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J. Raymond Depaulo, Jr, M.D.

Chairman of Psychiatry and Behavioral Sciences
Professor of Psychiatry and Behavioral Sciences


Appointment Phone


Main Location

The Johns Hopkins Hospital

Out-of-State & International Patients +
Out of State Patients

Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

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International Patients

Call +1-410-502-7683 (7a.m. to 6p.m., EST, Mon-Fri)

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  • Chairman of Psychiatry and Behavioral Sciences
  • Director of Department of Psychiatry and Behavioral Sciences
  • Professor of Psychiatry and Behavioral Sciences

Centers & Institutes



The Johns Hopkins Hospital

Appointment Phone: 410-955-5212

600 N. Wolfe Street
Sheikh Zayed Tower
Baltimore, MD 21287 map
Phone: 410-955-3130


Adult Psychiatry , Affective Disorders, Bipolar Disorder, Depression

Research Interests

Bipolar Disorders, Depression


J. Raymond DePaulo, Jr., MD, is the Psychiatrist-in-Chief at the Johns Hopkins Hopspital and is also one of the world's foremost investigators into the genetic bases of bipolar disorders. He was named the Henry Phipps Professor and Chairman of the Department of Psychiatry and Behavioral Sciences in 2002. As a faculty member in the Department of Psychiatry since 1977, Dr. DePaulo has been an active clinician, teacher, and researcher.

Dr. DePaulo remains an active and sought after clinician. His commitment to teaching and mentoring reflects his optimistic vision of the future of psychiatric research.
His ongoing research includes genetic studies of bipolar disease and unipolar disorder, and combined brain imaging and genetic studies of bipolar families.

In addition to his numerous awards for research, Dr. DePaulo was invited to address the World Economics Forum in Davos, Switzerland, both in 2000 and 2001, about the burden of psychiatric disease on national and global economies.

The author of more then 100 scientific publications, Dr. DePaulo has also co-authored two books written for the general public: How to Cope with Depression and Understanding Depression. more

    Additional Information

  • Education +
    • M.D., Johns Hopkins University School of Medicine (Maryland) (1972)
  • Research & Publications +

    Selected Publications

    Nwulia EA, Miao K, Zandi PP, Mackinnon DF, DePaulo JR, McInnis MG. Genome-wide scan of bipolar II disorder. Bipolar Disord. 6: 580-8, 2007.

    Verma R, Cutler DJ, Holmans P, Knowles JA, Crowe RR, Scheftner WA, Weissman MM, DePaulo JR Jr, Levinson DF, Potash JB. Investigating the role of p11 (S100A10) sequence variation in susceptibility to major depression. American Journal of Medical Genetics (Neuropsychiatric Genetics) 144:1079-82, 2007.

    Potash JB, Buervenich S, Cox NJ, Zandi PP, Akula N, Steele J, Rathe JA, Avramopoulos D, Detera-Wadleigh SD, Gershon ES, DePaulo JR Jr, Feinberg AP, McMahon FJ; NIMH Genetics Initiative Bipolar Disorder Consortium. Gene-based SNP mapping of a psychotic bipolar affective disorder linkage region on 22q12.3: association with HMG2L1 and TOM1. American Journal of Medical Genetics (Neuropsychiatric Genetics). 147: 59-67, 2008.

    Willour VL, Chen H, Toolan J, Belmonte P, Cutler DJ, Goes FS, Zandi PP, Lee RS, Mackinnon DF, Mondimore FM, Schweizer B, Depaulo JR Jr, Gershon ES, McMahon FJ, Potash JB. Family-based association of FKBP5 in bipolar disorder. Mol Psychiatry. 14: 261268, 2009.

    Payne JL, MacKinnon DF, Mondimore FM, McInnis MG, Schweizer B, Zamoiski RB, McMahon FJ, Nurnberger JI Jr, Rice JP, Scheftner W, Coryell W, Berrettini WH, Kelsoe JR, Byerley W, Gershon ES, DePaulo JR, Potash JB. Familial aggregation of postpartum mood symptoms in bipolar disorder pedigrees. Bipolar Disord. 10: 38-44,2008.

    Verma R, Holmans P, Knowles JA, Grover D, Evgrafov OV, Crowe RR, Scheftner WA, Weissman MM, Depaulo JR Jr, Potash JB, Levinson DF. Linkage Disequilibrium Mapping of a Chromosome 15q25-26 Major Depression Linkage Region and Sequencing of NTRK3. Biological Psychiatry. 63:1185-9, 2008.

    Langlieb AM, DePaulo JR, Etiology of depression and implications on work environment. Journal of Occupational Environmental Medicine. 391-5, 2008.

    Barton CD, DePaulo JR, The unrecognized costs of delirium. Nature Clinical Practice Neurology. 4:233, 2008. [Editorial]

    Zandi PP, Belmonte PL, Willour VL, Goes FS, Badner JA, Simpson SG, Gershon ES, McMahon FJ, DePaulo JR
    Potash JB; Association study of Wnt signaling pathway genes in bipolar disorder. Bipolar Disorder Phenome Group; National Institute of Mental Health Genetics Initiative Bipolar Disorder Consortium. Archives of General Psychiatry. 65: 785-93, 2008.

    Nwulia EA, Zandi PP, McInnis MG, DePaulo JR, MacKinnon DF. Rapid switching of mood in families with familial bipolar disorder. Bipolar Disord. 10: 597-606, 2008.

    Payne JL, Klein SR, Zamoiski RB, Zandi PP, Bienvenu OJ, Mackinnon DF, Mondimore FM, Schweizer B, Swartz KL; Premenstrual mood symptoms: study of familiality and personality correlates in mood disorder pedigrees. NIMH Genetics Initiative Bipolar Disorder Consortium, Crowe RP, Scheftner WA, Weissman MM, Levinson DF, DePaulo JR, Potash JB. Archives of Womens Mental Health.12: 27-34, 2009
  • Academic Affiliations & Courses +
  • Activities & Honors +


    • Outstanding New Research, National Depressive and Manic Depressive Association, 1989
    • Alpha Omega Alpha, (elected alumnus chapter), 1991
    • Public Education Award, The 1992 NIMH - D/ART, 1992
    • Harriett and Milton Parker Lecture in Psychiatric Genetics, Ohio State University, 1995
    • SELO Prize, for outstanding research on depression, National Association for Research in Schizophrenia and Depression (NARSAD), 1996
    • Samuel Guze Lecture, Washington University, 2002
    • Research Award, American Foundation for Suicide Prevention, 2007


    • American Foundation for Suicide Prevention
    • Depression and Bipolar Support Association
    • National Association for Research in Schizophrenia and Depression
  • Videos & Media +
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