Search the Health Library
Get the facts on diseases, conditions, tests and procedures.
I Want To...
Find a Doctor
I Want To...
Find Research Faculty
Enter the last name, specialty or keyword for your search below.
Ilan Shor Wittstein, M.D.
Assistant Professor of Medicine
Languages: English, Hebrew
Expertise: Acute Coronary Care, Acute Coronary Syndrome, Acute Myocardial Infarction, Cardiac Sarcoidosis, Cardiac Transplant, Cardiology, Cardiomyopathy, Cardiovascular Disease, Congestive Heart Failure, Critical Care Cardiology, Endomyocardial Biopsy, Heart Disease, Heart Failure, Heart Transplant, Hypertrophic Cardiomyopathy, Ischemic Heart Disease, Peripartum Cardiomyopathy, Right Heart Catheterization, Stress Testing, Stress-induced Cardiomyopathy ...read more
Research Interests: Effect of emotional and psychological stress on cardiac function; Stress Cardiomyopathy
Request an Appointment
The Johns Hopkins Hospital (Main Entrance)
Appointment Phone: 443-997-0270
1800 Orleans St.
Sheikh Zayed Tower, Suite 7125T
Baltimore, MD 21287 map
Johns Hopkins Outpatient Center
601 N. Caroline St.
Baltimore, MD 21287 map
Dr. Ilan Wittstein is a cardiologist and the foremost expert in “broken heart syndrome,” also known as stress cardiomyopathy or takotsubo cardiomyopathy. His 2005 article in the New England Journal of Medicine explaining the mechanisms of short-term heart failure after extreme stress introduced this syndrome to the global medical community. Dr. Wittstein has lectured extensively on stress cardiomyopathy, both nationally and internationally, and has appeared in scores of major media stories on national TV and radio networks, in international documentaries, newspapers, magazines and websites. Time Magazine called stress cardiomyopathy one of 2005’s most important medical discoveries. As a result of Dr. Wittstein’s work, Johns Hopkins Hospital has become a referral center for patients diagnosed with this condition.
Dr. Wittstein received his undergraduate degree from Wesleyan University in Connecticut, then completed medical school, residency, and two cardiology fellowships at the Johns Hopkins University School of Medicine. He is an assistant professor of medicine and gives regular lectures and seminars on topics of coronary care. Dr. Wittstein also serves as a peer reviewer for over 20 journals including Lancet, Nature Medicine, New England Journal of Medicine, Journal of the American College of Cardiology and European Heart Journal.
- Assistant Professor of Medicine
- MD, Johns Hopkins University School of Medicine (1990)
- Johns Hopkins University School of Medicine / Internal Medicine (1993)
- Johns Hopkins University School of Medicine / Cardiology (1995)
- Johns Hopkins University School of Medicine / Cardiology (1998)
- American Board of Internal Medicine / Advanced Heart Failure and Transplant Cardiology (2012)
- American Board of Internal Medicine / Cardiovascular Disease (1999, 2012)
Research & Publications
Ilan S. Wittstein; David R. Thiemann; Joao A.C. Lima; Kenneth L. Baughman; Steven P. Schulman; Gary Gerstenblith; Katherine C. Wu; Jeffrey J. Rade; Trinity J. Bivalacqua; Hunter C. Champion. Neurohumoral features of myocardial stunning due to sudden emotional stress. New England Journal of Medicine. 2005;352(6):539-548.
Daniel J Brotman; Sherita H Golden; Ilan S Wittstein. The cardiovascular toll of stress. Lancet. 2007;370(9592):1089-1100.
Jacob Abraham; James O. Mudd; Navin Kapur; Kelly Klein; Hunter C. Champion; Ilan S. Wittstein. Stress Cardiomyopathy After Intravenous Administration of Catecholamines and Beta-Receptor Agonists. Journal of the American College of Cardiology. 2009;53(15):1320-1325.
David B. Bekelman; Edward P. Havranek; Diane M. Becker; Jean S. Kutner; Pamela N. Peterson; Ilan S. Wittstein; Sheldon H. Gottlieb; Traci E. Yamashita; Diane L. Fairclough; Sydney M. Dy. Symptoms, Depression, and Quality of Life in Patients With Heart Failure. Journal of Cardiac Failure. 2007;13(8):643-648.
S. Laowattana; S.L. Zeger; J.A.C. Lima; S.N. Goodman; I.S. Wittstein; S.M. Oppenheimer. Left insular stroke is associated with adverse cardiac outcome. Neurology. 2006;66(4):477-483.
David B. Bekelman; Sydney M. Dy; Diane M. Becker; Ilan S. Wittstein; Danetta E. Hendricks; Traci E. Yamashita; Sheldon H. Gottlieb. Spiritual well-being and depression in patients with heart failure. Journal of General Internal Medicine. 2007;22(4):470-477.
Ryan J Tedford; Anna R Hemnes; Stuart D Russell; Ilan S Wittstein; Mobusher Mahmud; Ari L Zaiman; Stephen C Mathai; David R Thiemann; Paul M Hassoun; Reda E Girgis; et al. PDE5A inhibitor treatment of persistent pulmonary hypertension after mechanical circulatory support. Circulation. Heart failure. 2008;1(4):213-219.
Bettina Heidecker; Edward K. Kasper; Ilan S. Wittstein; Hunter C. Champion; Elayne Breton; Stuart D. Russell; Michelle M. Kittleson; Kenneth L. Baughman; Joshua M. Hare. Transcriptomic biomarkers for individual risk assessment in new-onset heart failure. Circulation. 2008;118(3):238-246.
Xinqi Peng; Fabio A. Recchia; Barry J. Byrne; Ilan S. Wittstein; Roy C. Ziegelstein; David A. Kass. In vitro system to study realistic pulsatile flow and stretch signaling in cultured vascular cells. American Journal of Physiology - Cell Physiology. 2000;279(3 48-3):C797-C805.
Ilan S. Wittstein. Stress cardiomyopathy: A syndrome of catecholamine-mediated myocardial stunning? Cellular and Molecular Neurobiology. 2012;32(5):847-857.
Activities & Honors
- Best Doctors in America, 2007 - 2014
- Baltimore's top cardiologists, Baltimore Magazine, 2014
- Cardiology Fellowship Faculty Teaching Award, Johns Hopkins Hospital, 2010
- Baltimore's top cardiologists, Baltimore Magazine, 2007
- Department of Medicine Housestaff Teaching Award, Johns Hopkins Hospital, 2004
- Henry Strong Denison Award for outstanding basic research, Johns Hopkins University School of Medicine, 1990
- Hawk Prize for innovative research in molecular biology and biochemistry, Wesleyan University, 1985
- Phi Beta Kappa, Wesleyan University, 1999
Videos & Media
Lectures and Presentations
Takotsubo Cardiomyopathy: What have we learned?
Chair, Plenary Session , World Congress of Cardiology , Melbourne, Australia (05/07/2014)
Stress and cardiovascular disease: Evidence for disease pathways
Presentation , Harvard Catalyst Symposium on Stress and Health Disparities , Massachusetts General Hospital, Boston, MA (10/17/2013)
Mongan Institute for Health Policy
Moderator , Scientific Sessions , Los Angeles, CA (11/04/2012)
American Heart Association
Stress Cardiomyopathy in 2012: An Evolving Paradigm
Keynote Speaker , 3rd International Conference on Psychoneurocardiology , Heart & Mind: Psychogenic Cardiovascular Disease , Prato, Italy (09/05/2012)
New Mechanisms from Experimental Models
Poster moderator , 61st Annual Scientific Session , Chicago, IL (03/25/2012)
American College of Cardiology
Broken Heart Syndrome
Presentation , Mace Braxton 2011 Cardiovascular Symposium , Salina, KS (11/18/2011)
Salina Regional Health Center
Stress Cardiomyopathy: A Syndrome of Catecholamine Mediated Myocardial Stunning
Presentation , 10th Symposium on Catecholamines and other Neurotransmitters in Stress , Smolenice, Slovakia (06/26/2011)