Dr. Carter runs the Expectant Management Program for prostate cancer at Johns Hopkins. This program is designed to select men who are thought to have small volume cancers for whom no immediate treatment is a rational management option. In this program, Dr. Carter, together with colleagues at the Brady Urological Institute, is seeking to define the biomarker changes, nuclear structural parameters, genetic profile, and diet/lifestyle factors that may help identify which men with prostate cancer can safely forgo treatment for prostate cancer.
In 1995, Dr. Carter began a large prospective study to evaluate what is now referred to as "active surveillance" for prostate cancer—a program designed to select men who are thought to have small volume cancers that may never need treatment. These men have the option to be carefully monitored as an alternative to immediate surgery. In counseling patients regarding the decision to treat or not, Dr. Carter emphasizes the importance of a man’s unique needs and preferences when deciding on treatment.
Clinical Trial Keywords:
National Institute of Aging (BLSA)
Alam R, Carter HB, Landis P, Epstein JI, Mamawala M. Conditional Probability of Reclassification within an Active Surveillance Program for Prostate Cancer. J Urol. 2015 [Epub ahead of print]
Ko JS, Chalfin H, Trock BJ, Feng Z, Humphreys E, Park SW, Carter HB, Frick KD, Han M. Variability in Medicare Utilization and Payment Among Urologists. Urology 2015 [Epub ahead of print].
Carter HB. Active surveillance for favorable risk prostate cancer. Curr Opin Urol; 2015 [Epub ahead of print].
Matoso A, Hassan O, Petrozzino F, Rao BV, Carter HB, Epstein JI. Radical Prostatectomy Findings in Men on Active Surveillance: Variable Findings Dependent on Reason for Surgery and Entry Criteria. J Urol. 2015 [Epub ahead of print].
Carter HB. Aligning evidence and practice: future research needs to increase utilization of active surveillance for favorable risk prostate cancer. Curr Opin Urol 2015; [Epub ahead of print].
Loeb S, Bjurlin MA, Nicholson J, Tammela TL, Penson DF, Carter HB, Carroll P, Etzioni R. "Overdiagnosis and Overtreatment of Prostate Cancer." Eur Urol. 2014 Jan 9. pii: S0302-2838(13)01490-5. doi: 10.1016/j.eururo.2013.12.062.
Wang CC, Carter HB, Epstein JI. "Value of Transition Zone Biopsy in Active Surveillance of Prostate Cancer." J Urol. 2013 Dec 5. pii: S0022-5347(13)06016-3. doi: 10.1016/j.juro.2013.11.058.
Bonekamp D, Bonekamp S, Mullins JK, Epstein JI, Carter HB, Macura KJ. "Multiparametric magnetic resonance imaging characterization of prostate lesions in the active surveillance population: incremental value of magnetic resonance imaging for prediction of disease reclassification." J Comput Assist Tomogr. 2013 Nov-Dec;37(6):948-56. doi: 10.1097/RCT.0b013e31829ae20a.
Inoue LY, Trock BJ, Partin AW, Carter HB, Etzioni R. "Modeling grade progression in an active surveillance study." Stat Med. 2014 Mar 15;33(6):930-9. doi: 10.1002/sim.6003. Epub 2013 Oct 9.
Patel HD, Feng Z, Landis P, Trock BJ, Epstein JI, Carter HB. "Prostate specific antigen velocity risk count predicts biopsy reclassification for men with very low risk prostate cancer." J Urol. 2014 Mar;191(3):629-37. doi: 10.1016/j.juro.2013.09.029. Epub 2013 Sep 20.