Research & Publications +
Molecular imaging research - from synthesis of new imaging agents to clinical translation. General areas include cancer, infection/inflammation and central nervous system disease. Examples of specific projects include imaging of prostate cancer through targeting the prostate-specific membrane antigen (PSMA), general cancer imaging through targeting of the CXCR4 chemokine receptor and use of the progression elevated gene 3 promoter (PEG-Prom). Molecular-genetic imaging. Targeted molecular radiotherapy of virus-associated tumors. Study of mechanisms underlying bioluminescence imaging signal. Chemical and radiochemical synthesis. Positron emission tomography of cancer, infection and neuropsychiatric disease.
Banerjee SR, Pullambhatla M, Byun Y, Nimmagadda S, Green G, Fox JJ, Horti A, Mease RC, Pomper MG. (68)Ga-Labeled Inhibitors of Prostate-Specific Membrane Antigen (PSMA) for Imaging Prostate Cancer. J Med Chem. 2010 [Epub ahead of print]
Nimmagadda S, Pullambhatla M, Stone K, Green G, Bhujwalla ZM, Pomper MG.
Molecular imaging of CXCR4 receptor expression in human cancer xenografts with [64Cu]AMD3100 positron emission tomography. Cancer Res. 2010;70:3935-44.
Wang H, Byun Y, Barinka C, Pullambhatla M, Bhang H-C, Fox JJ, Lubkowski J, Mease RC, Pomper, MG. Bioisosterism of urea-based GCPII inhibitors: synthesis and structure-activity relationships. Bioorg Med Chem Lett 2010;20:392-7.
Endres CJ, Pomper MG, James M, Uzuner O, Hammoud DA, Watkins C, Hilton J, Dannals RF, Kassiou M. Initial evaluation of [11C]DPA-713 in man. J Nucl Med, 2009, 50; 1276-82.
Zhang Y, Byun Y, Ren YR, Liu JO, Laterra J, Pomper MG. Identification of Inhibitors of ABCG2 by A Bioluminescence Imaging-based High-throughput Assay. Cancer Res, 2009, 69; 5867-75.
Fu D, Tanhehco Y, Chen J, Foss CA, Fox JJ, Chong J-M, Fukayama M, Sgouros G, Kowalski J, Pomper MG, Ambinder RF. Bortezomib-induced enzyme-targeted radiotherapy in herpesvirus-associated tumors. Nat Med 2008; 14: 1118-1122.
Banerjee SR, Foss CA, Castanares M, Mease RC, Byun Y, Fox JJ, Hilton J, Lupold S, Kozikowski AP, Pomper MG. Synthesis and evaluation of technetium-99m- and rhenium-labeled inhibitors of the prostate-specific membrane antigen (PSMA). J Med Chem 2008; 51:4504-4517.
Chandran SS, Banerjee SR, Mease RC, Pomper MG, Denmeade SR. Formulation, characterization and in vitro toxicity of docetaxel loaded PSMA-targeted nanoparticles. Cancer Biol Ther 2008; 7:974-982.
Diaz LA, Foss CA, Thornton K, Nimmagadda S, Endres CJ, Uzuner O, Seyler TM, Ulrich SD, Conway J, Bettegowda C, Agrawal N, Cheong I, Zhang X, Ladenson PW, Vogelstein BN, Mont MA, Zhou S, Kinzler KW, Vogelstein B, Pomper MG. Imaging of musculoskeletal bacterial infections by [124I]FIAU-PET/CT. PLoS One 2007; 2:e1007.
Zhou J, Neale JH, Pomper MG, Kozikowski AP. NAAG Peptidase inhibitors and their potential for diagnosis and therapy. Nat Rev Drug Discovery, 2005; 4:1015-26. Pub
Bettegowda, C., Foss, C.A., Wang, Y., Fox, J., Zhou, S., Kinzler, K., Vogelstein, B., and Pomper, M.G. Imaging bacterial infection in live animals with radiolabeled FIAU, Proc. Natl. Acad. Sci. USA 102:1145-51150, 2005