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Michael Patrick Boyle, M.D.

Photo of Dr. Michael Patrick Boyle, M.D.

Director, Adult Cystic Fibrosis Program


Expertise: Cystic Fibrosis, Adult, Lung Transplant, Pulmonary Disease and Critical Care Medicine

Research Interests: Methicillin-resistant Staph aureus infection in cystic fibrosis; Antibiotic resistant Pseudomonas aeruginosa in cystic fibrosis; Clinical and translational research in cystic fibrosis; Basis of Variability of Severity of Cystic Fibrosis Lung Disease; Treatment of Resistant Bacteria in Cystic Fibrosis; Endocrinologic Issues in Cystic Fibrosis; Therapeutics development for CF; Modifier genes and CF lung disease; Infection control; Cystic fibrosis and bone health more

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The Johns Hopkins Hospital
Appointment Phone: 410-955-3467

600 N. Wolfe Street
Sheikh Zayed Tower
Baltimore, MD 21287 map

Johns Hopkins Bayview Medical Center
Appointment Phone: 410-550-5864

4940 Eastern Avenue
Baltimore, MD 21224 map


Dr. Michael Boyle is an associate professor of medicine at the Johns Hopkins University School of Medicine. His areas of clinical expertise include adult cystic fibrosis, lung transplantation and pulmonary diseases. 

Dr. Boyle serves as the director of the Adult Cystic Fibrosis Program at the Johns Hopkins Cystic Fibrosis Center.

He earned his M.D. from Johns Hopkins. He completed his residency and performed a fellowship in pulmonary and critical care medicine at Johns Hopkins.

His research is focused on clinical trials for the development of new cystic fibrosis therapies. 

Dr. Boyle is currently the vice chair of the CF Foundation’s National CF Therapeutic Development Network and is principal investigator for the International Clinical Trials of VX-809 in F508del homoygotes. He has previously served as chairman of the CF Foundation’s Patient and Family Education Committee and the CF Foundation’s Adult CF Program National Quality Improvement Project. He has been selected as a member of “Best Doctors in America.” more


  • Director, Adult Cystic Fibrosis Program

Departments / Divisions



  • MD, Johns Hopkins University School of Medicine (1991)


  • Johns Hopkins University School of Medicine / Internal Medicine (1994)


  • Johns Hopkins University School of Medicine / Pulmonary and Critical Care Medicine (1999)

Board Certifications

  • American Board of Internal Medicine / Pulmonary Disease (1999, 2009)

Research & Publications

Research Summary

Dr. Boyle’s research is focused on clinical trials for the development of new cystic fibrosis therapies. He is studying modifier genes and cystic fibrosis lung disease, infection control, and cystic fibrosis and bone health.

He recently helped co-author a paper that described a proof-of-concept study in mice whereby the researchers used nanoparticle technology as an inhaled vehicle to deliver targeted therapeutic genes for people with life-threatening lung disorders.

Selected Publications

View all on Pubmed

Boyle MP. "The evidence for long-term benefits of restoration of CFTR function continues to grow." Am J Respir Crit Care Med. 2015 Oct 1;192(7):774-6. doi: 10.1164/rccm.201507-1348ED.

Mastorakos P, da Silva AL, Chisholm J, Song E, Choi WK, Boyle MP, Morales MM, Hanes J, Suk JS. "Highly compacted biodegradable DNA nanoparticles capable of overcoming the mucus barrier for inhaled lung gene therapy." Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):8720-5. doi: 10.1073/pnas.1502281112. Epub 2015 Jun 29.

Wainwright CE, Elborn JS, Ramsey BW, Marigowda G, Huang X, Cipolli M, Colombo C, Davies JC, De Boeck K, Flume PA, Konstan MW, McColley SA, McCoy K, McKone EF, Munck A, Ratjen F, Rowe SM, Waltz D, Boyle MP; TRAFFIC Study Group; TRANSPORT Study Group. "Lumacaftor-Ivacaftor in Patients with Cystic Fibrosis Homozygous for Phe508del CFTR." N Engl J Med. 2015 Jul 16;373(3):220-31. doi: 10.1056/NEJMoa1409547. Epub 2015 May 17.

Boyle MP. "Identifying correlates of self-stigma in adults who stutter: Further establishing the construct validity of the Self-Stigma of Stuttering Scale (4S)." J Fluency Disord. 2015 Mar;43:17-27. doi: 10.1016/j.jfludis.2014.12.002. Epub 2015 Jan 6.

Boyle MP. "Relationships between psychosocial factors and quality of life for adults who stutter." Am J Speech Lang Pathol. 2015 Feb;24(1):1-12. doi: 10.1044/2014_AJSLP-14-0089.

Boyle MP. Psychological characteristics and perceptions of stuttering of adults who stutter with and without support group experience. J Fluency Disord. 2013 Dec;38(4):368-81. doi: 10.1016/j.jfludis.2013.09.001. Epub 2013 Oct 1. PMID: 24331244

Lechtzin N, West N, Allgood S, Wilhelm E, Khan U, Mayer-Hamblett N, Aitken ML, Ramsey BW, Boyle MP, Mogayzel PJ Jr, Goss CH. Rationale and design of a randomized trial of home electronic symptom and lung function monitoring to detect cystic fibrosis pulmonary exacerbations: The early intervention in cystic fibrosis exacerbation (eICE) trial. Contemp Clin Trials. 2013 Nov;36(2):460-9. doi: 10.1016/j.cct.2013.09.004. Epub 2013 Sep 19. PMID: 24055998

Boyle MP. Assessment of stigma associated with stuttering: development and evaluation of the self-stigma of stuttering scale (4S). J Speech Lang Hear Res. 2013 Oct;56(5):1517-29. doi: 10.1044/1092-4388(2013/12-0280). Epub 2013 Jul 9. PMID: 23838992

Blood GW, Blood IM, Coniglio AD, Finke EH, Boyle MP. Familiarity breeds support: speech-language pathologists' perceptions of bullying of students with autism spectrum disorders. J Commun Disord. 2013 Mar-Apr;46(2):169-80. doi: 10.1016/j.jcomdis.2013.01.002. Epub 2013 Jan 31. PMID: 23497960

Thomas JA, Boyle MP, Hunter LW, Tiffany JE. Temperature sensitivity of capillary-driven flow: application to age monitoring devices. J Colloid Interface Sci. 2012 Apr 15;372(1):176-82. doi: 10.1016/j.jcis.2012.01.008. Epub 2012 Jan 20. PMID: 22300654

Blood GW, Blood IM, Tramontana GM, Sylvia AJ, Boyle MP, Motzko GR. Self-reported experience of bullying of students who stutter: relations with life satisfaction, life orientation, and self-esteem. Percept Mot Skills. 2011 Oct;113(2):353-64. PMID: 22185050

Boylan NJ, Suk JS, Lai SK, Jelinek R, Boyle MP, Cooper MJ, Hanes J. Highly compacted DNA nanoparticles with low MW PEG coatings: in vitro, ex vivo and in vivo evaluation. J Control Release. 2012 Jan 10;157(1):72-9. doi: 10.1016/j.jconrel.2011.08.031. Epub 2011 Aug 31. PMID: 21903145

Suk JS, Boylan NJ, Trehan K, Tang BC, Schneider CS, Lin JM, Boyle MP, Zeitlin PL, Lai SK, Cooper MJ, Hanes J. N-acetylcysteine enhances cystic fibrosis sputum penetration and airway gene transfer by highly compacted DNA nanoparticles. Mol Ther. 2011 Nov;19(11):1981-9. doi: 10.1038/mt.2011.160. Epub 2011 Aug 9. PMID: 21829177

Clancy JP, Rowe SM, Accurso FJ, Aitken ML, Amin RS, Ashlock MA, Ballmann M, Boyle MP, Bronsveld I, Campbell PW, De Boeck K, Donaldson SH, Dorkin HL, Dunitz JM, Durie PR, Jain M, Leonard A, McCoy KS, Moss RB, Pilewski JM, Rosenbluth DB, Rubenstein RC, Schechter MS, Botfield M, Ordoñez CL, Spencer-Green GT, Vernillet L, Wisseh S, Yen K, Konstan MW. Results of a phase IIa study of VX-809, an investigational CFTR corrector compound, in subjects with cystic fibrosis homozygous for the F508del-CFTR mutation. Thorax. 2012 Jan;67(1):12-8. doi: 10.1136/thoraxjnl-2011-200393. Epub 2011 Aug 8. PMID: 21825083

Boyle MP. Mindfulness training in stuttering therapy: a tutorial for speech-language pathologists. J Fluency Disord. 2011 Jun;36(2):122-9. doi: 10.1016/j.jfludis.2011.04.005. Epub 2011 Apr 23. PMID: 21664530

Activities & Honors


  • Best Doctors in America
  • Alpha Omega Alpha (AOA), Johns Hopkins Chapter, 2006

Professional Activities

  • Senior Vice President of Therapeutics Development, Cystic Fibrosis Foundation
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