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Martin Gilbert Pomper, MD

William R. Brody Professor of Radiology
Professor of Radiology and Radiological Science

See Research on Pubmed

Male
Appointment Phone

410-550-2948

Main Location

Johns Hopkins Bayview Medical Center

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Out-of-State & International Patients +
Out of State Patients

Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

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Call +1-410-502-0773 (7a.m. to 6p.m., EST, Mon-Fri)

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Titles

  • William R. Brody Professor of Radiology
  • Associate Director, Johns Hopkins In Vivo Cellular and Molecular Imaging Center
  • Director, Johns Hopkins Small Animal Imaging Resource
  • Professor of Radiology and Radiological Science
  • Professor of Oncology
  • Professor of Radiation Oncology and Molecular Radiation Sciences

Centers & Institutes

  • Cancer Nanotechnology Excellence, Center of
  • In Vivo Cellular Molecular Imaging Center
  • Sidney Kimmel Comprehensive Cancer Center

Expertise

Diagnostic Radiology

Research Interests

Molecular imaging, particularly of central nervous system processes and cancer; Development of new radiotracers for PET and SPECT for cancer detection; In Vivo and Molecular Imaging; Radiopharmacology; Oncology; Translational Molecular Imaging

Biography

Dr. Martin Pomper is a Professor in the Johns Hopkins Medicine Department of Radiology and Radiological Science. He is also a Professor of Oncology and Radiation Oncology and Molecular Radiation Services. He is an internationally recognized leader in molecular imaging research and develops and implements new imaging agents that target cancer and brain disorders.

He is the inaugural recipient of the William R. Brody Professor of Radiology, a professorship designated for a radiologist physician scientist who excels in translational innovation in imaging.

Dr. Pomper is the Director of the Johns Hopkins Small Animal Imaging Resource and Associate Director of the In Vivo Cellular and Molecular Imaging Center, both funded by the National Cancer Institute to support molecular imaging research.

Dr. Pomper received his undergraduate, graduate (organic chemistry) and medical degrees from the University of Illinois at Urbana-Champaign. His postgraduate medical training was at Johns Hopkins and included internship (Osler Medical Service), residencies (diagnostic radiology and nuclear medicine) and fellowship (neuroradiology). He is board certified in diagnostic radiology and nuclear medicine and has been on the faculty at Johns Hopkins since 1996.

Dr. Pomper’s interests are in the development of new radiopharmaceuticals, optical probes and techniques for molecular imaging of cancer and central nervous system disease. He has numerous patents related to medical imaging, many of which have been licensed, as well as several imaging agents in clinical trials.

He is the immediate past President of the Society of Nuclear Medicines Molecular Imaging Center of Excellence and Editor-in-Chief of the journal Molecular Imaging.

Languages

  • English
  • French

Memberships

Member, Johns Hopkins Vasculitis Center

Clinical Trial Keywords

  • AIDS
  • Dementia
  • MS
  • HIV
  • PSMA

Additional Resources

Additional Resources +
  • Education +

    Training

    • University of Illinois (Urbana IL) (1990)

    Residencies

    • Johns Hopkins University School of Medicine / Diagnostic Radiology and Nuclear Medicine (Baltimore MD) (1995)

    Fellowships

    • Johns Hopkins University School of Medicine / Neuroradiology (Baltimore MD) (1996)

    Certifications

    • American Board of Nuclear Medicine / Nuclear Medicine (2005)
    • American Board of Radiology / Diagnostic Radiology (1995)
  • Research & Publications +

    Research Summary

    Dr. Pomper’s research projects in central nervous system imaging include using positron emission tomography (PET) and advanced magnetic resonance spectroscopy (MRS) techniques to uncover brain metabolic correlates of AIDS dementia; using PET to study molecular (neurotransmitter) and cellular abnormalities in patients with AIDS dementia; and the development of new radiopharmaceuticals for imaging nicotinic and glutamatergic neurotransmission as well as for imaging inflammation.

    In oncology, he focuses on advanced magnetic resonance imaging (MRI) techniques, such as diffusion tensor and amide proton transfer imaging to study brain tumors. In addition, radiopharmaceutical and optical imaging agents are being developed to study prostate cancer, metastatic potential, infection, inflammation and to study the pharmacokinetics of chemotherapeutic agents in vivo. Molecular-genetic imaging of cancer is another priority.

    His research group consists of chemists, physicists, molecular biologists and clinicians working together toward clinical molecular imaging.

    Selected Publications View all on PubMed

    1. Banerjee, S.R., Pullambhatla, M., Byun, Y., Nimmagadda, S., Foss, C.A., Green, G., Fox, J.J., Lupold, S.E., Mease, R.C., Pomper, M.G. “Sequential SPECT and optical imaging of experimental models of prostate cancer with a dual modality inhibitor of the prostate-specific membrane antigen.” Angew. Chem. Int. Edit. 2011, in press.
    2. Bhang, H.-E., Gabrielson, K.L., Laterra, J., Fisher, P.B., Pomper, M.G. “Tumor-specific imaging through progression elevated gene-3 promoter-driven gene expression.” Nat. Med. 17:123-129, 2011.
    3. Banerjee, S.R., Pullambhatla, M., Byun, Y., Nimmagadda, S., Green, G., Fox, J.J., Horti, A., Mease ,R.C., Pomper, M.G. (68) “Ga-labeled inhibitors of Prostate-Specific Membrane Antigen (PSMA) for imaging prostate cancer.” J. Med. Chem. 2010 Jun 22.
    4. Nimmagadda, S., Pullambhatla, M., Stone, K., Green, G., Bhujwalla, Z.M., Pomper, M.G. “Molecular imaging of CXCR4 receptor expression in human cancer xenografts with [64Cu]AMD3100 positron emission tomography.” Cancer Res. 70(10):3935-44, 2010.
    5. Wang, H., Byun, Y., Barinka, C., Pullambhatla, M., Bhang, H.-E., Fox, J.J., Lubkowski, J., Mease, R.C., Pomper, M.G. “Bioisosterism of urea-based GCPII inhibitors: synthesis and structure-activity relationships.” Bioorg. Med. Chem. Lett. 20(1):392-7, 2010.
    6. Zhang, Y., Byun, Y., Ren, Y.R., Liu, J.O., Laterra, J., Pomper, M.G. “Identification of inhibitors of ABCG2 by a bioluminescence imaging-based high-throughput assay.” Cancer Res. 69:5867-75, 2009.
    7. Fu, D,, Tanhehco, Y., Chen, J., Foss, C.A., Fox, J.J., Chong, J.-M., Fukayama, M., Sgouros, G., Kowalski, J.,Pomper, M.G., Ambinder, R.F. “Bortezomib-induced enzyme-targeted radiotherapy in herpesvirus-associated tumors.” Nat. Med. 14:1118-1122, 2008.
    8. Diaz, L.A., Foss, C.A., Thornton, K., Nimmagadda, S., Endres, C.J., Uzuner, O., Seyler, T.M., Ulrich, S.D., Conway, J., Bettegowda, C., Agrawal, N., Cheong, I., Zhang, X., Ladenson, P.W., Vogelstein, B.N., Mont, M.A.,
    9. Zhou, S., Kinzler, K.W., Vogelstein, B., Pomper, M.G. “Imaging of musculoskeletal bacterial infections by [124I]FIAU-PET/CT.” PLoS One 2(10):e1007, 2007. Zhou, J., Neale, J.H., Pomper, M.G., Kozikowski, A.P. “NAAG peptidase inhibitors and their potential for diagnosis and therapy.” Nat. Rev. Drug Discovery 4:1015-26, 2005.
    10. Bettegowda, C., Foss, C.A., Wang, Y., Fox, J., Zhou, S., Kinzler, K., Vogelstein, B., Pomper, M.G. “Imaging bacterial infection in live animals with radiolabeled FIAU.” Proc. Natl. Acad. Sci. USA 102:1145-51150, 2005.

    Lab

    The Johns Hopkins Small Animal Imaging Resource Program (SAIRP) works to generate the confidence necessary to move new cancer therapies to patients. Its ultimate goal is to move small animal imaging science forward to the point where the incorporation of such imaging techniques becomes second nature in the daily practice of cancer researchers.

    Dr. Martin Pomper's Lab

    CORE Facilities

    Small Animal Imaging

  • Academic Affiliations & Courses +
  • Activities & Honors +

    Honors

    William R. Brody Professor of Radiology, 2011

    Professional Activities

    Editor-in-chief, Molecular Imaging

    Past president of the Society, Nuclear Medicine''s Molecular Imaging Center of Excellence

    Neuropsychiatric Lupus Research Grant, 2011

  • Videos & Media +
  • Events +
  • Contact & Locations +

    Locations

    Johns Hopkins Bayview Medical Center
    4940 Eastern Avenue
    Baltimore, MD 21224
    Appointment Phone: 410-550-2948
    Location Map
    The Johns Hopkins Hospital
    600 N. Wolfe Street
    Hospital Main Entrance - Sheikh Zayed Tower
    Baltimore, MD 21287
    Appointment Phone: 410-955-6500
    Location Map

    Department/Division

    • Radiology and Radiological Science

    For Research Inquiries Contact

    Cancer Research Bldg. 2, Room 492,
    1550 Orleans Street,
    Baltimore, MD 21231

    Telephone Number: 410-955-2789
    Fax Number: 443-817-0990

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