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Photo of Dr. Cornelia Trimble

Cornelia Liu Trimble, M.D.

Professor of Gynecology and Obstetrics

Female

Appointment Phone

443-997-0400

Main Location

Johns Hopkins Outpatient Center

Out-of-State & International Patients +
Out of State Patients

Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

Learn more about our out-of-state patient services »

International Patients

Call +1-410-502-7683 (7a.m. to 6p.m., EST, Mon-Fri)

Learn more about our international patient services »

Titles

  • Professor of Gynecology and Obstetrics
  • Professor of Oncology
  • Professor of Pathology

Centers & Institutes

Departments

Locations

Johns Hopkins Outpatient Center

Appointment Phone: 443-997-0400

601 N. Caroline Street
Baltimore, MD 21287 map

Johns Hopkins Medicine - Green Spring Station

Appointment Phone: 443-997-0400

10755 Falls Road
Pavilion I
Lutherville, MD 21093 map

Expertise

Cervical Cancer, Cervical Dysplasia, Gynecology and Obstetrics, Human Papillomavirus Infections

Research Interests

Cervical Cancer; HPV; Cancer Vaccines; tumor immunology, tumor microenvironment, intraepithelial neoplasia

    Additional Information

  • Education +

    Degrees

    • Vanderbilt University School of Medicine / MD; Medicine (1988)

    Residencies

    • New York Hospital / Pathology (1991)
    • Johns Hopkins University School of Medicine / Obstetrics and Gynecology (1997)

    Fellowships

    • Johns Hopkins University School of Medicine (1997)

    Certifications

    • American Board of Obstetrics and Gynecology / Obstetrics And Gynecology (2001, 2014)
    • American Board of Pathology / Anatomic Pathology (1993)

    Additional Training

    • Anatomic Pathology
    • Obstetrics and Gynecology
  • Research & Publications +

    Technology Expertise: Human papillomavirus (HPV), cervical dysplasia, clinical trials, CIN2/3, immunotherapy, alternative treatments for HPV disease

    Lab Website: Cervical Dysplasia Research Lab

    Clinical Trials:

    J0866 - A Pilot Study of pNGVL4a-CRT/E7(detox) for the treatment of patients with HPV16+ Cervical Intraepithelial Neoplasia 2/3 (CIN2/3)

    J1498 - A Phase I Study of Intravaginally Administered Artesunate In Women with High Grade Cervical Intraepithelial Neoplasia (CIN2/3)

    J0656 - A Phase I efficacy and safety study of HPV16-specific therapeutic DNA-Vaccinia vaccination in combination with topical imiquimod, in patients with HPV16 high grade cervical dysplasia (CIN2/3)


    Clinical Trial Keywords: therapeutic vaccines, HPV, high grade dysplasia, precancerous, alternative HPV treatments, lesion microenvironment

    Selected Publications

    Peng, S.; Tomson, T.T.; Trimble, C.; He, L.; Hung, C.F.; Wu, T.C. A combination of DNA vaccines targeting human papillomavirus type 16 E6 and E7 generates potent antitumor effects. Gene Ther. 2006 Feb;13(3):257-265.

    Peng, S.; Trimble, C.; He, L.; Tsai, Y.C.; Lin, C.T.; Boyd, D.A.; Pardoll, D.; Hung, C.F.; Wu, T.C. Characterization of HLA-A2-restricted HPV-16 E7-specific CD8(+) T-cell immune responses induced by DNA vaccines in HLA-A2 transgenic mice. Gene Ther. 2006 Jan;13(1):67-77.

    Peng, S.; Trimble, C.; Wu, L.; Pardoll, D.; Roden, R.; Hung, C.F.; Wu, T.C. HLA-DQB1*02-restricted HPV-16 E7 peptide-specific CD4+ T-cell immune responses correlate with regression of HPV-16-associated high-grade squamous intraepithelial lesions. Clin Cancer Res. 2007 Apr 15;13(8):2479-2487.

    Partridge, E.E.; Abu-Rustum, N.; Campos, S.; Fahey, P.J.; Greer, B.E.; Lele, S.M.; Lieberman, R.W.; Lipscomb, G.H.; Morgan, M.; Nava, M.E.; Reynolds, R.K.; Singh, D.K.; Smith-McCune, K.; Teng, N.; Trimble, C.L.; Valea, F.; Wilczynski, S.; National Comprehensive Cancer, N. Cervical cancer screening. J Natl Compr Canc Netw. 2008 Jan;6(1):58-82.

    Peng, S.; Trimble, C.; Alvarez, R.D.; Huh, W.K.; Lin, Z.; Monie, A.; Hung, C.F.; Wu, T.C. Cluster intradermal DNA vaccination rapidly induces E7-specific CD8+ T-cell immune responses leading to therapeutic antitumor effects. Gene Ther. 2008 Aug;15(16):1156-1166.

    Trimble, C.L. Human papillomavirus vaccination should be offered to young males: Counterpoint. Cancer Epidemiol Biomarkers Prev. 2008 Apr;17(4):809.
    Tseng, C.W.; Hung, C.F.; Alvarez, R.D.; Trimble, C.; Huh, W.K.; Kim, D.; Chuang, C.M.; Lin, C.T.; Tsai, Y.C.; He, L.; Monie, A.; Wu, T.C. Pretreatment with cisplatin enhances E7-specific CD8+ T-Cell-mediated antitumor immunity induced by DNA vaccination. Clin Cancer Res. 2008 May 15;14(10):3185-3192.

    Tseng, C.W.; Monie, A.; Trimble, C.; Alvarez, R.D.; Huh, W.K.; Buchsbaum, D.J.; Straughn, J.M., Jr.; Wang, M.C.; Yagita, H.; Hung, C.F.; Wu, T.C. Combination of treatment with death receptor 5-specific antibody with therapeutic HPV DNA vaccination generates enhanced therapeutic anti-tumor effects. Vaccine. 2008 Aug 12;26(34):4314-4319.

    Tseng, C.W.; Trimble, C.; Zeng, Q.; Monie, A.; Alvarez, R.D.; Huh, W.K.; Hoory, T.; Wang, M.C.; Hung, C.F.; Wu, T.C. Low-dose radiation enhances therapeutic HPV DNA vaccination in tumor-bearing hosts. Cancer Immunol Immunother. 2008 Sep 25.

    Trimble, C.L.; Frazer, I.H. Development of therapeutic HPV vaccines. Lancet Oncol. 2009 Oct;10(10):975-980.

    Trimble, C.L.; Peng, S.; Kos, F.; Gravitt, P.; Viscidi, R.; Sugar, E.; Pardoll, D.; Wu, T.C. A phase I trial of a human papillomavirus DNA vaccine for HPV16+ cervical intraepithelial neoplasia 2/3. Clin Cancer Res. 2009 Jan 1;15(1):361-367.

    Trimble, C.L.; Peng, S.; Thoburn, C.; Kos, F.; Wu, T.C. Naturally occurring systemic immune responses to HPV antigens do not predict regression of CIN2/3. Cancer Immunol Immunother. 2009 Dec 13.

    Tseng, C.W.; Trimble, C.; Zeng, Q.; Monie, A.; Alvarez, R.D.; Huh, W.K.; Hoory, T.; Wang, M.C.; Hung, C.F.; Wu, T.C. Low-dose radiation enhances therapeutic HPV DNA vaccination in tumor-bearing hosts. Cancer Immunol Immunother. 2009 May;58(5):737-748.

    Yen, H.R.; Harris, T.J.; Wada, S.; Grosso, J.F.; Getnet, D.; Goldberg, M.V.; Liang, K.L.; Bruno, T.C.; Pyle, K.J.; Chan, S.L.; Anders, R.A.; Trimble, C.L.; Adler, A.J.; Lin, T.Y.; Pardoll, D.M.; Huang, C.T.; Drake, C.G. Tc17 CD8 T cells: functional plasticity and subset diversity. J Immunol. 2009 Dec 1;183(11):7161-7168.

    Trimble, C.L.; Clark, R.A.; Thoburn, C.; Hanson, N.C.; Tassello, J.; Frosina, D.; Kos, F.; Teague, J.; Jiang, Y.; Barat, N.C.; Jungbluth, A.A. Human papillomavirus 16-associated cervical intraepithelial neoplasia in humans excludes CD8 T cells from dysplastic epithelium. J Immunol. 2010 Dec 1;185(11):7107-7114.

    Trimble, C.L.; Peng, S.; Thoburn, C.; Kos, F.; Wu, T.C. Naturally occurring systemic immune responses to HPV antigens do not predict regression of CIN2/3. Cancer Immunol Immunother. 2010 May;59(5):799-803

    Zaino RJ, Trimble CL, Silverberg S, Kauderer J, Curtin J. Reproducibility of the diagnosis of atypical endometrial hyperplasia (AEH): A Gynecologic Oncology Group (GOG) Study. Cancer 2006; 106(4):804-11.

    Trimble CL, Kauderer J, Silverberg S, Curtin J, Lim PC, Burke JJ, Zaino RJ. Concurrent endometrial carcinoma (EC) in women with a biopsy diagnosis of atypical endometrial hyperplasia (AEH): a Gynecologic Oncology Group (GOG) study. Cancer 2006; 106(4):812-9.

    Trimble CL, Peng S, Kos F, Gravitt P, Viscidi R, Sugar E, Pardoll DM, Wu TC. A phase I trial of human papillomavirus (HPV) DNA vaccine for HPV16+ cervical intraepithelial neoplasia 2/3. Clin Cancer Res 2009; 15(1):361-7.

    Yen HR, Harris TJ, Wata S, Grosso JF, Getnet D, Goldberg MV, Liang KL, Bruno TC, Pyle KJ, Chan SL, Anders RA, Trimble CL, Adler AJ, Lin TY, Pardoll DM, Huang CT, Drake CG. Tc17 CD8 T cells: functional plasticity and subset diversity. J Immunol 2009; 183, 7161-7168.

    Trimble CL, Clark RA, Thoburn C, Hanson NC, Tassello J, Frosina D, Kos F, Teague J, Jiang JE, Barat NC, Jungbluth AA. Human papillomavirus 16-associated cervical intraepithelial neoplasia in humans excludes CD8 T cells from dysplastic epithelium. J Immunol 2010; 185(11):7107-7114

    Chou B, Krill LS, Horton BB, Barat CE, Trimble, CL. Disparities in human papillomavirus vaccine completion among vaccine initiators. Obstet Gynecol 2011; 118(1):14-20.

    Levenback CF, Ali S, Coleman RL, Gold MA, Fowler JM, Judson P, Bell MC, De Geest K, Spirtos N, Potkul RK, Leitao MM, Bakkum-Gamez JN, Rossi EC, Lentz SS, Burke II JJ, Van Le L, Trimble CL. Lymphatic Mapping and Sentinel Lymph Node Biopsy in Women with Squamous Carcinoma of the Vulva: A Gynecologic Oncology Group Study. J Clin Oncol 2012; 30(31):3786-91.

    Wallbillich JJ, Rhodes H, Milbourne A, Munsell M, Frumovitz M, Brown J, Trimble CL, Schmeler KM. Vulvar intraepithelial neoplasia (VIN2/3): comparing clinical outcomes and evaluating risk factors for recurrence. Gynecol Oncol, 2012; 127(2):312-5.

    Coleman RL, Ali S, Levenback CF, Gold MA, Fowler JM, Judson PL, Bell MC, De Geest K, Spirtos NM, Potkul RK, Leitao MM Jr, Bakkum-Gamez JN, Rossi EC, Lentz SS, Burke JJ 2nd, Van Le L, Trimble CL. Is bilateral lymphadenectomy for midline squamous carcinoma of the vulva always necessary? An analysis from Gynecologic Oncology Group (GOG) 173. Gynecol Oncol, 2013; 128:155-159.

    Maldonado L, Teague JE, Morrow MP, Yotova I, Wu TC, Wang C, Desmarais C, Boyer JD, Tycko B, Robins HS, Clark RA, Trimble CL. Intramuscular therapeutic vaccination targeting HPV16 induces T cell responses that localize in mucosal lesions. Sci Transl Med 2014; 6,(221):221ra13.

    Trimble CL, Method M, Leitao M, Lu K, Ioffee O, Hampton M, Higgins R, Zaino R, Mutter GL. Management of endometrial precancers. Obstet Gynecol,; 2012 Nov;120(5):1160-1175.

    Stanley M, Pinto LA, Trimble C. Human papillomavirus vaccines – immune responses. Vaccine 2012 Nov 20; Supple5:F83-7.

    Trimble CL. HPV Infection-Associated Cancers: Next-Generation Technology for Diagnosis and Treatment. Cancer Immunology at the Crossroads series, Cancer Immunol Res, 2014 Oct;2(10):937-942.

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