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Grant James Anhalt, MD

Professor of Dermatology
Appointment Phone


Main Location

Johns Hopkins Outpatient Center

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Out of State Patients

Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

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International Patients

Call +1-410-502-0773 (7a.m. to 6p.m., EST, Mon-Fri)

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  • Professor of Dermatology
  • Professor of Pathology


Autoimmune Skin Diseases, Dermatoimmunology, Dermatology

Research Interests

Pemphigus and Pemphigoid; Bullous skin diseases; Autoimmunity


  • English


American Society for Clinical Investigation
American Academy of Dermatology
Society for Investigative Dermatology
American Dermatologic Association
Dermatology Foundation - Leader''s Society
Canadian Dermatologic Society (Honorary)
Austrian Dermatologic Society (Honorary)
Additional Resources +
  • Education +


    • University of Manitoba Faculty of Medicine (Winnipeg Manitoba) (1975)


    • University of Michigan Medical School / Dermatology (Ann Arbor MI ) (1980)
    • University of Manitoba Faculty of Medicine / Internal Medicine (Winnipeg Manitoba) (1977)


    • University of Michigan Medical School (Ann Arbor MI ) (1981)


    • American Board of Dermatology / Clin & Lab Dermatologic Immunology (1987)
    • American Board of Dermatology / Dermatology (1980)
  • Research & Publications +

    Selected Publications


    1. Anhalt GJ, et al: Pathogenic effects of bullous pemphigoid autoantibodies on rabbit corneal epithelium. J Clin Invest, 68:1097-1101, 1981.
    2. Anhalt GJ, et al: Induction of pemphigus in neonatal mice by passive transfer of IgG from patients with the disease. New Engl J Med, 306:1189-1196, 1982.
    5. Anhalt GJ, et al: Dexamethasone inhibits plasminogen activator activity in experimental pemphigus in vivo but does not block acantholysis. J Immunol, 136:113-117, 1986.
    6. Anhalt GJ,et al. Defining the role of complement in experimental pemphigus in mice. J Immunol, 137:2835-2840, November, 1986.
    7. Anhalt GJ,et al. Bullous pemphigoid autoantibodies are markers of corneal epithelial hemidesmosomes. Invest Ophth Vis Sci, 28:903-907, 1987.
    8. Morrison L, Labib RS, Zone JJ, Diaz LA, and Anhalt GJ. Herpes gestationis autoantibodies recognize a 180kD epidermal antigen. J Clin Invest, 81:2023-2026, 1988.
    9. Mutasim DF, ..Anhalt GJ: Definition of bullous pemphigoid antibody binding to intracellular and extracellular antigen associated with hemidesmosomes. J Invest Dermatol, 92:225-230, 1989.
    10. Rock B, Anhalt GJ, et al: The pathogenic effect of IgG4 autoantibodies in endemic pemphigus foliaceus. New Eng J Med, 320:1463-1469, 1989.
    13. Robledo MA,... Anhalt GJ. Studies of the relationship of the 230 KD and 180 KD bullous pemphigoid antigens. J Invest Dermatol, 94:908-913, 1990.
    14. Anhalt GJ,et al. Paraneoplastic pemphigus: An autoimmune mucocutaneous disease associated with neoplasia: New Engl J Med, 323:1729-1735, 1990.
    17. Labib RS, Rock B, Robledo MA, Anhalt GJ. The calcium sensitive epitope of pemphigus foliaceus antigen is present on a murine tryptic fragment and constitutes a major antigenic region for human autoantibodies. J Invest Dermatol, 96:144-147, 1991.
    19. Fullerton SH, ..Anhalt GJ. Paraneoplastic pemphigus with immune deposits in bronchial epithelium. JAMA, 267(11):1550-1502, 1992.
    21. Oursler J,.. Anhalt GJ. Human autoantibodies against desmoplakins in paraneoplastic pemphigus. J Clin Invest, 89:1775-1782, 1992.
    26. Casciola-Rosen LA, Anhalt GJ, Rosen A. Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes. J Exp Med, 179:1317-1330, 1994.
    27. Casciola-Rosen LA, Miller DK, Anhalt GJ, Rosen A. Specific cleavage of the 70kDa protein component of the U1 small nuclear ribonucleoprotein is a characteristic biochemical feature of apoptotic cell death. J. Biol. Chem., 269:49;30757 - 30760, 1994.
    29. Williams MA, .. Anhalt GJ. Paraneoplastic bullous stomatitis in a horse. J Am Vet Med Assoc. 207 (3): 331-334, 1995.
    31. Allbritton JI, Nousari HC, and Anhalt GJ. Anti-epiligrin (laminin 5) cicatricial pemphigoid. Br. J. Dermatol. 137:992-996, 1997.
    32. Nousari HC, ..Anhalt GJ. Anti-epiligrin cicatricial pemphigoid with antibodies against the gamma-2 subunit of laminin 5. Arch. Dermatol., 135;173-176, 1999.
    35. Nousari HC, Deterding R, Wojtczack H, Aho S, Uitto J, Hashimoto T, Anhalt GJ. The mechanism of respiratory failure in paraneoplastic pemphigus. New Engl J Med, 340;1406-1410, 1999.
    36. Nousari HC, Anhalt GJ. Pemphigus and Bullous Pemphigoid. The Lancet 354:667-672, 1999.
    37. Anhalt GJ, Nousari HC, Deterding R. The mechanism of respiratory failure in paraneoplastic pemphigus. (Letter). New Engl. J. Med. 341:848, 1999.
    38. Anhalt GJ, Diaz LA. Prospects for autoimmune disease:Research Advances in Pemphigus. JAMA 2001; 285:652-654.
    40. Hoffman MA, Qiao X, Anhalt GJ. CD8+ T lymphocytes in bronchiolitis obliterans, paraneoplastic pemphigus and solitary Castlemans disease. New Engl J Med. 349:407-408, 2003.
    42. Thorne JE, Anhalt GJ, Jabs DA, de la Cruz Z, Green WR. Role of electron microscopy in the diagnosis of ocular mucous membrane pemphigoid. Ophthalmology 2006;113:1651-1656.
    43. Cummins DL, Mimouni D, Tzu J, Owens N, Anhalt GJ, Meyerle JH. Lichenoid Paraneoplastic pemphigus in the absence of detectable autoantibodies. J Amer Acad. Dermatol. 2007:1; 153-9.
    44. Cummins DL, Anhalt GJ, Monahan T, Meyerle JH. Treatment of pyoderma gangrenosum with intravenous immunoglobulin. H Br J Dermatol. 2007 : 157; 1235 - 1239.
    45. Hosler, GA, Leigeois N, Anhalt GJ, Moresi JM. Transformation of gamma/delta T cell lymphoma following 15 years of indolent behavior. J Cutaneous Pathology. 2008: 35; 1063-1067.
    46. Thorne JE, Woreta FA, Jabs DA, Anhalt GJ. Treatment of ocular mucous membrane pemphigoid with immunosuppressive drug therapy. Ophthalmology 2008: 115; 2146 2152.
  • Academic Affiliations & Courses +
  • Activities & Honors +


    American Academy of Dermatology Silver Medal for Original Investigations: Dec, 1990
    Best Doctors in America, Woodward White, 1994 - current
    Americas Top Docs, Castle Connely Guide, 2001 - current
    Top Docs, Baltimore Magazine, 2002 and 2006
    Top Docs, Washingtonian Magazine, 2005 and 2007
    American Skin Association Award for Research in Inflammatory Skin Diseases, May, 2002
    International Pemphigus Foundation Award for Outstanding Service, Sept 2004

  • Videos & Media +
  • Events +
  • Contact & Locations +


    Johns Hopkins Outpatient Center
    601 N. Caroline Street
    8th floor
    Baltimore, MD 21287
    Phone: 410-955-5933
    Appointment Phone: 410-955-5933
    Location Map


    • Dermatology - Dermatologic Immunology

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