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Grant James Anhalt, M.D.

Professor of Pathology


Appointment Phone


Main Location

The Johns Hopkins Hospital

Out-of-State & International Patients +
Out of State Patients

Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

Learn more about our out-of-state patient services »

International Patients

Call +1-410-502-7683 (7a.m. to 6p.m., EST, Mon-Fri)

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  • Professor of Pathology



The Johns Hopkins Hospital

Appointment Phone: 410-955-5933

600 N. Wolfe Street
Baltimore, MD 21287 map


Autoimmune Skin Diseases, Dermatoimmunology, Dermatology

Research Interests

Autoimmunity; Bullous skin diseases; Pemphigus and Pemphigoid

    Additional Information

  • Education +


    • University of Manitoba Faculty of Medicine / MD (1975)


    • University of Manitoba Faculty of Medicine / Internal Medicine (1977)
    • University of Michigan Medical School / Dermatology (1980)


    • University of Michigan Medical School (1981)


    • American Board of Dermatology / Clin & Lab Dermatologic Immunology (1987)
    • American Board of Dermatology / Dermatology (1980)
  • Research & Publications +

    Selected Publications


    1. Anhalt GJ, et al: Pathogenic effects of bullous pemphigoid autoantibodies on rabbit corneal epithelium. J Clin Invest, 68:1097-1101, 1981.
    2. Anhalt GJ, et al: Induction of pemphigus in neonatal mice by passive transfer of IgG from patients with the disease. New Engl J Med, 306:1189-1196, 1982.
    5. Anhalt GJ, et al: Dexamethasone inhibits plasminogen activator activity in experimental pemphigus in vivo but does not block acantholysis. J Immunol, 136:113-117, 1986.
    6. Anhalt GJ,et al. Defining the role of complement in experimental pemphigus in mice. J Immunol, 137:2835-2840, November, 1986.
    7. Anhalt GJ,et al. Bullous pemphigoid autoantibodies are markers of corneal epithelial hemidesmosomes. Invest Ophth Vis Sci, 28:903-907, 1987.
    8. Morrison L, Labib RS, Zone JJ, Diaz LA, and Anhalt GJ. Herpes gestationis autoantibodies recognize a 180kD epidermal antigen. J Clin Invest, 81:2023-2026, 1988.
    9. Mutasim DF, ..Anhalt GJ: Definition of bullous pemphigoid antibody binding to intracellular and extracellular antigen associated with hemidesmosomes. J Invest Dermatol, 92:225-230, 1989.
    10. Rock B, Anhalt GJ, et al: The pathogenic effect of IgG4 autoantibodies in endemic pemphigus foliaceus. New Eng J Med, 320:1463-1469, 1989.
    13. Robledo MA,... Anhalt GJ. Studies of the relationship of the 230 KD and 180 KD bullous pemphigoid antigens. J Invest Dermatol, 94:908-913, 1990.
    14. Anhalt GJ,et al. Paraneoplastic pemphigus: An autoimmune mucocutaneous disease associated with neoplasia: New Engl J Med, 323:1729-1735, 1990.
    17. Labib RS, Rock B, Robledo MA, Anhalt GJ. The calcium sensitive epitope of pemphigus foliaceus antigen is present on a murine tryptic fragment and constitutes a major antigenic region for human autoantibodies. J Invest Dermatol, 96:144-147, 1991.
    19. Fullerton SH, ..Anhalt GJ. Paraneoplastic pemphigus with immune deposits in bronchial epithelium. JAMA, 267(11):1550-1502, 1992.
    21. Oursler J,.. Anhalt GJ. Human autoantibodies against desmoplakins in paraneoplastic pemphigus. J Clin Invest, 89:1775-1782, 1992.
    26. Casciola-Rosen LA, Anhalt GJ, Rosen A. Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes. J Exp Med, 179:1317-1330, 1994.
    27. Casciola-Rosen LA, Miller DK, Anhalt GJ, Rosen A. Specific cleavage of the 70kDa protein component of the U1 small nuclear ribonucleoprotein is a characteristic biochemical feature of apoptotic cell death. J. Biol. Chem., 269:49;30757 - 30760, 1994.
    29. Williams MA, .. Anhalt GJ. Paraneoplastic bullous stomatitis in a horse. J Am Vet Med Assoc. 207 (3): 331-334, 1995.
    31. Allbritton JI, Nousari HC, and Anhalt GJ. Anti-epiligrin (laminin 5) cicatricial pemphigoid. Br. J. Dermatol. 137:992-996, 1997.
    32. Nousari HC, ..Anhalt GJ. Anti-epiligrin cicatricial pemphigoid with antibodies against the gamma-2 subunit of laminin 5. Arch. Dermatol., 135;173-176, 1999.
    35. Nousari HC, Deterding R, Wojtczack H, Aho S, Uitto J, Hashimoto T, Anhalt GJ. The mechanism of respiratory failure in paraneoplastic pemphigus. New Engl J Med, 340;1406-1410, 1999.
    36. Nousari HC, Anhalt GJ. Pemphigus and Bullous Pemphigoid. The Lancet 354:667-672, 1999.
    37. Anhalt GJ, Nousari HC, Deterding R. The mechanism of respiratory failure in paraneoplastic pemphigus. (Letter). New Engl. J. Med. 341:848, 1999.
    38. Anhalt GJ, Diaz LA. Prospects for autoimmune disease:Research Advances in Pemphigus. JAMA 2001; 285:652-654.
    40. Hoffman MA, Qiao X, Anhalt GJ. CD8+ T lymphocytes in bronchiolitis obliterans, paraneoplastic pemphigus and solitary Castlemans disease. New Engl J Med. 349:407-408, 2003.
    42. Thorne JE, Anhalt GJ, Jabs DA, de la Cruz Z, Green WR. Role of electron microscopy in the diagnosis of ocular mucous membrane pemphigoid. Ophthalmology 2006;113:1651-1656.
    43. Cummins DL, Mimouni D, Tzu J, Owens N, Anhalt GJ, Meyerle JH. Lichenoid Paraneoplastic pemphigus in the absence of detectable autoantibodies. J Amer Acad. Dermatol. 2007:1; 153-9.
    44. Cummins DL, Anhalt GJ, Monahan T, Meyerle JH. Treatment of pyoderma gangrenosum with intravenous immunoglobulin. H Br J Dermatol. 2007 : 157; 1235 - 1239.
    45. Hosler, GA, Leigeois N, Anhalt GJ, Moresi JM. Transformation of gamma/delta T cell lymphoma following 15 years of indolent behavior. J Cutaneous Pathology. 2008: 35; 1063-1067.
    46. Thorne JE, Woreta FA, Jabs DA, Anhalt GJ. Treatment of ocular mucous membrane pemphigoid with immunosuppressive drug therapy. Ophthalmology 2008: 115; 2146 2152.
  • Academic Affiliations & Courses +
  • Activities & Honors +


    • Silver Medal for Original Investigations, American Academy of Dermatology, 1990
    • Best Doctors in America, Woodward White, 1994
    • Americas Top Docs, Castle Connely Guide, 2001
    • American Skin Association Award, for Research in Inflammatory Skin Diseases, 2002
    • Top Docs, Baltimore Magazine, 2002
    • Award for Outstanding Service, International Pemphigus Foundation, 2004
    • Top Docs, Washingtonian Magazine, 2005
    • Top Docs, Baltimore Magazine, 2006
    • Top Docs, Washingtonian Magazine, 2007


    • American Academy of Dermatology
    • American Dermatologic Association
    • American Society for Clinical Investigation
    • Austrian Dermatologic Society
    • Canadian Dermatologic Society
      Leader's Society
    • Dermatology Foundation
    • Society for Investigative Dermatology
  • Videos & Media +
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