professional organizations, including the American Association for Cancer Research (AACR), American Society of Clinical Oncology (ASCO) and American Urological Association (AUA). Dr. Carducci serves as the principal investigator for a number of National Cancer Institute-supported clinical trials and leads the Johns Hopkins site for the Department of Defense Prostate Cancer Clinical Trials Consortium grant. In addition, he has received peer-reviewed funding for his laboratory and clinical research from the Department of Defense and the Prostate Cancer Foundation.

He is the chair of the Prostate Cancer Subcommittee of the Genitourinary Oncology Committee of ECOG and serves as an alternate to the GU Steering Committee for the National Cancer Institute. Dr. Carducci is also a full member of the Investigational Drug Steering Committee for the NCI. Within ASCO, he is currently chair of the Scientific Program Committee and has previously served on the Cancer Education, Scientific Program and Grants Selection Committees.

Languages

  • English

Memberships

National Kidney Cancer Foundation, 1999

American College of Physicians, Fellow, 1998

International Society of Differentiation, 1997

American Urological Association, Affiliate Member, 1997

American Association for Cancer Research, 1996

American Society of Clinical Oncology, 1995

American Association for Cancer Research, Associate, 1993-1996

American Association of the Advancement of Science, 1992

American College of Physicians, Member, 1992-1998

American College of Physicians, Associate, 1990-1992

Clinical Trial Keywords

  • Phase I
  • Prostate Cancer
  • Kidney Cancer
Additional Resources +
  • Education +

    Training

    • Wayne State University School of Medicine (Detroit MI) (1988)

    Fellowships

    • Johns Hopkins University School of Medicine / Oncology (Baltimore MD) (1995)
    • Johns Hopkins University School of Medicine / Oncology (Baltimore MD) (1992)

    Certifications

    • American Board of Internal Medicine / Medical Oncology (1995)
    • American Board of Internal Medicine / Internal Medicine (1991)
  • Research & Publications +

    Research Summary

    Dr. Carducci's research focus is on the development and evaluation of new therapies for genitourinary cancers, specifically prostate and renal cancers. Areas of particular interest are bone-targeted therapies, epigenetic strategies, as well as general early phase drug development leading to first-in-human clinical trials.

    Selected Publications

    1. Armstrong AJ, Netto GJ, Rudek MA, Halabi S, Wood DP, Creel PA, Mundy K, Davis SL, Wang T, Albadine R, Schultz L, Partin AW, Jimeno A, Fedor H, Febbo PG, George DJ, Gurganus R, De Marzo AM, Carducci MA. “A pharmacodynamic study of rapamycin in men with intermediate- to high-risk localized prostate cancer.” Clin Cancer Res. 2010 Jun 1;16(11):3057-3066.
    2. Cetin K, Beebe-Dimmer JL, Fryzek JP, Markus RE, Carducci MA. “Recent time trends in the epidemiology of stage IV prostate cancer in the United States: analysis of data from the Surveillance, Epidemiology, and End Results Program.” Urology. 2010 Jun;75(6):1396-1404.
    3. DiPaola RS, Chen YH, Stein M, Vaughn D, Patrick-Miller L, Carducci M, Roth B, White E, Wilding G. “A randomized phase II trial of mitoxantrone, estramustine and vinorelbine or bcl-2 modulation with 13-cis retinoic acid, interferon and paclitaxel in patients with metastatic castrate-resistant prostate cancer: ECOG 3899.” J Transl Med. 2010;8:20.
    4. Franke RM, Carducci MA, Rudek MA, Baker SD, Sparreboom A. “Castration-dependent pharmacokinetics of docetaxel in patients with prostate cancer.” J Clin Oncol. 2010 Oct 20;28(30):4562-4567.
    5. Kachhap SK, Rosmus N, Collis SJ, Kortenhorst MS, Wissing MD, Hedayati M, Shabbeer S, Mendonca J, Deangelis J, Marchionni L, Lin J, Hoti N, Nortier JW, DeWeese TL, Hammers H, Carducci, MA. “Downregulation of homologous recombination DNA repair genes by HDAC inhibition in prostate cancer is mediated through the E2F1 transcription factor.” PLoS One. 2010;5(6):e11208.

    Clinical Trials

    A Study Of the Effectiveness Of Pomegranate Pills in Men With Prostate Cancer Before Prostatectomy

    Simultaneous Care: Linking Palliation to Clinical Trials

    Study of Everolimus Added to Combined Hormonal and Radiation Therapy for High Risk Prostate Cancer

    Temsirolimus and Vorinostat in Treating Patients With Metastatic Prostate Cancer

    Effects of Two Doses of MPX Capsules on Rising Prostate-specific Antigen Levels in Men Following Initial Therapy for Prostate Cancer

    Romidepsin in Treating Patients With Lymphoma, Chronic Lymphocytic Leukemia, or Solid Tumors With Liver Dysfunction

    Veliparib, Paclitaxel, and Carboplatin in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery and Liver or Kidney Dysfunction

    Entinostat and Aldesleukin in Treating Patients With Metastatic Kidney Cancer

  • Academic Affiliations & Courses +
  • Activities & Honors +

    Honors

    Michaele Christian Oncology Development Award, 2011

    Brady Urological Institute, Faculty Teacher of the Year, 2007

    Best Doctors in America, 2006

    Director’s Teaching Award for Clinical Science, Johns Hopkins Kimmel Cancer Center, 2005

    Appel Research Program in Prostate Cancer, Research Support 2003-2004

    Talma Eykman Foundation Award to Fleur van de Geijn (Dr. Carducci- Mentor) for outstanding research during research elective, 2002

    Osler Medicine Housestaff Teaching Award, Department of Medicine, The Johns Hopkins University School of Medicine, 1997

    Second Prize, 1996 American Urological Association/CaP CURE Contest

    Catherine S. and Isaac Hecht Award for Cancer Research, 1995-1997

    Merit Award Recipient, American Society of Clinical Oncology, 1995

    Wellcome Oncology Clinical Research Scholar American Association for Cancer Research, 1995

    Third Prize, 1995 American Urological Association/CaP CURE Contest, 1995

    Young Investigator Award, American Society of Clinical Oncology, 1995

    Housestaff Teaching Award Department of Medicine University of Colorado Health Sciences Center, 1991

    Distinguished Service Award, Wayne State University School of Medicine, 1988

    M.D. with High Distinction, Wayne State University, 1988

    Alpha Omega Alpha, 1986

    Alpha Sigma Nu - Jesuit Honor Society, 1982

    Salutatorian, Bishop Moore High School, 1979

    Professional Activities

    Data Safety Monitoring Committee, Internal Investigator Initiated Study (C-Novyi in Solid Tumors- L. Diaz, PI), Advisory committee member, 2008-2010

    Data Safety Monitoring Committee, Sanofi-Aventis (VEGF-TRAP in Prostate Cancer), 2007-2011

    Data Safety Monitoring Board, GPC Biotech (Satraplatin in Prostate Cancer), 2004-2007

    Panel Member, Molecular Targets and Drug Development Working Group, National Cancer Institute Advisory Committee to SPORE Program, 2005

    Data Safety Monitoring Board, Merck , Inc (Vioxx in Prostate Cancer), 2003

    Member, Subcommittee on Renal Cell/Testicular Cancer, National Cancer Center Network, 2001

    Member, External Advisory Panel to Genitourinary Oncology Research Program, University of Chicago Cancer Center, 2000

    Member, Advisory Committee for Johns Hopkins Early Diagnosis Research Network – EDRN Clinical Tumor Marker Testing Center (Chair – Alan Partin, M.D., Ph.D.), 1999

    Member, Subcommittee on Palliative Care, National Cancer Center Network, 1999

    Member, Task Force on Supportive Care, National Cancer Center Network, 1999

  • Videos & Media +
  • Events +
  • Contact & Locations +

    Locations

    Johns Hopkins Sidney Kimmel Comprehensive Cancer Center
    401 N. Broadway
    Baltimore, MD 21231
    Phone: 410-614-3977
    Appointment Phone: 410-955-8964
    Location Map
    Sibley Memorial Hospital
    5255 Loughboro Road NW
    Washington, DC 20016
    Appointment Phone: 202-660-6500
    Location Map

    Department/Division

    • Oncology

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