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Kenneth Jay Cohen, M.D.
Clinical Director Pediatric Oncology
Professor of Oncology
Expertise: Pediatric Brain Cancer, Pediatric Brain Tumors, Pediatric Neuro-Oncology, Pediatric Oncology, Pediatric Spinal Cord Tumors, Von Hippel-Lindau (VHL) ...read more
Research Interests: Small-molecule and biological regulatory mechanisms; Control of DNA replication and chromosome superstructure; Structural and catalytic mechanisms of nucleic-acid machines and assemblies ...read more
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The Johns Hopkins Hospital (Main Entrance)
Appointment Phone: 410-955-8751
1800 Orleans St.
The Charlotte R. Bloomberg Children's Center Building, 11th Floor
Baltimore, MD 21287 map
Dr. Cohen is Director of Pediatric Neuro-Oncology and Clinical Director of the Division of Pediatric Oncology at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. He received his undergraduate degree at Brown University and earned his MD at the Upstate Medical University, in Syracuse, NY. He did his general Pediatric Residency and Chief Residency at the University of Colorado, and completed his Pediatric Hematology/Oncology Fellowship at Johns Hopkins. He has served on the faculty since 1994. Dr. Cohen is co-chair of the High-Grade Glioma committee for the Children's Oncology Group and in that capacity has a particular research interest in the development of therapeutics for the treatment of infiltrating gliomas. He is Chief Medical Officer and head of the Scientific Advisory Board for Solving Kids Cancer. He is a Scientific Advisor for the Childhood Brain Tumor Foundation.
The Pediatric Neuro-Oncology program conducts a broad range of research centered primarily around the development and testing of novel therapeutics for children with brain tumors. Included in this research has been the use of low-dose, long-exposure treatment strategies as well as the selective use of high-dose treatment regimens. The multidisciplinary nature of this work translates into continual collaboration with specialists in pediatric neurosurgery, radiation oncology, neuropathology, neuroradiology, neurology, neuro-ophthalmology, and other related disciplines. Research is also coordinated with the Neuropsychology group at the Kennedy-Krieger Institute.
- Clinical Director Pediatric Oncology
- Director, Pediatric Neuro-Oncology
- Professor of Oncology
- Professor of Pediatrics
- SUNY Upstate Medical University (1987)
- American Board of Pediatrics / Pediatric Hematology-Oncology (1994)
Research & Publications
More children die of brain tumors than of any other type of pediatric cancer. Significant advances have been made in surgical and supportive care, but with fewer evident therapeutic benefits. A variety of new therapies are being studied in the hope of finding new treatments that are more effective, yet less toxic to the developing brain. One promising new avenue is research that links neuropathology with neurosurgical sciences.
Clinical Trial KeywordsPediatric brain tumors, Neuro-Oncology
Cohen KJ, Pollack IF, Zhou T, Buxton A, Holmes EJ, Burger PC, Brat DJ, Rosenblum MK, Hamilton RL, Lavey RS, Heideman RL. Temozolomide in the treatment of high-grade gliomas in children; a report from the Children's Oncology Group. Neuro Oncol. 2011 Mar;13(3):317-23
Cohen KJ, Heideman RL, Zhou T, Holmes EJ, Lavey RS, Bouffet E, Pollack IF. Temozolomide in the treatment of children with newly diagnosed diffuse intrinsic pontine gliomas: A report from the Children's Oncology Group. Neuro Oncol. 2011 Apr;13(4):410-6
Cohen KJ, Gibbs IC, Fisher PG, Hayashi RJ, Macy ME, Gore L. A phase I trial of arsenic trioxide chemoradiotherapy for infiltrating astrocytomas of childhood. Neuro Oncol. 2013 Mar 3.
Wolf DS, Cohen KJ. Is low and slow the way to go? Metronomic therapy in the treatment of pediatric brain tumors. CNS Oncol. 2013 May;2(3):211-3.
Martin AM, Raabe E, Eberhart C, Cohen KJ. Management of pediatric and adult patients with medulloblastoma. Curr Treat Options Oncol. 2014 Dec;15(4);581-94
Activities & Honors
- Chief Scientific Officer, Solving Kids' Cancer Scientific Advisory Board, 2011
- American Society of Clinical Oncology, 1994
- American Society of Pediatric Hematology/Oncology, 1997
- Society for Neuro-Oncology, 1999