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Kenneth Jay Cohen, M.D.

Director, Pediatric Neuro-Oncology
Associate Professor of Oncology


Appointment Phone


Main Location

The Johns Hopkins Hospital

Out-of-State & International Patients +
Out of State Patients

Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

Learn more about our out-of-state patient services »

International Patients

Call +1-410-502-7683 (7a.m. to 6p.m., EST, Mon-Fri)

Learn more about our international patient services »


  • Director, Pediatric Neuro-Oncology
  • Clinical Director Pediatric Oncology
  • Associate Professor
  • Associate Professor of Oncology
  • Associate Professor of Pediatrics

Centers & Institutes


  • Oncology - Gastroenterology and Hepatology
  • Oncology - Pediatric Oncology
  • Pediatrics


The Johns Hopkins Hospital

Appointment Phone: 443-287-6997

600 N. Wolfe Street
Charlotte R. Bloomberg Childrens Center
Baltimore, MD 21287 map
Fax: 410-955-0028


Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, Aplastic Anemia, General Pediatrics, Hematologic Malignancies, Hodgkin's Disease , Leukemia, Leukemia/Lymphoma, Medical Oncology, Non-Hodgkin's Lymphoma, Pediatric Brain Cancer, Pediatric Brain Tumors, Pediatric Lymphomas, Pediatric Neuro-Oncology, Pediatric Oncology, Pediatric Spinal Cord Tumors

Research Interests

More children die of brain tumors than any other form of pediatric cancer. Significant advances have been made in surgical and supportive care, but with less evident benefits in therapy. A variety of novel therapeutic agents and approaches are being studied in the hope of finding new approaches to treatment that are efficacious and ideally less toxic to the developing brain. The development of novel therapeutics is being driven by a growing translational initiative in cooperation with the neuropathology and neurosurgical sciences group.


Dr. Cohen is the Director of Pediatric Neuro-Oncology and the Clinical Director in the Division of Pediatric Oncology at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. He received his undergraduate degree at Brown University, completed medical school at the Upstate Medical University in Syracuse, NY. He did his general Pediatric Residency and Chief Residency at the University of Colorado. He completed his Pediatric Hematology/Oncology Fellowship at Johns Hopkins and has been a member of the faculty since 1994. Dr. Cohen is the co-chair of the High-Grade Glioma committee for the Childrens Oncology Group and in that capacity has a particular research interest in the development of therapeutics for the treatment of infiltrating gliomas. He is the Chief Medical Officer and head of the Scientific Advisory Board for Solving Kids Cancer. He is a Scientific Advisor for the Childhood Brain Tumor Foundation.
The Pediatric Neuro-Oncology program provides a wide-range of research. Clinically, a major focus of the program is the development and testing of novel therapeutics for children with brain tumors. Included in this research has been the use of low-dose, long exposure treatment strategies as well as the selective use of high-dose regimens in the treatment of these children. Recognizing the multidisciplinary nature of this work, there is constant collaboration with specialists in pediatric neurosurgery, radiation oncology, neuropathology, neuroradiology, neurology, neuro-ophthalmology and other supporting disciplines. Research is also coordinated with the Neuropsychology group at the Kennedy-Krieger Institute. more

    Additional Information

  • Education +


    • SUNY Upstate Medical University (1987)


    • American Board of Pediatrics / Pediatric Hematology-Oncology (1994, 2009)
  • Research & Publications +

    Clinical Trial Keywords: Pediatric brain tumors, medulloblastoma Pediatric Lymphomas and Neuro-Oncology

    Selected Publications

    Journal Citations
    Chi SN, Zimmerman MA, Yao X, Fletcher W, Cohen KJ, Burger PC et. al. Intensive Multi-Modality Treatment for Children with Newly Diagnosed Central Nervous System Atypical Teratoid Rhabdoid Tumor. J of Clin Onc, 2009 Jan 20;27(3):385-9.

    Frazier JL, Lee J, Thomale UW, Noggle JC, Cohen KJ, Jallo GI. Treatment of diffuse intrinsic brainstem gliomas: failed approaches and future strategies. J Neurosurg Pediatr. 2009 Apr;3(4): 259-89

    Cohen KJ. Challenges in the management of pediatric malignant gliomas. Neuro-Oncology, 2009 Dec, SP-15.

    Massimino M, Cohen KJ, Finlay JL.Is there a role for myeloablative chemotherapy with autologous hematopoietic cell rescue in the management of childhood high-grade astrocytomas? Pediatr Blood Cancer. 2010 Apr;54(4):641-3.

    Pollack IF, Hamilton RL, Sobol RW, Nikiforova MN, Nikiforov YE, Lyons-Weiler MA, Laframboise WA, Burger PC, Brat DJ, Rosenblum MK, Gilles FH, Yates AJ, Zhou T, Cohen KJ, Finlay JL, Jakacki RI; for the Children's Oncology Group. Mismatch repair deficiency is an uncommon mechanism of alkylator resistance in pediatric malignant gliomas: A report from the children's oncology group. Pediatr Blood Cancer. 2010 Jun 29. [Epub ahead of print]

    Hales RK, Shokek O, Burger PC, Paynter NP, Chaichana KL, Quiones-Hinojosa A, Jallo GI, Cohen KJ, Song DY, Carson BS, Wharam MD. Prognostic factors in pediatric high-grade astrocytoma: the importance of accurate pathologic diagnosis. J Neurooncol. 2010 Aug;99(1):65-71

    Horsk A, Laclair A, Mohamed M, Wells CT, McNutt T, Cohen KJ, Wharam M, Mahone EM, Kates W. Low cerebellar vermis volumes and impaired neuropsychologic performance in children treated for brain tumors and leukemia.AJNR Am J Neuroradiol. 2010 Sep;31(8):1430-7.

    Pollack IF, Hamilton RL, Burger PC, Brat DJ, Rosenblum MK, Murdoch GH, Nikiforova MN, Holmes EJ, Zhou T, Cohen KJ, Jakacki RI; Children's Oncology Group.Akt activation is a common event in pediatric malignant gliomas and a potential adverse prognostic marker: a report from the Children's Oncology Group.J Neurooncol. 2010 Sep;99(2):155-63.

    Cohen KJ, Pollack IF, Zhou T, Buxton A, Holmes EJ, Burger PC, Brat DJ, Rosenblum MK, Hamilton RL, Lavey RS, Heideman RL. Temozolomide in the treatment of high-grade gliomas in children; a report from the Childrens Oncology Group. Neuro-Oncology, in press.
  • Academic Affiliations & Courses +
  • Activities & Honors +


    • Chief Medical Officer, Solving Kids Cancer Scientific Advisory Board


    • ASCO
    • ASPH/O
    • SNO
  • Videos & Media +
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