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Charles George Drake, M.D., Ph.D.

Co-Director Prostate Cancer Multi-Disciplinary Clinic
Professor of Oncology

Male

Appointment Phone

410-955-8964

Main Location

Johns Hopkins Sidney Kimmel Comprehensive Cancer Center

Out-of-State & International Patients +
Out of State Patients

Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

Learn more about our out-of-state patient services »

International Patients

Call +1-410-502-7683 (7a.m. to 6p.m., EST, Mon-Fri)

Learn more about our international patient services »

Titles

  • Co-Director Prostate Cancer Multi-Disciplinary Clinic
  • Professor of Oncology
  • Professor of Urology

Centers & Institutes

Departments

  • Oncology - Immunology/Hematopoiesis
  • Urology

Locations

Johns Hopkins Sidney Kimmel Comprehensive Cancer Center

Appointment Phone: 410-955-8964

401 N. Broadway
Baltimore, MD 21231 map
Phone: 410-502-7523
Fax: 443-287-4653

Expertise

Medical Oncology

Research Interests

Testicular cancer; Immunotherapy; Bladder cancer; Prostate cancer; Medical oncology; Kidney cancer; General internal medicine; Clinical trials

Biography

Dr. Charles George Drake is an associate professor of oncology, urology and immunology at the Johns Hopkins School of Medicine. He also serves as Co-Director of the Prostate Cancer Multidisciplinary Clinic. His areas of expertise include immunotherapy and the diagnosis and treatment of cancers of the prostate, kidney, bladder and testes.

Dr. Drake graduated with a B.S. in electrical engineering and M.S. in biomedical engineering from Rutgers University in Piscataway, NJ. He then received a Ph.D. in immunology from the National Jewish Center for Immunology, and in 1997 completed an M.D. at the University of Colorado Health Sciences Center. He conducted an internal medicine residency on the Osler Service at Johns Hopkins, and in 2002 he completed a fellowship in medical oncology, also at Johns Hopkins. He joined the Johns Hopkins faculty as an assistant professor in 2002.

Dr. Drake has published extensively, has won numerous awards and honors for his research and scholarship, and holds several patents. He is a diplomate of  Medical Oncology with the American Board of Medical Examiners and a member of the American Association of Immunology, the American Association for Cancer Research and the American Society of Clinical Oncology.

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    Additional Information

  • Education +
    • B.S., Rutgers University (New Jersey) (1985)
    • Ph.D., University of Colorado (Colorado) (1995)
    • M.D., University of Colorado School of Medicine - Denver (Colorado) (1997)
  • Research & Publications +

    Research Summary

    To date, clinical trials of immunotherapy in patients with solid tumors have been somewhat disappointing, with response rates less than would be predicted by standard transplantable models. It seems increasingly unlikely that immunotherapy alone will prove sufficient to control advanced cancer. Thus, the development of combination strategies involving radiation, chemotherapy, and androgen manipulation as well as immune checkpoint blockade is critical to achieve clinical success. Testing a variety of combination approaches is impractical in the clinic but is achievable using a targeted model approach involving transgenic animals that spontaneously develop prostate cancer. The full genetic characterization of the specific T cells rendered unresponsive by cancer forms the scientific basis for this approach, and has the potential to define new molecular targets and pathways to augment vaccine efficacy. Finally, characterization of patients'' immune response to prostate cancer in the presence or absence of vaccination will determine new cellular targets for vaccination. In summary, the Drake laboratory has undertaken an interactive approach in which discoveries in the laboratory guide clinical trial development, and the results of these trials will feed back to the laboratory to further refine and expand the role of immunotherapy approaches for patients with prostate cancer.

    Clinical Trials:

    Phase 3 Clinical Trial for Advanced Stage Prostate Cancer


    Selected Publications View all on PubMed

    1. Zeng J, Harris TJ, Lim M, Drake CG, Tran PT. "Immune Modulation and Stereotactic Radiation: Improving Local and Abscopal Responses." Biomed Res Int. 2013;2013:658126. Epub 2013 Nov 14.
    2. Drake CG, Sharma P, Gerritsen W. "Metastatic castration-resistant prostate cancer: new therapies, novel combination strategies and implications for immunotherapy." Oncogene. 2013 Nov 25. doi: 10.1038/onc.2013.497. [Epub ahead of print].
    3. Drake CG, Lipson EJ, Brahmer JR. "Breathing new life into immunotherapy: review of melanoma, lung and kidney cancer." Nat Rev Clin Oncol. 2014 Jan;11(1):24-37. doi: 10.1038/nrclinonc.2013.208. Epub 2013 Nov 19.
    4. Wada S, Harris TJ, Tryggestad E, Yoshimura K, Zeng J, Yen HR, Getnet D, Grosso JF, Bruno TC, De Marzo AM, Netto GJ, Pardoll DM, DeWeese TL, Wong J, Drake CG. "Combined treatment effects of radiation and immunotherapy: studies in an autochthonous prostate cancer model." Int J Radiat Oncol Biol Phys. 2013 Nov 15;87(4):769-76. doi: 10.1016/j.ijrobp.2013.07.015. Epub 2013 Sep 21
    5. Nirschl CJ, Drake CG. ‘Molecular pathways: coexpression of immune checkpoint molecules: signaling pathways and implications for cancer immunotherapy." Clin Cancer Res. 2013 Sep 15;19(18):4917-24. doi: 10.1158/1078-0432.CCR-12-1972. Epub 2013 Jul 18.
  • Academic Affiliations & Courses +
  • Activities & Honors +

    Honors

    • Deans List, Rutgers University College of Engineering, 1984 - 1985
    • Eta Kappa Nu, Electrical Engineering Honor Society, 1984
    • Award For Outstanding Research, University of Colorado Student Research Forum, 1993 - 1994
    • Scholarship for Graduate Research, Viola Vestal Coulter Foundation, 1993
    • E.E. Osgood Award For Highest Ranked Abstract by a Student, Western Society for Clinical Research, 1994
    • Election to Alpha Omega Alpha Medical Honor Society, 1996
    • Clinical Vignette Award, American College of Physicians Student Abstract Competition, 1997
    • Edward Stoiber Scholar Award for Outstanding Scholarship During All Four Medical School Years, 1997
    • Aventis Fellow, Johns Hopkins Department of Oncology, 2001
    • Damon Runyon-Lilly Clinical Investigator Award, 2004
    • Director's Teaching Award in Clinical Science, the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, 2006
    • Scholar Award, V Foundation, 2006

    Memberships

    • American Association for Cancer Research (AACR)
    • American Association of Immunology (AAI)
    • American Society of Clinical Oncology (ASCO)
    • American College of Physicians, 1997 - 1999

    Professional Activities

    • Diplomate, American Board of Medical Examiners
      Internal Medicine
    • Diplomate, American Board of Medical Examiners
      Medical Oncology
  • Videos & Media +
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