AIDS-Related Cancers, Bone Marrow Transplant, Epstein-Barr Virus and Cancer, Hematologic Malignancies, Kaposi's Sarcoma, Lymphoma, Lymphoma, Hodgkins Disease, Medical Oncology, Non-Hodgkin's Lymphoma
Lymphoma; Epstein-Barr Virus and Cancer; AIDS Associated Cancers; Kaposi's Sarcoma
Virus-associated tumors are among the most common malignancies in certain populations and certain regions. Thus, Burkitts lymphoma (EBV) and Kaposis sarcoma (KSHV) are common in equatorial Africa,nasopharyngeal carcinoma (EBV) is common in southern Chinese populations or those with southern Chinese origins, and immunoblastic lymphomas (EBV) are common in immunocompromised patients (organ transplant recipients, AIDS patients). New approaches to prevention, diagnosis or treatment might thus directly impact on the worlds cancer problem in an important way.
In addition, these tumors are important as model systems for the development of new approaches. The presence of the viral genome provides a handle for new approaches to analysis or intervention. Thus, many immunotherapies target unidentified antigens, making the measurement of relevant immune responses problematic at best. However, in EBV-associated tumors, the antigens are well defined, and the Ambinder lab and others are defining the epitope-specific cellular immune responses. Thus, interventions designed to alter immune response, whether they be vaccine-based interventions, adoptive immunotherapy interventions, or
pharmacologic interventions may all be assessed in terms of relevant surrogate markers in the case of EBV tumors. In the same way that the treatment of Hodgkins lymphoma with radiotherapy and chemotherapy paved the way for the modern approach to malignancies in general with these modalities, the treatment of EBV-associated tumors including Hodgkins lymphoma may pave the way to the more general use of these