Dr. Casella’s research focuses on sickle cell disease, with an emphasis on neurologic complications. One of his current projects uses a non-biased proteomic analysis of plasma samples from the ongoing Pediatric Silent Infarct Transfusion (SIT) Trial from patients with or without sickle cell disease.
Hydroxyurea to Prevent Brain Injury in Sickle Cell Disease (HUPrevent)
Clinical Trial Keywords:
Genetics and proteomics of sickle cell disease, Vaso-occlusive crisis in sickle cell disease, Neurovascular disease in sickle cell disease
Khan J, Takemoto C, Casella J, Streiff M, Nwanko I, and Kim J. "Catheter-directed thrombolysis of inferior vena cava thrombosis in a 13-day old neonate and review of literature." CardioVascular & Interventional Rad, October 2007.
Strouse JJ, Takemoto CM, Keefer JR, Kato GJ, Casella JF. "Corticosteroids and Increased Risk of Readmission after Acute Chest Syndrome in Children with Sickle Cell Disease." Pediatric Blood and Cancer 2007 Sep 11; [Epub ahead of print].
Scothorn, DJ, Price C, Buchanan GR, Shurney W, Schwartz D, Sarniak I, Fallon R, Chu JY, Wang W, Casella JF, Resar L, Berman B, Adamkiewicz T, Hsu L, Ohene-Frempong K, Smith-Whitley K, Mahoney D, Scott JP, Woods G, Watanabe M, and DeBaun MR. "Rates of hospitalization for pain and acute chest syndrome in children with sickle cell anemia after five years or more of blood transfusion therapy following stroke." Manuscript in preparation.
Phillips KL, An P, Boyd JH, Strunk RC, Casella JF, Barton BA, and DeBaun MR. "Major Gene Effect and Additive Familial Pattern of Inheritance of Asthma Exist among Families of Probands with Sickle Cell Anemia and Asthma." Am J Human Biol, April, 2007.
Hulbert ML, Scothorn, DJ, Panepinto JA, Scott JP, Buchanan GR, Sarnaik S, Fallon R, Chu J-Y, Wang W, Casella JF, Resar L, Berman, B, Adamkiewicz T, Hsu LL, Smith-Whitley K, Mahoney D, Woods G, Watanabe M, and DeBaun MR. "Exchange blood transfusion for first overt stroke is associated with a lower risk of subsequent stroke than simple transfusion: a retrospective cohort of 137 children with sickle cell anemia." J Pediatr 149: 710-2, 2006.