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Arthur Burnett, M.D.

Patrick C. Walsh Professor of Urology
Professor of Urology


Appointment Phone


Main Location

Johns Hopkins Outpatient Center

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Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

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Call +1-410-502-7683 (7a.m. to 6p.m., EST, Mon-Fri)

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  • Patrick C. Walsh Professor of Urology
  • Professor of Urology
  • Professor of Oncology

Centers & Institutes


  • Oncology
  • Urology


Johns Hopkins Outpatient Center

Appointment Phone: 410-955-6100

601 N. Caroline Street
Baltimore, MD 21287 map
Phone: 410-614-3986
Fax: 410-614-3695


Cystocele, Enterocele, Erectile Dysfunction, Male Sexual Dysfunction, Pelvic Floor Disorders, Pelvic Relaxation, Penile Cancer, Penile Deformities, Peyronie's Disease, Prostate Cancer, Rectocele, Scrotal Cancer, Sexual Disorders and Dysfunctions, Stress Incontinence, Urethral Cancer, Urethral Diverticulum, Urethral Fistulas, Urological Oncology, Urology , Urology / Urologic Surgery, Urology, Adult

Research Interests

Urethral cancer; Stress incontinence; Sexual disorders and dysfunctions; Scrotal cancer; Rectocele; Prostate cancer; Peyronie's disease; Penile deformities; Penile cancer; Pelvic relaxation; Pelvic floor disorders; Male sexual dysfunction; Erectile dysfunction; Enterocele; Cystocele; Erection physiology


Dr. Arthur Burnett is a professor of urology at the Johns Hopkins School of Medicine. He is the Patrick C. Walk Professor of Urology. Dr. Burnett is the director of the Male Consultation Clinic at Johns Hopkins Hospital, a clinician-scientist at the James Buchanan Brady Urological Institute, and director of the Basic Science Laboratory in Neurourology at the Johns Hopkins School of Medicine.

Dr. Burnett received his undergraduate degree in biology from Princeton University and his medical degree at the Johns Hopkins University School of Medicine. He completed his internship and residency in surgery, and subsequently residency and fellowship in urology at The Johns Hopkins Hospital. Upon completion of his urology residency, he received an American Foundation of Urologic Disease New Investigator Award to continue research work into the regulatory mechanisms of penile erection. He has maintained an active laboratory in neurourology since that time.

Dr. Burnett is an established expert in the areas of prostate cancer, lower genitourinary tract malignancies (penile, scrotal, and urethral cancers), lower genitourinary tract reconstruction (pelvic trauma and urethral stricture disease), erectile dysfunction and penile abnormalities (including Peyronies disease), and female urology (including urinary incontinence, urethral abnormalities, and prolapsed pelvic structures).

He is an expert prostate cancer surgeon, having performed over 2,000 radical prostatectomies where he has proven his skill at applying a single, minimally invasive 3-inch incision just above the pubic bone to facilitate rapid recovery and cosmesis and using a nerve-sparing technique. He has also developed management approaches to improve postoperative functional outcomes following radical prostatectomy.

Dr. Burnett is recognized for being a world-authority in the science and medicine of erectile dysfunction. He contributed original discoveries of the nitric oxide biochemical mechanisms in erectile tissue, which paved the way for the clinical development of oral medications to treat erectile dysfunction such as Viagra. He has also pioneered work to develop therapies to protect penile nerve function required for improved erectile function recovery after radical prostatectomy.

Dr. Burnett has written more than 150 original peer-reviewed articles, along with numerous additional articles, editorials, and book chapters, relating to his biomedical research and clinical activities. His work has appeared in many prominent journals such as Science, Nature Medicine, Proceedings of the National Academy of Sciences, Journal of Urology, Urology, and Journal of Andrology. He has sat on various advisory committees including the Urology Study Section, National Institutes of Health Center for Scientific Review and FDA Advisory Committee for Reproductive Health Drugs. more

    Additional Information

  • Education +


    • Johns Hopkins University School of Medicine / MD (1988)


    • Johns Hopkins University School of Medicine / Urology (1993)


    • American Board of Urology / Urology (1998, 2007)
  • Research & Publications +

    Research Summary

    Dr. Burnett has led the basic science laboratory in neurourology for the last 10 years. Principal research studies have focused on the neurophysiology of the pelvis along with molecular mechanisms largely specific to nerve regulation of erectile and voiding functions.

    Original discoveries in the laboratory include the description of nitric oxide as the principal neurotransmitter regulating penile erection. This discovery contributed to an understanding of the science of penile erection in the early 1990s from which drugs such as Viagra, Levita and Cialis were developed. The laboratory has continued major studies in the areas of nitric oxide biology in the pelvis as they relate to other erection disorders such as priapism, a condition of prolonged penile erection.

    In the past several years, the laboratory has focused on improving outcomes with radical prostatectomy, particularly as these relate to the recovery of urinary and erectile functions. Primary efforts have gone toward the investigation and development of chemical compounds for application in men undergoing radical prostatectomy in hopes that erectile function will be better preserved. Collaboration with neuroscientists at this institution have established a role for neuroimmunophilins, special proteins localized to nerves which appear to be the receptor molecules for specialized drugs that can be taken to thereby protect the nerves from significant damage. Experimental models in rats with nerve injury leading to erectile dysfunction similar to that occurring in men after radical prostatectomy have been used demonstrating the major potential for drugs based on this pathway to be developed and used in the near future.

    Ongoing projects involve the study of additional drugs that may serve the purpose of recovering penile nerve function in men undergoing radical prostatectomy.


    The basic science laboratory in neurourology, headed by Arthur L. Burnett, M.D., is one of the independent research laboratories within the Brady Urological Institute.

    The laboratory focuses on biological mechanisms of the pelvis as these relate to erectile and voiding dysfunctions primarily. The direction of research aims to understand the neurophysiology as well as vascular physiology of the lower genitourinary tract, with an emphasis on the translational aspect of basic science discoveries relevant to the human condition. Overall, the laboratory is geared toward improving and preserving erectile and voiding dysfunctions that occur as a result of pelvic disorders and consequences from treatment of these disorders.

    Clinical Trials:

    Erythropoietin to Enhance Erection Recovery in Men Following Radical Prostatectomy (EPO)

    Health Interventions in Men Undergoing Radical Prostatectomy (HIM-UP)

    Viberect Penile Vibratory Stimulation to Enhance Recovery of Erectile Function and Urinary Continence Post-Prostatectomy

    Assessment of Penile Vibratory Stimulation Using the Viberect in Men With Mild-Moderate and No Erectile Dysfunction

    Androgen Regulation of Priapism in Sickle Cell Disease

    Clinical Trial Keywords: Erectile Dysfunction

    Selected Publications View all on PubMed

    1. Miner M, Nehra A, Jackson G, Bhasin S, Billups K, Burnett AL, Buvat J, Carson C, Cunningham G, Ganz P, Goldstein I, Guay A, Hackett G, Kloner RA, Kostis JB, Laflamme KE, Montorsi P, Ramsey M, Rosen R, Sadovsky R, Seftel A, Shabsigh R, Vlachopoulos C, Wu F. "All Men with Vasculogenic Erectile Dysfunction Require a Cardiovascular Workup." Am J Med. 2013 Nov 1. pii: S0002-9343(13)00927-3. doi: 10.1016/j.amjmed.2013.10.013.
    2. Rowland DL, Adamski BA, Neal CJ, Myers AL, Burnett AL. "Self-Efficacy as a Relevant Construct in Understanding Sexual Response and Dysfunction." J Sex Marital Ther. 2013 Oct 28.
    3. Chaux A, Munari E, Cubilla AL, Hicks J, Lecksell K, Burnett AL, Netto GJ. "Immunohistochemical Expression of the Mammalian Target of Rapamycin Pathway in Penile Squamous Cell Carcinomas: A Tissue Microarray Study of 112 Cases." Histopathology. 2013 Nov 27. doi: 10.1111/his.12338.
    4. Burnett AL. "Erection Rehabilitation after Radical Prostatectomy: Definite Purpose, Indefinite Strategy." Eur Urol. 2013 Oct 28. pii: S0302-2838(13)01091-9. doi: 10.1016/j.eururo.2013.10.018.
    5. Musicki B, Bivalacqua TJ, Champion HC, Burnett AL. "Sildenafil promotes eNOS activation and inhibits NADPH oxidase in the transgenic sickle cell mouse penis." J Sex Med. 2014 Feb;11(2):424-30. doi: 10.1111/jsm.12391.
  • Academic Affiliations & Courses +
  • Activities & Honors +


    • Eagle Scout, Boy Scouts of America, 1976
    • Order of Merit List, R.O.T.C. Advanced Camp, Fort Bragg, North Carolina, 1983
    • Charles M. Cannon Memorial Prize, Biology Department Thesis Symposium, Princeton University, 1984
    • Distinguished Military Graduate, Princeton University, R.O.T.C. Unit, 1984
    • Summer Research Fellowship Program, Clinical Neurogenetics Branch, National Institute of Mental Health, National Institute of Health, Warren G. Magnuson Clinical Center, 1985
    • First Place, Basic Science, Resident Essay Competition, Mid-Atlantic Section of the American Urological Association, 1992
    • Student Merit Award, American Society of Andrology, 1992
    • Young Investigator Award for Post-Doctoral Investigation, Clinical Science, The Johns Hopkins University School of Medicine, 1992
    • First Place, Laboratory Research, Annual Resident Prize Essay Contest, American Urological Association, 1993
    • Male Reproduction/Urology Prize Paper, American Fertility Society, 1993
    • Second Place, Lapides Annual Essay Contest on Urodynamic and Neurourology Research, American Urological Association, 1993
    • Searle New Investigator Research Award, American Foundation for Urologic Disease, Inc., 1994
    • First Place, Lapides Annual Essay Contest on Urodynamic and Neurourology Research, American Urological Association, 1996
    • Merck Clinician Scientist Award, Merck & Co., 1996
    • Yamanouchi Best Abstract Prize in Impotence, American Urological Association, 1998
    • Fellow, American College of Surgeons, 1999
    • Pfizer Scholar in Urology Award, Pfizer, Inc., 1999
    • Yamanouchi Best Abstract Prize in Impotence, American Urological Association, 2001
    • Emil Tanagho Prize, for Best Innovative Research (co-author), 10th World Congress of the International Society for Sexual and Impotence Research, 2002
    • Jean Francois Ginesti; Prize, for Best Paper on Basic Science on Sexual Medicine (co-author), 11th World Congress of the International Society for Sexual and Impotence Research, 2004
    • Zorgniotti-Newman Prize, for Best Paper on Clinical Research in Sexual Medicine, 12th World Congress of the International Society for Sexual Medicine, 2006
    • First Place Award for Excellence, 27th Annual Jackson Hole Urology Conference, 2007
    • Certificate of Appreciation, American Society of Andrology, 2008
    • Alumni Member, Alpha Omega Alpha Honor Medical Society, 2009
    • Edward J. Stegman CPA Memorial Award (4.0 GPA), Johns Hopkins Carey Business School, 2009
    • Faculty Teaching Award, Department of Urology, 2010


    • National Association for the Advancement of Colored People, 1984
      Baltimore Branch
    • Reserve Officers’ Association of the United States, 1984
    • Sigma XI Scientific Research Society, 1984
    • Medical and Chirurgical Faculty of the State of Maryland, 1985
    • American Medical Association, 1988
    • American Urological Association, 1990
    • Society of Government Service Urologists, 1991
    • American Society of Andrology, 1994
    • Monumental City Medical Society, 1994
    • National Medical Association, 1994
    • Sexual Medicine Society of North America, 1994
    • International Society for Impotence Research, 1996
    • The Society of Black Academic Surgeons, 1997
    • Urodynamics Society, 1997
    • American Urogynecologic Society, 1998
    • The Society of Genitourinary Reconstructive Surgeons, 1998
    • The American College of Surgeons, 1999
    • International Society for the Study of Women’s Sexual Health, 2000
    • American Society for Peripheral Nerve, 2003
    • Society of Urologic Prosthetic Surgeons, 2006
    • The Society of University Urologists, 2006

    Professional Activities

    • Comprehensive Diabetes Center's Advisory Board, Johns Hopkins, 1997
    • Comprehensive Women's Health Center Oversight Committee, Johns Hopkins, 1997
    • Medical Advisory Board, National Kidney Foundation of Maryland, 1997
    • Men's Health Advisory Board, Johns Hopkins, 1998
    • Website Committee, Society for the Study of Impotence, 2000
    • 2003 Program Committee, American Society of Andrology, 2001
    • Chairman, Mid-Atlantic Section of the American Urological Association, 2001 - 2002
      Arrangements Committee
    • Examination Committee, American Board of Urology, 2001
    • Urology Study Section, NIH Center for Scientific Review, 2001 - 2005
    • Advisory Committee for Reproductive Health Drugs, FDA, 2003
    • Postgraduate Course Chairman, American Society of Andrology, 2003
    • Board of Directors, Mid-Atlantic Section of the American Urological Association, 2004 - 2007
    • Executive Council, American Society of Andrology, 2004
    • Prostate Cancer Outcomes Working Group, American Urological Association, 2004 - 2006
    • Board of Directors, Sexual Medicine Society of North America, 2005
    • External Examiner, Jamaican Board of Urology Examination Committee (West Indies University), 2006
    • Prostate Cancer Guideline Update Panel, American Urological Association, 2006
    • Research Council Strategic Workgroup, AUA, 2007
    • Workshop on Advancing Urologic Science and Career Development, NIDDK, 2007
    • Male Circumcision Task Force, American Urological Association , 2008
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