Vaccine therapies for solid tumors; Mechanisms of induction of mouse and human antitumor immune responses
After graduating Magna cum laude from Brandeis University, Dr. Jaffee received her M.D. from New York Medical College. She completed her internship and residency at University of Pittsburgh, Presbyterian-University Hospital, then received NIH Research funding as a Research Fellow at the University of Pittsburgh under the guidance of Fran Finn, Ph.D., Research Director. Dr. Jaffee subsequently completed a three Medical Oncology postdoctoral fellowship came at The Johns Hopkins University School of Medicine in Baltimore, M.D. In 1992, Dr. Jaffee was appointed Assistant Professor of Oncology at the Johns Hopkins University School of Medicine (JHUSOM), as well as Medical Director of the Johns Hopkins Oncology Center Cell Processing and Gene Therapy Facility. In 1995, Dr. Jaffee was appointed to a faculty position in the Graduate Program in Immunology. She currently holds faculty positions in the Graduate Program in Pharmacology, the Graduate Program of Cell and Molecular Medicine, and the Graduate Program in Immunology. She was promoted to Associate Professor in 1997, and to Professor of Oncology in 2002. She is the first recipient of the Dana and Albert Cubby Broccoli Professor of Oncology. Dr. Jaffee has focused her scientific career on the pre-clinical and clinical development of vaccines for the treatment of cancer. Dr. Jaffee has published over 100 peer reviewed papers and more than 30 invited reviews, commentaries or book chapters in this area of research.
Dr. Jaffee currently serves as the Co-Director of the Division of Immunology, and Co-leader of the Gastrointestinal Cancers Program in the Department of Oncology and the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. She is also the Associate Director for Translational Research at the Sidney Kimmel Cancer Center at Johns Hopkins. She established and directs the Johns Hopkins Oncology Center Cell Processing and Gene Therapy cGMP Facility. In 2007, she was appointed a Deputy Director for the Institute for Translational and Clinical Research at JHUSOM. Her role is to develop translational programs and Core Resources to facilitate moving novel concepts into first in man clinical testing. She previously served as Chair of the Clinical Research Committee at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins and served a 4-year term on the NCI Tumor Immunology study section and another 4-year term on the NCI Parent Sub-committee D. Dr. Jaffee is currently serving a 5-year term as a member of the NCI Board of Scientific Counselors, and is also a member of the RAID NCI Program Oversight Committee. Her professional society service has included membership in AACR since 1992 where she has served on a number of program committees and a three-year term on the Women in Cancer Research (WICR) Board. She has been a member of ASCO since 1992 and currently serves on the ASCO grants selection committee. Dr. Jaffee serves on a number of External advisory boards for other cancer centers. She has mentored 21 post-doctoral fellows and 12 graduate students, many of which hold Assistant, Associate, and Professor titles at other leading Universities. Dr. Jaffee holds 6 vaccine patents, has been the Laboratory Principal Investigator on 11 Clinical Studies for which she has been elucidating the immunologic responses to vaccine therapies in patients with pancreatic and breast cancers.