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Kenneth Jay Cohen, M.D.

Photo of Dr. Kenneth Jay Cohen, M.D.

Clinical Director Pediatric Oncology

Associate Professor of Oncology

Male

Expertise: Pediatric Brain Cancer, Pediatric Brain Tumors, Pediatric Neuro-Oncology, Pediatric Oncology, Pediatric Spinal Cord Tumors

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443-287-6997
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410-464-6641
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+1-410-502-7683
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Locations

The Johns Hopkins Hospital (Main Entrance)
Appointment Phone: 443-287-6997

1800 Orleans St.
Bloomberg Children's Center
Baltimore, MD 21287 map
Fax: 410-955-0028

Background

Dr. Cohen is Director of Pediatric Neuro-Oncology and Clinical Director of the Division of Pediatric Oncology at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. He received his undergraduate degree at Brown University and earned his MD at the Upstate Medical University, in Syracuse, NY. He did his general Pediatric Residency and Chief Residency at the University of Colorado, and completed his Pediatric Hematology/Oncology Fellowship at Johns Hopkins. He has served on the faculty since 1994. Dr. Cohen is co-chair of the High-Grade Glioma committee for the Children's Oncology Group and in that capacity has a particular research interest in the development of therapeutics for the treatment of infiltrating gliomas. He is Chief Medical Officer and head of the Scientific Advisory Board for Solving Kids Cancer. He is a Scientific Advisor for the Childhood Brain Tumor Foundation.

The Pediatric Neuro-Oncology program conducts a broad range of research centered primarily around the development and testing of novel therapeutics for children with brain tumors. Included in this research has been the use of low-dose, long-exposure treatment strategies as well as the selective use of high-dose treatment regimens. The multidisciplinary nature of this work translates into continual collaboration with specialists in pediatric neurosurgery, radiation oncology, neuropathology, neuroradiology, neurology, neuro-ophthalmology, and other related disciplines. Research is also coordinated with the Neuropsychology group at the Kennedy-Krieger Institute.

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Titles

  • Clinical Director Pediatric Oncology
  • Director, Pediatric Neuro-Oncology
  • Associate Professor of Oncology
  • Associate Professor of Pediatrics

Departments / Divisions

Education

Degrees

  • , SUNY Upstate Medical University (1987)

Board Certifications

  • American Board of Pediatrics / Pediatric Hematology-Oncology (1994)

Research & Publications

Research Summary

More children die of brain tumors than of any other type of pediatric cancer. Significant advances have been made in surgical and supportive care, but with fewer evident therapeutic benefits. A variety of new therapies are being studied in the hope of finding new treatments that are more effective, yet less toxic to the developing brain. One promising new avenue is research that links neuropathology with neurosurgical sciences.

Clinical Trial Keywords

Pediatric brain tumors, Neuro-Oncology

Selected Publications

Journal Citations
Pollack IF, Hamilton RL, Burger PC, Brat DJ, Rosenblum MK, Murdoch GH, Nikiforova MN, Holmes EJ, Zhou T, Cohen KJ, Jakacki RI; Children's Oncology Group. Akt activation is a common event in pediatric malignant gliomas and a potential adverse prognostic marker: a report from the Children's Oncology Group. J Neurooncol. 2010 Sep;99(2):155-63.

Johnson MW, Eberhart CG, Perry A, Tihan T, Cohen KJ, Rosenblum MK, Rais-Bahrami S, Goldthwaite P, Burger PC. Spectrum of pilomyxoid astrocytomas: intermediate pilomyxoid tumors. Am J Surg Pathol. 2010 Dec:34(12):1783-91.

Cohen KJ, Pollack IF, Zhou T, Buxton A, Holmes EJ, Burger PC, Brat DJ, Rosenblum MK, Hamilton RL, Lavey RS, Heideman RL. Temozolomide in the treatment of high-grade gliomas in children; a report from the Children's Oncology Group. Neuro Oncol. 2011 Mar;13(3):317-23.

Cohen KJ, Heideman RL, Zhou T, Holmes EJ, Lavey RS, Bouffet E, Pollack IF. Temozolomide in the treatment of children with newly diagnosed diffuse intrinsic pontine gliomas: A report from the Children's Oncology Group. Neuro Oncol. 2011 Apr;13(4):410-6.

Rattenberry W, McDonough CH, Cohen KJ. Medulloblastoma with myogenic differentiation; long-term survival in a patient treated with aggressive combination therapy and autologous stem cell transplantation. J Neurooncol, 2011 Dec; 105(3):659-62.

Deib G, Poretti A, Meoded A, Cohen KJ, Raymond GV, Huisman TAGM. Onset of adreno-leukodystrophy after medulloblastoma therapy: causal connection or coincidence? J of Inherit Metab Dis,2012;2:29-32.

Raabe EH, Lim KS, Kim JM, Meeker A, Mao XG, Nikkhah G, Maciaczyk J, Kahlert U, Jain D, Bar E, Cohen KJ, Eberhart CG. BRAF Activation induces transformation and then senescence in human neural stem cells: A pilocytic astrocytoma model. Clin Cancer Res. 2011 Jun 1;17(11):3590-9.

Pinto PS, Huisman TAGM, Ahn E, Jordan LC, Burger P, Cohen KJ, Patay Z, Tekes A. Magnetic resonance imaging features of pediatric meningiomas: A retrospective analysis. J Neuroradiol. 2012 Oct; 39(4):218-26.

Levine, D, Cohen KJ, Wendler D. Shared Medical Decision-Making: Considering what Options to Present based on an Ethical Analysis of the Treatment of Brain Tumors in Very Young Children. 2012, Pediatr Blood Cancer, Aug;59(2):216-20.

Gajjar A, Packer RJ, Foreman NK, Cohen K, Haas-Kogan D, Merchant TE; on behalf of the COG Brain Tumor Committee. Children's Oncology Group's 2013 blueprint for research: Central nervous system tumors. Pediatr Blood Cancer. 2013 (60); 1022-1026.

Lam CG, Roter DL, Cohen KJ. Survey of quality, readability, and social reach of websites on osteosarcoma in adolescents. Patient Educ Couns. 2013 Jan;90(1):82-7.

Rodriguez FJ, Perry A, Rosenblum MK, Krawitz S, Cohen KJ, Lin D, Mosier S, Lin MT, Eberhart CG, Burger PC. Disseminated oligodendroglial-like leptomeningeal tumor of childhood: a distinctive clinicopathologic entity. Acta Neuropathol. 2012 Nov;124(5):627-41.

Redmond KJ, Mahone EM, Terezakis S, Ishaq O, Ford E, McNutt T, Kleinberg L, Cohen KJ, Wharam M, Horska A. Association between radiation dose to neuronal progenitor cell niches and temporal lobes and performance on neuropsychological testing in children: a prospective study. Neuro Oncol. 2013 Mar;15(3):360-9.

Guss ZD, Moningi S, Jallo GI, Cohen KJ, Wharam MD, Terezakis SA. Management of pediatric spinal cord astrocytomas: outcomes with adjuvant radiation. Int J Radiat Oncol Biol Phys. 2013 Apr 1;85(5):1307-11.

Cohen KJ, Gibbs IC, Fisher PG, Hayashi RJ, Macy ME, Gore L. A phase I trial of arsenic trioxide chemoradiotherapy for infiltrating astrocytomas of childhood. Neuro Oncol. 2013 Jun;15(6):783-87.

Yohay K, Wolf DS, Aronson LJ, Duus M, Melhem ER, Cohen KJ. Vascular distribution of glioblastoma multiforme at diagnosis. Interv Neuroradiol. 2013 Mar;19(1):127-31.

Wolf DS, Cohen KJ. Is low and slow the way to go? Metronomic therapy in the treatment of pediatric brain tumors. CNS Oncol. 2013 May;2(3):211-3.

Raabe E, Kieran MW, Cohen KJ. New strategies in pediatric gliomas: molecular advances in pediatric low-grade gliomas as a model. Clin Cancer Res. 2013 Sep 1;19(17):4553-8.

Noje C, Cohen KJ, Jordan LC. Hemorrhagic and ischemic stroke in children with cancer. Pediatric Neurol. 2013 (Oct;49(4):237-42.

Poretti A, Meoded A, Cohen KJ, Grotzer MA, Boltshauser E, Huisman TA. Apparent diffusion coefficient of pediatric cerebellar tumors: a biomarker of tumor grade? Pediatr Blood Cancer. 2013 Dec;60(12):2036-41.

Gajjar A, Packer RJ, Foreman NK, Cohen K, et al. Children's Oncology Group's 2013 Blueprint for Research: Central Nervous Systems. Pediatr Blood Cancer. 2013;60:1022-1026.

Fontebasso AM, Papillon-Cavanagh S,…Cohen K, et al. Recurrent somatic mutations in ACVR1 in pediatric midline high-grade astrocytoma. Nature Genetics, 2014 May;46(5):462-6.

Karajannis MA, Legault G, Fisher MJ, Milla SS, Cohen KJ, et al. Phase II study of sorafenib in children with recurrent or progressive low-grade astrocytomas. Neuro Oncol, 2014 Oct;16(10):1408-16.

Martin AM, Raabe E, Eberhart C, Cohen KJ. Management of pediatric and adult patients with medulloblastoma. Curr Treat Options Oncol. 2014 Dec;15(4);581-94.

Activities & Honors

Honors

  • Chief Scientific Officer, Solving Kids' Cancer Scientific Advisory Board, 2011

Memberships

  • American Society of Clinical Oncology, 1994
  • American Society of Pediatric Hematology/Oncology, 1997
  • Society for Neuro-Oncology, 1999
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