Skip Navigation
Find a Doctor
 
 
 
 

 

Photo of Dr. Gerald Nestadt

Gerald Nestadt, MD

Co-Director OCD Clinic
Professor of Psychiatry and Behavioral Sciences
Male
Appointment Phone

410-955-4838

Main Location

The Johns Hopkins Hospital

View All Locations
Out-of-State & International Patients +
Out of State Patients

Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

Learn more about our out-of-state patient services »

International Patients

Call +1-410-502-0773 (7a.m. to 6p.m., EST, Mon-Fri)

Learn more about our international patient services »

Titles

  • Co-Director OCD Clinic
  • Director, Obsessive-Compulsive Disorder Program
  • Professor of Psychiatry and Behavioral Sciences

Expertise

Adult Psychiatry, Anxiety Disorders, Obsessive-Compulsive Disorders, Personality Disorders, Psychiatry

Research Interests

Epidemiology and genetics: OCD, Personality, schizophrenia; Epidemiology of psychopathology; Genetics of schizophrenia & bipolar disorder

Languages

  • English

Additional Resources

Additional Resources +
  • Education +

    Training

    • Baragwanath Hospital (South Africa) (1976)
    • University of Witwatersrand (Johannesburg 2000) (1975)

    Residencies

    • Johns Hopkins University School of Medicine / Psychiatry (Baltimore MD ) (1980)

    Fellowships

    • Johns Hopkins Bloomberg School of Public Health (Baltimore MD ) (1981)

    Certifications

    • American Board of Psychiatry & Neurology / Psychiatry (1983)
  • Research & Publications +

    Research Summary

    The goal of this research program is to elucidate the causes and pathophysiology of obsessive-compulsive disorder (OCD). The program was initiated in the 1990’s to investigate the genetic etiology of OCD.

    In the OCD Family Study (1996-2001), we evaluated over 800 individuals in 153 families. We found the occurrence of OCD to be six times greater in relatives of OCD cases than in relatives of the control group. Other anxiety disorders, especially agoraphobia and generalized anxiety disorder, also were more prevalent in case families. Segregation analysis provided evidence that genes of major effect are involved in OCD.

    In the OCD Collaborative Genetics Study (2001-2007), we directed a genetics study of OCD in collaboration with five other academic centers in the United States. The collaboration diagnostically evaluated and collected DNA samples from over 200 affected sibling pairs, and completed the first large genome-wide genetic linkage scan of OCD. We found evidence of genetic linkage of OCD to regions on chromosomes 1, 3, 6, 7, and 15. We also found intrafamilial correlation of factor dimensions, especially hoarding behavior, in OCD families. In addition, we found significant linkage of compulsive hoarding behavior to a region on chromosome 14. We have been following up these findings with fine mapping of these regions and family-based association studies of functional candidate genes. This research has been funded by grants from the National Institutes of Health, the OCD Foundation, and the James E. Marshall OCD Foundation.

    In the current OCD Collaborative Genetics Association Study (2007 - ), we and our collaborators at five other academic centers are interviewing and collecting DNA samples from 2000 individuals with OCD and their parents. We will conduct a genome-wide association study to identify even smaller chromosomal regions associated with OCD.

    Our research continues to be funded by the National Institute of Mental Health (NIMH), the James E. Marshall OCD Foundation, and the OC Foundation.

    Selected Publications

    1. Nestadt G, Lan T, Samuels J, Riddle M, Bienvenu OJ 3rd, Liang KY, Hoehn-Saric R, Cullen B, Grados M, Beaty TH, Shugart YY. Complex segregation analysis provides compelling evidence for a major gene underlying obsessive-compulsive disorder and for heterogeneity by sex. Am J Hum Genet. 2000 Dec;67(6):1611-6.
    2. Nestadt G, Samuels J, Riddle M, Bienvenu OJ 3rd, Liang KY, LaBuda M, Walkup J, Grados M, Hoehn-Saric R. A family study of obsessive-compulsive disorder. Arch Gen Psychiatry. 2000 Apr;57(4):358-63.
    3. Fallin MD, Lasseter VK, Wolyniec PS, McGrath JA, Nestadt G, Valle D, Liang KY, Pulver AE. Genomewide Linkage Scan for Schizophrenia Susceptibility Loci among Ashkenazi Jewish Families Shows Evidence of Linkage on Chromosome 10q22. Am J Hum Genet. 2003 Sep;73(3):601-11.
    4. Samuels J, Eaton WW, Bienvenu OJ 3rd, Brown CH, Costa PT Jr, Nestadt G. Prevalence and correlates of personality disorders in a community sample. Br J Psychiatry. 2002 Jun;180:536-42.
    5. Nestadt G, Samuels J, Riddle MA, Liang KY, Bienvenu OJ, Hoehn-Saric R, Grados M, Cullen B. The relationship between obsessive-compulsive disorder and anxiety and affective disorders: results from the Johns Hopkins OCD Family Study. Psychol Med. 2001 Apr;31(3):481-7.
  • Academic Affiliations & Courses +
  • Activities & Honors +
  • Videos & Media +
  • Events +
  • Contact & Locations +

    Locations

    The Johns Hopkins Hospital
    600 N. Wolfe Street
    Hospital Main Entrance - Sheikh Zayed Tower
    Baltimore, MD 21287
    Phone: 410-955-4838
    Appointment Phone: 410-955-4838
    Location Map

    Department/Division

    • Psychiatry and Behavioral Sciences

Is This You? Edit Profile

 
 
 
 

© The Johns Hopkins University, The Johns Hopkins Hospital, and Johns Hopkins Health System. All rights reserved.