Dr. Burnett has led the basic science laboratory in neurourology for the last 10 years. Principal research studies have focused on the neurophysiology of the pelvis along with molecular mechanisms largely specific to nerve regulation of erectile and voiding functions.
Original discoveries in the laboratory include the description of nitric oxide as the principal neurotransmitter regulating penile erection. This discovery contributed to an understanding of the science of penile erection in the early 1990s from which drugs such as Viagra, Levita and Cialis were developed. The laboratory has continued major studies in the areas of nitric oxide biology in the pelvis as they relate to other erection disorders such as priapism, a condition of prolonged penile erection.
In the past several years, the laboratory has focused on improving outcomes with radical prostatectomy, particularly as these relate to the recovery of urinary and erectile functions. Primary efforts have gone toward the investigation and development of chemical compounds for application in men undergoing radical prostatectomy in hopes that erectile function will be better preserved. Collaboration with neuroscientists at this institution have established a role for neuroimmunophilins, special proteins localized to nerves which appear to be the receptor molecules for specialized drugs that can be taken to thereby protect the nerves from significant damage. Experimental models in rats with nerve injury leading to erectile dysfunction similar to that occurring in men after radical prostatectomy have been used demonstrating the major potential for drugs based on this pathway to be developed and used in the near future.
Ongoing projects involve the study of additional drugs that may serve the purpose of recovering penile nerve function in men undergoing radical prostatectomy.
The basic science laboratory in neurourology, headed by Arthur L. Burnett, M.D., is one of the independent research laboratories within the Brady Urological Institute.
The laboratory focuses on biological mechanisms of the pelvis as these relate to erectile and voiding dysfunctions primarily. The direction of research aims to understand the neurophysiology as well as vascular physiology of the lower genitourinary tract, with an emphasis on the translational aspect of basic science discoveries relevant to the human condition. Overall, the laboratory is geared toward improving and preserving erectile and voiding dysfunctions that occur as a result of pelvic disorders and consequences from treatment of these disorders.
Erythropoietin to Enhance Erection Recovery in Men Following Radical Prostatectomy (EPO)
Health Interventions in Men Undergoing Radical Prostatectomy (HIM-UP)
Viberect Penile Vibratory Stimulation to Enhance Recovery of Erectile Function and Urinary Continence Post-Prostatectomy
Assessment of Penile Vibratory Stimulation Using the Viberect in Men With Mild-Moderate and No Erectile Dysfunction
Androgen Regulation of Priapism in Sickle Cell Disease
Clinical Trial Keywords:
Miner M, Nehra A, Jackson G, Bhasin S, Billups K, Burnett AL, Buvat J, Carson C, Cunningham G, Ganz P, Goldstein I, Guay A, Hackett G, Kloner RA, Kostis JB, Laflamme KE, Montorsi P, Ramsey M, Rosen R, Sadovsky R, Seftel A, Shabsigh R, Vlachopoulos C, Wu F. "All Men with Vasculogenic Erectile Dysfunction Require a Cardiovascular Workup." Am J Med. 2013 Nov 1. pii: S0002-9343(13)00927-3. doi: 10.1016/j.amjmed.2013.10.013.
Rowland DL, Adamski BA, Neal CJ, Myers AL, Burnett AL. "Self-Efficacy as a Relevant Construct in Understanding Sexual Response and Dysfunction." J Sex Marital Ther. 2013 Oct 28.
Chaux A, Munari E, Cubilla AL, Hicks J, Lecksell K, Burnett AL, Netto GJ. "Immunohistochemical Expression of the Mammalian Target of Rapamycin Pathway in Penile Squamous Cell Carcinomas: A Tissue Microarray Study of 112 Cases." Histopathology. 2013 Nov 27. doi: 10.1111/his.12338.
Burnett AL. "Erection Rehabilitation after Radical Prostatectomy: Definite Purpose, Indefinite Strategy." Eur Urol. 2013 Oct 28. pii: S0302-2838(13)01091-9. doi: 10.1016/j.eururo.2013.10.018.
Musicki B, Bivalacqua TJ, Champion HC, Burnett AL. "Sildenafil promotes eNOS activation and inhibits NADPH oxidase in the transgenic sickle cell mouse penis." J Sex Med. 2014 Feb;11(2):424-30. doi: 10.1111/jsm.12391.
Treatments for Male Sexual Dysfunction
Patent # 5,439,938
Methods and devices are taught for regulating penile erection and urethral function. Inhibitors of nitric oxide synthase and precursors of nitric oxide are applied to relax or contract the muscles of the corpus cavernosum and the urethra.
Method for Treating Nerve Injury Caused as a Result of Surgery
Patent # 10/156/735
Methods for treating nerve injury caused as a consequence of surgery, and specifically as a consequence of prostate surgery, or for methods of neuroprotection of penile innervation, by administering a neurotrophic compound to a patient in need thereof