Dr. Horton has extensive research in pulmonary fibrosis, both in preclinical models and in human trials. Her lab has been able to help rapidly develop novel, genetic, tissue-specific models of immune dysfunction that were important in defining the immune regulation of fibrosis as well as to develop and test strategies to arrest and treat these diseases. She has utilized immunotherapy, in the form of T cell skewing, to prevent and reverse chemical-induced lung fibrosis.
She is co-director of the Johns Hopkins Interstitial Lung Disease Clinic and served as primary investigator on clinical trials for idiopathic pulmonary fibrosis (IPF), which led to the discovery of one of the first treatments shown to improve quality of life in IPF. She is also site investigator for several past and present pharmacologic trials for IPF, including the hallmark ASCEND trial leading to the recent FDA approval of the first drug, pirfenidone, to slow down the progression of IPF.
Hillel AT, Samad I, Ma G, Ding D, Sadtler K, Powell JD, Lane AP, Horton MR. "Dysregulated macrophages are present in bleomycin-induced murine laryngotracheal stenosis." Otolaryngol Head Neck Surg. 2015 Aug;153(2):244-50.
Namba DR, Ma G, Samad I, Ding D, Pandian V, Powell JD, Horton MR, Hillel AT. "Rapamycin inhibits human laryngotracheal stenosis-derived fibroblast proliferation, metabolism, and function in vitro." Otolaryngol Head Neck Surg. 2015 May;152(5):881-8.
Leone RD, Horton MR, Powell JD. "Something in the air: hyperoxic conditioning of the tumor microenvironment for enhanced immunotherapy." Cancer Cell. 2015 Apr 13;27(4):435-6.
Limjunyawong N, Fallica J, Horton MR, Mitzner W. "Measurement of the pressure-volume curve in mouse lungs." J Vis Exp. 2015 Jan 27;(95):52376.
Hillel AT, Namba D, Ding D, Pandian V, Elisseeff JH, Horton MR. "An in situ, in vivo murine model for the study of laryngotracheal stenosis." JAMA Otolaryngol Head Neck Surg. 2014 Oct;140(10):961-6.
Hamblin MJ, Eberlein M, Black K, Hallowell R, Collins S, Chan-Li Y, Horton MR. "Lovastatin inhibits low molecular weight hyaluronan induced chemokine expression via LFA-1 and decreases bleomycin-induced pulmonary fibrosis." Int J Biomed Sci. 2014 Sep;10(3):146-57.
Aggarwal NR, Tsushima K, Eto Y, Tripathi A, Mandke P, Mock JR, Garibaldi BT, Singer BD, Sidhaye VK, Horton MR, King LS, D'Alessio FR. "Immunological priming requires regulatory T cells and IL-10-producing macrophages to accelerate resolution from severe lung inflammation." J Immunol. 2014 May 1;192(9):4453-64.
Heikamp EB, Patel CH, Collins S, Waickman A, Oh MH, Sun IH, Illei P, Sharma A, Naray-Fejes-Toth A, Fejes-Toth G, Misra-Sen J, Horton MR, Powell JD. "The AGC kinase SGK1 regulates TH1 and TH2 differentiation downstream of the mTORC2 complex." Nat Immunol. 2014 May;15(5):457-64. doi: 10.1038/ni.2867. Epub 2014 Apr 6.
Zhao H, Chan-Li Y, Collins SL, Zhang Y, Hallowell RW, Mitzner W, Horton MR. "Pulmonary delivery of docosahexaenoic acid mitigates bleomycin-induced pulmonary fibrosis." BMC Pulm Med. 2014 Apr 18;14:64. doi: 10.1186/1471-2466-14-64.
Limjunyawong N, Mitzner W, Horton MR. "A mouse model of chronic idiopathic pulmonary fibrosis." Physiol Rep. 2014 Feb 25;2(2):e00249.
Sussan TE, Ingole V, Kim JH, McCormick S, Negherbon J, Fallica J, Akulian J, Yarmus L, Feller-Kopman D, Wills-Karp M, Horton MR, Breysse PN, Agrawal A, Juvekar S, Salvi S, Biswal S. Source of Biomass Cooking Fuel Determines Pulmonary Response to Household Air Pollution. Am J Respir Cell Mol Biol. 2013 Oct 8. [Epub ahead of print] PMID: 24102120
Lechtzin N, Hilliard ME, Horton MR. Validation of the Cough Quality-of-Life Questionnaire in patients with idiopathic pulmonary fibrosis. Chest. 2013 Jun;143(6):1745-9. doi: 10.1378/chest.12-2870. PMID: 23519393
Black KE, Collins SL, Hagan RS, Hamblin MJ, Chan-Li Y, Hallowell RW, Powell JD, Horton MR. Hyaluronan fragments induce IFNβ via a novel TLR4-TRIF-TBK1-IRF3-dependent pathway. J Inflamm (Lond). 2013 May 30;10(1):23. doi: 10.1186/1476-9255-10-23. PMID: 23721397
Lechtzin N, Horton MR. Author reply: To PMID 22986377. Ann Intern Med. 2013 Mar 19;158(6):498-9. doi: 10.7326/0003-4819-158-6-201303190-00016. No abstract available. PMID: 23553005
Collins S, Waickman A, Basson A, Kupfer A, Licht JD, Horton MR, Powell JD. Regulation of CD4⁺ and CD8⁺ effector responses by Sprouty-1. PLoS One. 2012;7(11):e49801. doi: 10.1371/journal.pone.0049801. Epub 2012 Nov 15. PMID: 23166773
Horton MR, Hallowell RW. Revisiting thalidomide: fighting with caution against idiopathic pulmonary fibrosis. Drugs Today (Barc). 2012 Oct;48(10):661-71. doi: 10.1358/dot.2012.48.10.1855760. Review. PMID: 23110262
Horton MR, Santopietro V, Mathew L, Horton KM, Polito AJ, Liu MC, Danoff SK, Lechtzin N. Thalidomide for the treatment of cough in idiopathic pulmonary fibrosis: a randomized trial. Ann Intern Med. 2012 Sep 18;157(6):398-406. doi: 10.7326/0003-4819-157-6-201209180-00003. PMID: 22986377
Hallowell RW, Reed RM, Fraig M, Horton MR, Girgis RE. Severe pulmonary hypertension in idiopathic nonspecific interstitial pneumonia. Pulm Circ. 2012 Jan-Mar;2(1):101-6. doi: 10.4103/2045-8932.94842. PMID: 22558525
Collins SL, Chan-Li Y, Hallowell RW, Powell JD, Horton MR. Pulmonary vaccination as a novel treatment for lung fibrosis. PLoS One. 2012;7(2):e31299. doi: 10.1371/journal.pone.0031299. Epub 2012 Feb 17. PMID: 22363610
Powell JD, Pollizzi KN, Heikamp EB, Horton MR. Regulation of immune responses by mTOR. Annu Rev Immunol. 2012;30:39-68. doi: 10.1146/annurev-immunol-020711-075024. Epub 2011 Nov 29. Review. PMID: 22136167