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William H. Westra, M.D.

Photo of Dr. William H. Westra, M.D.

Director, Head and Neck Pathology Laboratory

Professor of Pathology


Expertise: Pathology

Research Interests: Thyroid neoplasia; The molecular-genetic progression of head and neck cancer; Application of molecular genetic techniques to the early detection of head and neck cancers more


The Johns Hopkins Hospital (Main Entrance)

1800 Orleans St.
Sheikh Zayed Tower
Baltimore, MD 21287 map
Phone: 410-955-9790

Johns Hopkins Outpatient Center

601 N. Caroline St.
Baltimore, MD 21287 map


Dr. William Henry Westra is a professor of pathology, oncology and otolaryngology - head and neck surgery and an associate professor of dermatology at the Johns Hopkins University School of Medicine. His areas of clinical expertise include pathology. Dr. Westra serves as the director of the Head and Neck Pathology Laboratory in the Department of Pathology.

Dr. Westra established the Head and Neck Pathology Laboratory in 1995, when he joined the Division of Cardiorespiratory Pathology to take part in clinical studies using molecular biology to detect and diagnose head and neck cancers. Work in this promising area is being tested in several multi-institutional clinical trials. He also initiated the laboratory''s diagnostic service.

He earned his M.D. from the University of Florida College of Medicine, and completed his residency at The Johns Hopkins Hospital. He performed a fellowship in oncologic pathology at Memorial Sloan-Kettering Cancer Center and a chief clinical fellowship in surgical pathology at The Johns Hopkins Hospital.

Dr. Westra's research interests include the application of molecular genetic techniques to the early detection of head and neck cancers.

Dr. Westra is the co-author of Surgical Pathology Dissection, which covers current methods and techniques for the assessment of complex head and neck resections. He directs the Pathology Core Facility for the NIH-funded Specialized Program of Research Excellence (SPORE) in Cancer of the Head and Neck. more


  • Director, Head and Neck Pathology Laboratory
  • Professor of Pathology
  • Associate Professor of Dermatology
  • Professor of Oncology
  • Professor of Otolaryngology - Head and Neck Surgery

Centers & Institutes



  • M.D., University of Florida College of Medicine - Gainesville (Florida) (1990)

Research & Publications

Research Summary

Dr. Westra’s research focuses on the detection of head and neck cancers. He is an expert in tumors of the upper respiratory tract, and is also interested in thyroid pathology. As an investigator for the Johns Hopkins Head and Neck Cancer SPORE, he studies the role of HPV (human papilloma virus) in cancer development and how the virus is transmitted to the upper airway.

Core Facility: Pathology Core Facility, Specialized Program of Research Excellence (SPORE) in Cancer of the Head and Neck

Clinical Trials

Treatment De-Intensification for Squamous Cell Carcinoma of the Oropharynx

Immunologic Responses in HPV-Associated Carcinoma for Patients Receiving Chemoradiation

Selected Publications

  1. Alphs, H.H.; Eisele, D.W.; Westra, W.H. The role of fine needle aspiration in the evaluation of parotid masses. Curr Opin Otolaryngol Head Neck Surg. 2006 Apr;14(2):62-66.
  2. da Motta, A.C.; Tunkel, D.E.; Westra, W.H.; Yousem, D.M. Imaging findings of a hibernoma of the neck. Ajnr. 2006 Sep;27(8):1658-1659.
  3. Dodd, L.E.; Sengupta, S.; Chen, I.H.; den Boon, J.A.; Cheng, Y.J.; Westra, W.; Newton, M.A.; Mittl, B.F.; McShane, L.; Chen, C.J.; Ahlquist, P.; Hildesheim, A. Genes involved in DNA repair and nitrosamine metabolism and those located on chromosome 14q32 are dysregulated in nasopharyngeal carcinoma. Cancer Epidemiol Biomarkers Prev. 2006 Nov;15(11):2216-2225.
  4. Hoque, M.O.; Begum, S.; Topaloglu, O.; Chatterjee, A.; Rosenbaum, E.; Van Criekinge, W.; Westra, W.H.; Schoenberg, M.; Zahurak, M.; Goodman, S.N.; Sidransky, D. Quantitation of promoter methylation of multiple genes in urine DNA and bladder cancer detection. J Natl Cancer Inst. 2006 Jul 19;98(14):996-1004.
  5. Hosler, G.A.; Clark, I.; Zakowski, M.F.; Westra, W.H.; Ali, S.Z. Cytopathologic analysis of thyroid lesions in the pediatric population. Diagnostic cytopathology. 2006 Feb;34(2):101-105.
  6. Hu, S.; Liu, D.; Tufano, R.P.; Carson, K.A.; Rosenbaum, E.; Cohen, Y.; Holt, E.H.; Kiseljak-Vassiliades, K.; Rhoden, K.J.; Tolaney, S.; Condouris, S.; Tallini, G.; Westra, W.H.; Umbricht, C.B.; Zeiger, M.A.; Califano, J.A.; Vasko, V.; Xing, M. Association of aberrant methylation of tumor suppressor genes with tumor aggressiveness and BRAF mutation in papillary thyroid cancer. Int J Cancer. 2006 Nov 15;119(10):2322-2329.
  7. Jiang, W.W.; Rosenbaum, E.; Mambo, E.; Zahurak, M.; Masayesva, B.; Carvalho, A.L.; Zhou, S.; Westra, W.H.; Alberg, A.J.; Sidransky, D.; Koch, W.; Califano, J.A. Decreased mitochondrial DNA content in posttreatment salivary rinses from head and neck cancer patients. Clin Cancer Res. 2006 Mar 1;12(5):1564-1569.
  8. Jiang, W.W.; Zahurak, M.; Goldenberg, D.; Milman, Y.; Park, H.L.; Westra, W.H.; Koch, W.; Sidransky, D.; Califano, J. Increased plasma DNA integrity index in head and neck cancer patients. Int J Cancer. 2006 Dec 1;119(11):2673-2676.
  9. Pai, S.I.; Goldstein, B.J.; Studeman, K.D.; Westra, W.H.; Tufano, R.P. Concurrent sporadic parathyroid adenoma and carcinoma. Am J Otolaryngol. 2006 Sep-Oct;27(5):346-348.
  10. Sengupta, S.; den Boon, J.A.; Chen, I.H.; Newton, M.A.; Dahl, D.B.; Chen, M.; Cheng, Y.J.; Westra, W.H.; Chen, C.J.; Hildesheim, A.; Sugden, B.; Ahlquist, P. Genome-Wide Expression Profiling Reveals EBV-Associated Inhibition of MHC Class I Expression in Nasopharyngeal Carcinoma. Cancer Res. 2006 Aug 15;66(16):7999-8006.
  11. Thunnissen, F.B.; Kerr, K.M.; Brambilla, E.; Comin, C.E.; Franklin, W.A.; Guldhammer, B.; Westra, W.H.; Flieder, D.B. EU-USA pathology panel for uniform diagnosis in randomised controlled trials for HRCT screening of lung cancer. Eur Respir J. 2006 Aug 9;28:1186-1189.
  12. Upadhyay, S.; Liu, C.; Chatterjee, A.; Hoque, M.O.; Kim, M.S.; Engles, J.; Westra, W.; Trink, B.; Ratovitski, E.; Sidransky, D. LKB1/STK11 Suppresses Cyclooxygenase-2 Induction and Cellular Invasion through PEA3 in Lung Cancer. Cancer Res. 2006 Aug 15;66(16):7870-7879.
  13. Westra, W.H.; Sidransky, D. Fluorescence visualization in oral neoplasia: shedding light on an old problem. Clin Cancer Res. 2006 Nov 15;12(22):6594-6597.
  14. Begum, S.; Gillison, M.L.; Nicol, T.L.; Westra, W.H. Detection of human papillomavirus-16 in fine-needle aspirates to determine tumor origin in patients with metastatic squamous cell carcinoma of the head and neck. Clin Cancer Res. 2007 Feb 15;13(4):1186-1191.
  15. D'Souza, G.; Kreimer, A.R.; Viscidi, R.; Pawlita, M.; Fakhry, C.; Koch, W.M.; Westra, W.H.; Gillison, M.L. Case-control study of human papillomavirus and oropharyngeal cancer. N Engl J Med. 2007 May 10;356(19):1944-1956.
  16. Lietman, S.A.; Prescott, N.L.; Hicks, D.G.; Westra, W.H.; Levine, M.A. SH3BP2 Is Rarely Mutated in Exon 9 in Giant Cell Lesions Outside Cherubism. Clin Orthop Relat Res. 2007 Jun;459:22-27.
  17. Liu, C.; Zhou, S.; Begum, S.; Sidransky, D.; Westra, W.H.; Brock, M.; Califano, J.A. Increased expression and activity of repair genes TDP1 and XPF in non-small cell lung cancer. Lung Cancer. 2007 Mar;55(3):303-311.
  18. Mithani, S.K.; Taube, J.M.; Zhou, S.; Smith, I.M.; Koch, W.M.; Westra, W.H.; Califano, J.A. Mitochondrial mutations are a late event in the progression of head and neck squamous cell cancer. Clin Cancer Res. 2007 Aug 1;13(15 Pt 1):4331-4335.
  19. Nayak, C.S.; Carvalho, A.L.; Jeronimo, C.; Henrique, R.; Kim, M.M.; Hoque, M.O.; Chang, S.; Jiang, W.W.; Koch, W.; Westra, W.; Sidransky, D.; Califano, J. Positive correlation of tissue inhibitor of metalloproteinase-3 and death-associated protein kinase hypermethylation in head and neck squamous cell carcinoma. Laryngoscope. 2007 Aug;117(8):1376-1380.
  20. Poeta, M.L.; Manola, J.; Goldwasser, M.A.; Forastiere, A.; Benoit, N.; Califano, J.A.; Ridge, J.A.; Goodwin, J.; Kenady, D.; Saunders, J.; Westra, W.; Sidransky, D.; Koch, W.M. TP53 mutations and survival in squamous-cell carcinoma of the head and neck. N Engl J Med. 2007 Dec 20;357(25):2552-2561.
  21. Shah, K.V.; Westra, W.H. Genital HPVs in the aerodigestive tract: Etiologic association with a subset of oropharyngeal/tonsillar cancers and with recurrent respiratory papillomatosis. Disease markers. 2007;23(4):235-245.
  22. Taube, J.M.; Askin, F.B.; Brock, M.V.; Westra, W. Impact of elastic staining on the staging of peripheral lung cancers. Am J Surg Pathol. 2007 Jun;31(6):953-956.
  23. Westra, W.H. Diagnostic difficulties in the classification and grading of salivary gland tumors. Int J Radiat Oncol Biol Phys. 2007;69(2 Suppl):S49-51.
  24. Zhou, S.; Kachhap, S.; Sun, W.; Wu, G.; Chuang, A.; Poeta, L.; Grumbine, L.; Mithani, S.K.; Chatterjee, A.; Koch, W.; Westra, W.H.; Maitra, A.; Glazer, C.; Carducci, M.; Sidransky, D.; McFate, T.; Verma, A.; Califano, J.A. Frequency and phenotypic implications of mitochondrial DNA mutations in human squamous cell cancers of the head and neck. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7540-7545.
  25. Agrawal, Y.; Koch, W.M.; Xiao, W.; Westra, W.H.; Trivett, A.L.; Symer, D.E.; Gillison, M.L. Oral human papillomavirus infection before and after treatment for human papillomavirus 16-positive and human papillomavirus 16-negative head and neck squamous cell carcinoma. Clin Cancer Res. 2008 Nov 1;14(21):7143-7150.
  26. Begum, S.; Westra, W.H. Basaloid squamous cell carcinoma of the head and neck is a mixed variant that can be further resolved by HPV status. Am J Surg Pathol. 2008;32:1044-1050.
  27. Borowitz, M.; Westra, W.H.; Illei, P.B.; Cooley, L.D.; Kant, J.A.; Sokoll, L.J.; Chan, D.W.; Sanfilippo, F. Pathology and Laboratory Medicine. In: Abeloff; Armitage; Kastan; Niederhuberl, editors. 4th ed, Clinical Oncology. Philadelphia: W.B. Saunders; 2008.
  28. Brait, M.; Begum, S.; Carvalho, A.L.; Dasgupta, S.; Vettore, A.L.; Czerniak, B.; Caballero, O.L.; Westra, W.H.; Sidransky, D.; Hoque, M.O. Aberrant Promoter Methylation of Multiple Genes during Pathogenesis of Bladder Cancer. Cancer Epidemiol Biomarkers Prev. 2008 Oct;17(10):2786-2794.
  29. Carvalho, A.L.; Jeronimo, C.; Kim, M.M.; Henrique, R.; Zhang, Z.; Hoque, M.O.; Chang, S.; Brait, M.; Nayak, C.S.; Jiang, W.W.; Claybourne, Q.; Tokumaru, Y.; Lee, J.; Goldenberg, D.; Garrett-Mayer, E.; Goodman, S.; Moon, C.S.; Koch, W.; Westra, W.H.; Sidransky, D.; Califano, J.A. Evaluation of promoter hypermethylation detection in body fluids as a screening/diagnosis tool for head and neck squamous cell carcinoma. Clin Cancer Res. 2008 Jan 1;14(1):97-107.
  30. Chang, S.S.; Jiang, W.W.; Smith, I.; Poeta, L.M.; Begum, S.; Glazer, C.; Shan, S.; Westra, W.; Sidransky, D.; Califano, J.A. MicroRNA alterations in head and neck squamous cell carcinoma. Int J Cancer. 2008 Dec 15;123(12):2791-2797.
  31. Chuang, A.Y.; Chuang, T.C.; Chang, S.; Zhou, S.; Begum, S.; Westra, W.H.; Ha, P.K.; Koch, W.M.; Califano, J.A. Presence of HPV DNA in convalescent salivary rinses is an adverse prognostic marker in head and neck squamous cell carcinoma. Oral Oncol. 2008 Oct;44(10):915-919.
  32. Fakhry, C.; Westra, W.H.; Li, S.; Cmelak, A.; Ridge, J.A.; Pinto, H.; Forastiere, A.; Gillison, M.L. Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial. J Natl Cancer Inst. 2008 Feb 20;100(4):261-269.
  33. Gillison, M.L.; D'Souza, G.; Westra, W.; Sugar, E.; Xiao, W.; Begum, S.; Viscidi, R. Distinct risk factor profiles for human papillomavirus type 16-positive and human papillomavirus type 16-negative head and neck cancers. J Natl Cancer Inst. 2008 Mar 19;100(6):407-420.
  34. Goldenberg, D.; Begum, S.; Westra, W.H.; Khan, Z.; Sciubba, J.; Pai, S.I.; Califano, J.A.; Tufano, R.P.; Koch, W.M. Cystic lymph node metastasis in patients with head and neck cancer: An HPV-associated phenomenon. Head Neck. 2008 Jul;30(7):898-903.
  35. Hoque, M.O.; Begum, S.; Brait, M.; Jeronimo, C.; Zahurak, M.; Ostrow, K.L.; Rosenbaum, E.; Trock, B.; Westra, W.H.; Schoenberg, M.; Goodman, S.N.; Sidransky, D. Tissue inhibitor of metalloproteinases-3 promoter methylation is an independent prognostic factor for bladder cancer. J Urol. 2008 Feb;179(2):743-747.
  36. Hoque, M.O.; Kim, M.S.; Ostrow, K.L.; Liu, J.; Wisman, G.B.; Park, H.L.; Poeta, M.L.; Jeronimo, C.; Henrique, R.; Lendvai, A.; Schuuring, E.; Begum, S.; Rosenbaum, E.; Ongenaert, M.; Yamashita, K.; Califano, J.; Westra, W.; van der Zee, A.G.; Van Criekinge, W.; Sidransky, D. Genome-wide promoter analysis uncovers portions of the cancer methylome. Cancer Res. 2008 Apr 15;68(8):2661-2670.
  37. Licchesi, J.D.; Westra, W.H.; Hooker, C.M.; Herman, J.G. Promoter hypermethylation of hallmark cancer genes in atypical adenomatous hyperplasia of the lung. Clin Cancer Res. 2008 May 1;14(9):2570-2578.
  38. Licchesi, J.D.; Westra, W.H.; Hooker, C.M.; Machida, E.O.; Baylin, S.B.; Herman, J.G. Epigenetic alteration of Wnt pathway antagonists in progressive glandular neoplasia of the lung. Carcinogenesis. 2008 May;29(5):895-904.
  39. Park, H.L.; Kim, M.S.; Yamashita, K.; Westra, W.; Carvalho, A.L.; Lee, J.; Jiang, W.W.; Baek, J.H.; Liu, J.; Osada, M.; Moon, C.S.; Califano, J.A.; Mori, M.; Sidransky, D. DCC promoter hypermethylation in esophageal squamous cell carcinoma. Int J Cancer. 2008 Jun 1;122(11):2498-2502.
  40. Prasad, N.B.; Somervell, H.; Tufano, R.P.; Dackiw, A.P.; Marohn, M.R.; Califano, J.A.; Wang, Y.; Westra, W.H.; Clark, D.P.; Umbricht, C.B.; Libutti, S.K.; Zeiger, M.A. Identification of genes differentially expressed in benign versus malignant thyroid tumors. Clin Cancer Res. 2008 Jun 1;14(11):3327-3337.
  41. Subhawong, A.P.; Subhawong, T.; Nassar, H.; Kouprina, N.; Begum, S.; Vang, R.; Westra, W.H.; Argani, P. Most Basal-like Breast Carcinomas Demonstrate the Same Rb-/p16+ Immunophenotype as the HPV-related Poorly Differentiated Squamous Cell Carcinomas Which They Resemble Morphologically. Am J Surg Pathol. 2008 Oct 17.
  42. Taube, J.M.; Begum, S.; Shi, C.; Eshleman, J.R.; Westra, W.H. Benign Nodal Nevi Frequently Harbor the Activating V600E BRAF Mutation. Am J Surg Pathol. 2008 Nov 19.
  43. Wang, Y.; Kowalski, J.; Tsai, H.L.; Marik, R.; Prasad, N.; Somervell, H.; Lo, P.K.; Sangenario, L.E.; Dyrskjot, L.; Orntoft, T.F.; Westra, W.H.; Meeker, A.K.; Eshleman, J.R.; Umbricht, C.B.; Zeiger, M.A. Differentiating alternative splice variant patterns of human telomerase reverse transcriptase in thyroid neoplasms. Thyroid. 2008 Oct;18(10):1055-1063.
  44. Westra, W.H.; Taube, J.M.; Poeta, M.L.; Begum, S.; Sidransky, D.; Koch, W.M. Inverse Relationship between Human Papillomavirus-16 Infection and Disruptive p53 Gene Mutations in Squamous Cell Carcinoma of the Head and Neck. Clin Cancer Res. 2008 Jan 15;14(2):366-369.
  45. Zhao, M.; Begum, S.; Ha, P.K.; Westra, W.; Califano, J. Downregulation of RAD17 in head and neck cancer. Head Neck. 2008 Jan;30(1):35-42.
  46. Adelstein, D.J.; Ridge, J.A.; Gillison, M.L.; Chaturvedi, A.K.; D''Souza, G.; Gravitt, P.E.; Westra, W.; Psyrri, A.; Kast, W.M.; Koutsky, L.A.; Giuliano, A.; Krosnick, S.; Trotti, A.; Schuller, D.E.; Forastiere, A.; Ullmann, C.D. Head and neck squamous cell cancer and the human papillomavirus: summary of a National Cancer Institute State of the Science Meeting, November 9-10, 2008, Washington, D.C. Head Neck. 2009 Nov;31(11):1393-1422.
  47. Ostrow, K.L.; Park, H.L.; Hoque, M.O.; Kim, M.S.; Liu, J.; Argani, P.; Westra, W.; Van Criekinge, W.; Sidransky, D. Pharmacologic unmasking of epigenetically silenced genes in breast cancer. Clin Cancer Res. 2009 Feb 15;15(4):1184-1191.
  48. Pai, S.I.; Westra, W.H. Molecular Pathology of Head and Neck Cancer: Implications for Diagnosis, Prognosis, and Treatment. Annu Rev Pathol. 2009 Aug 26;4:49-70.
  49. Poeta, M.L.; Manola, J.; Goldenberg, D.; Forastiere, A.; Califano, J.A.; Ridge, J.A.; Goodwin, J.; Kenady, D.; Saunders, J.; Westra, W.; Sidransky, D.; Koch, W.M. The Ligamp TP53 Assay for Detection of Minimal Residual Disease in Head and Neck Squamous Cell Carcinoma Surgical Margins. Clin Cancer Res. 2009 Dec 15;15(24):7658-7665.
  50. Subhawong, A.P.; Subhawong, T.; Nassar, H.; Kouprina, N.; Begum, S.; Vang, R.; Westra, W.H.; Argani, P. Most basal-like breast carcinomas demonstrate the same Rb-/p16+ immunophenotype as the HPV-related poorly differentiated squamous cell carcinomas which they resemble morphologically. Am J Surg Pathol. 2009 Feb;33(2):163-175.
  51. Ang, K.K.; Harris, J.; Wheeler, R.; Weber, R.; Rosenthal, D.I.; Nguyen-Tan, P.F.; Westra, W.H.; Chung, C.H.; Jordan, R.C.; Lu, C.; Kim, H.; Axelrod, R.; Silverman, C.C.; Redmond, K.P.; Gillison, M.L. Human papillomavirus and survival of patients with oropharyngeal cancer. N Engl J Med. 2010 Jul 1;363(1):24-35.
  52. Bishop, J.A.; Westra, W.H. Plasmablastic lymphoma involving the parotid gland. Head and neck pathology. 2010 Jun;4(2):148-151.
  53. Dasgupta, S.; Koch, R.; Westra, W.H.; Califano, J.A.; Ha, P.K.; Sidransky, D.; Koch, W.M. Mitochondrial DNA mutation in normal margins and tumors of recurrent head and neck squamous cell carcinoma patients. Cancer Prev Res (Phila). 2010 Sep;3(9):1205-1211.
  54. Durr, M.L.; Mydlarz, W.K.; Shao, C.; Zahurak, M.L.; Chuang, A.Y.; Hoque, M.O.; Westra, W.H.; Liegeois, N.J.; Califano, J.A.; Sidransky, D.; Ha, P.K. Quantitative methylation profiles for multiple tumor suppressor gene promoters in salivary gland tumors. PLoS One. 2010;5(5):e10828.
  55. Hoque, M.O.; Brait, M.; Rosenbaum, E.; Poeta, M.L.; Pal, P.; Begum, S.; Dasgupta, S.; Carvalho, A.L.; Ahrendt, S.A.; Westra, W.H.; Sidransky, D. Genetic and epigenetic analysis of erbB signaling pathway genes in lung cancer. J Thorac Oncol. 2010 Dec;5(12):1887-1893.
  56. Loyo, M.; Brait, M.; Kim, M.S.; Ostrow, K.L.; Jie, C.C.; Chuang, A.Y.; Califano, J.A.; Liegeois, N.J.; Begum, S.; Westra, W.H.; Hoque, M.O.; Tao, Q.; Sidransky, D. A survey of methylated candidate tumor suppressor genes in nasopharyngeal carcinoma. Int J Cancer. 2010 May 6.
  57. Loyo, M.; Guerrero-Preston, R.; Brait, M.; Hoque, M.O.; Chuang, A.; Kim, M.S.; Sharma, R.; Liegeois, N.J.; Koch, W.M.; Califano, J.A.; Westra, W.H.; Sidransky, D. Quantitative detection of Merkel cell virus in human tissues and possible mode of transmission. Int J Cancer. 2010 Jun 15;126(12):2991-2996.
  58. Lyford-Pike, S.; Westra, W.H.; Loyo, M.; Peng, S.; Hung, C.F.; Wu, A.A.; Flint, P.W.; Tunkel, D.E.; Saunders, J.R.; Pai, S.I. Differential expression of epidermal growth factor receptor in juvenile and adult-onset recurrent respiratory papillomatosis. Histopathology. 2010 Nov;57(5):768-770.
  59. Marur, S.; D''Souza, G.; Westra, W.H.; Forastiere, A.A. HPV-associated head and neck cancer: a virus-related cancer epidemic. Lancet Oncol. 2010 Aug;11(8):781-789.
  60. Meguid, R.A.; Hooker, C.M.; Harris, J.; Xu, L.; Westra, W.H.; Sherwood, J.T.; Sussman, M.; Cattaneo, S.M., 2nd; Shin, J.; Cox, S.; Christensen, J.; Prints, Y.; Yuan, N.; Zhang, J.; Yang, S.C.; Brock, M.V. Long-term survival outcomes by smoking status in surgical and nonsurgical patients with non-small cell lung cancer: comparing never smokers and current smokers. Chest. 2010 Sep;138(3):500-509.
  61. Nichols, A.C.; Finkelstein, D.M.; Faquin, W.C.; Westra, W.H.; Mroz, E.A.; Kneuertz, P.; Begum, S.; Michaud, W.A.; Busse, P.M.; Clark, J.R.; Rocco, J.W. Bcl2 and human papilloma virus 16 as predictors of outcome following concurrent chemoradiation for advanced oropharyngeal cancer. Clin Cancer Res. 2010 Apr 1;16(7):2138-2146.
  62. Singhi, A.D.; Westra, W.H. Comparison of human papillomavirus in situ hybridization and p16 immunohistochemistry in the detection of human papillomavirus-associated head and neck cancer based on a prospective clinical experience. Cancer. 2010 May 1;116(9):2166-2173.
  63. Wang, C.C.; Friedman, L.; Kennedy, G.C.; Wang, H.; Kebebew, E.; Steward, D.L.; Zeiger, M.A.; Westra, W.H.; Wang, Y.; Khanafshar, E.; Fellegara, G.; Rosai, J.; Livolsi, V.; Lanman, R.B. A Large Multicenter Correlation Study of Thyroid Nodule Cytopathology and Histopathology. Thyroid. 2010 Dec 29.

Westra WH, Baas IO, Hruban RH, Offerhaus GJA, Askin FB, Slebos RJC. K-ras oncogene activation in atypical alveolar hyperplasias of the lung: evidence that K-ras mutations are present at an early stage in the development of lung adenocarcinomas. Cancer Res 56:2224-8, 1996.

Westra WH, Baas IO, Hruban RH, Offerhaus GJA, Askin FB, Slebos RJC. K-ras oncogene activation in atypical alveolar hyperplasias of the lung: evidence that K-ras mutations are present at an early stage in the development of lung adenocarcinomas. Cancer Res 56:2224-8, 1996.

Leong PP, Rezai B, Roch WM, Reed A, Eisele D, Lee D-J, Sidransky D, Jen J,Westra WH. Distinguishing Second Primary Tumors from Lung Metastases in Patients with Head and Neck Squamous Cell Carcinoma. J Natl Cancer Inst 90:972-977, 1998.

Califano J, Westra WH, Koch WM, Meininger G, Reed A, Yip L, Boyle JO, Lonardo F, Sidransky D. Unknown primary head and neck squamous cell carcinoma: Molecular identification of the site of origin. J Natl Cancer Inst 91:599-604, 1999.

Begum S, Gillison ML, Ansari-Lari MA, Shah K, Westra WH. Detection of Human Papillomavirus in Cervical Lymph Nodes: A highly effective strategy for localizing site of tumor origin. Clin Cancer Res 15:6469-6475, 2003.

Cohen Y, Rosenbaum E, Clark DP, Zeiger MA, Umbricht CB, Tufano RP, Sidransky S, Westra WH. Mutational analysis of BRAF in fine needle aspiration biopsies of the thyroid: A potential application for the preoperative assessment of thyroid nodules. Clin Cancer Res 10:2761-2765, 2004.

Activities & Honors


  • Pathology Tissue/Specimen Use Committee, Johns Hopkins University School of Medicine

Professional Activities

  • Section editor, The Archives of Otolaryngology - Head and Neck Surgery
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