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Charles George Drake, MD

Co-Director Prostate Cancer Multi-Disciplinary Clinic
Associate Professor of Oncology

See Research on Pubmed

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Appointment Phone

410-955-8964

Main Location

Johns Hopkins Sidney Kimmel Comprehensive Cancer Center

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Out-of-State & International Patients +
Out of State Patients

Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

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International Patients

Call +1-410-502-0773 (7a.m. to 6p.m., EST, Mon-Fri)

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Titles

  • Co-Director Prostate Cancer Multi-Disciplinary Clinic
  • Associate Professor of Oncology
  • Assistant Professor of Urology

Centers & Institutes

  • Prostate Cancer Multidisciplinary Clinic
  • Sidney Kimmel Comprehensive Cancer Center

Expertise

Medical Oncology

Research Interests

Bladder cancer; Clinical trials; General internal medicine; Immunotherapy; Kidney cancer; Medical oncology; Prostate cancer; Testicular cancer

Biography

Dr. Charles George Drake is an associate professor of oncology, urology and immunology at the Johns Hopkins School of Medicine. He also serves as Co-Director of the Prostate Cancer Multidisciplinary Clinic. His areas of expertise include immunotherapy and the diagnosis and treatment of cancers of the prostate, kidney, bladder and testes.

Dr. Drake graduated with a B.S. in electrical engineering and M.S. in biomedical engineering from Rutgers University in Piscataway, NJ. He then received a Ph.D. in immunology from the National Jewish Center for Immunology, and in 1997 completed an M.D. at the University of Colorado Health Sciences Center. He conducted an internal medicine residency on the Osler Service at Johns Hopkins, and in 2002 he completed a fellowship in medical oncology, also at Johns Hopkins. He joined the Johns Hopkins faculty as an assistant professor in 2002.

Dr. Drake has published extensively, has won numerous awards and honors for his research and scholarship, and holds several patents. He is a diplomate of  Medical Oncology with the American Board of Medical Examiners and a member of the American Association of Immunology, the American Association for Cancer Research and the American Society of Clinical Oncology.

Languages

  • English

Memberships

American Association of Immunology (AAI)

American Association for Cancer Research (AACR)

American Society of Clinical Oncology (ASCO)

American College of Physicians, 1997-1999

Additional Resources +
  • Education +

    Training

    • University of Colorado School of Medicine (Denver CO ) (1997)
    • University of Colorado at Denver (Denver CO ) (1995)

    Residencies

    • Johns Hopkins University School of Medicine / Medicine (Baltimore MD ) (1999)

    Fellowships

    • Johns Hopkins University School of Medicine / Oncology (Baltimore MD ) (2002)

    Certifications

    • American Board of Internal Medicine / Medical Oncology (2004)
  • Research & Publications +

    Research Summary

    To date, clinical trials of immunotherapy in patients with solid tumors have been somewhat disappointing, with response rates less than would be predicted by standard transplantable models. It seems increasingly unlikely that immunotherapy alone will prove sufficient to control advanced cancer. Thus, the development of combination strategies involving radiation, chemotherapy, and androgen manipulation as well as immune checkpoint blockade is critical to achieve clinical success. Testing a variety of combination approaches is impractical in the clinic but is achievable using a targeted model approach involving transgenic animals that spontaneously develop prostate cancer. The full genetic characterization of the specific T cells rendered unresponsive by cancer forms the scientific basis for this approach, and has the potential to define new molecular targets and pathways to augment vaccine efficacy. Finally, characterization of patients'' immune response to prostate cancer in the presence or absence of vaccination will determine new cellular targets for vaccination. In summary, the Drake laboratory has undertaken an interactive approach in which discoveries in the laboratory guide clinical trial development, and the results of these trials will feed back to the laboratory to further refine and expand the role of immunotherapy approaches for patients with prostate cancer.

    Selected Publications View all on PubMed

    1. Zeng J, Harris TJ, Lim M, Drake CG, Tran PT. “Immune Modulation and Stereotactic Radiation: Improving Local and Abscopal Responses.” Biomed Res Int. 2013;2013:658126. Epub 2013 Nov 14.
    2. Drake CG, Sharma P, Gerritsen W. “Metastatic castration-resistant prostate cancer: new therapies, novel combination strategies and implications for immunotherapy.” Oncogene. 2013 Nov 25. doi: 10.1038/onc.2013.497. [Epub ahead of print].
    3. Drake CG, Lipson EJ, Brahmer JR. “Breathing new life into immunotherapy: review of melanoma, lung and kidney cancer.” Nat Rev Clin Oncol. 2014 Jan;11(1):24-37. doi: 10.1038/nrclinonc.2013.208. Epub 2013 Nov 19.
    4. Wada S, Harris TJ, Tryggestad E, Yoshimura K, Zeng J, Yen HR, Getnet D, Grosso JF, Bruno TC, De Marzo AM, Netto GJ, Pardoll DM, DeWeese TL, Wong J, Drake CG. “Combined treatment effects of radiation and immunotherapy: studies in an autochthonous prostate cancer model.” Int J Radiat Oncol Biol Phys. 2013 Nov 15;87(4):769-76. doi: 10.1016/j.ijrobp.2013.07.015. Epub 2013 Sep 21
    5. Nirschl CJ, Drake CG. ‘Molecular pathways: coexpression of immune checkpoint molecules: signaling pathways and implications for cancer immunotherapy.” Clin Cancer Res. 2013 Sep 15;19(18):4917-24. doi: 10.1158/1078-0432.CCR-12-1972. Epub 2013 Jul 18.

    Clinical Trials

    Phase 3 Clinical Trial for Advanced Stage Prostate Cancer

  • Academic Affiliations & Courses +
  • Activities & Honors +

    Honors

    Scholar Award, V Foundation, 2006

    Director’s Teaching Award in Clinical Science,
the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, 2006

    Damon Runyon-Lilly Clinical Investigator Award, 2004

    Aventis Fellow, Johns Hopkins Department of Oncology, 2001

    Clinical Vignette Award, American College of Physicians Student Abstract Competition, 1997

    Edward Stoiber Scholar Award for Outstanding Scholarship During All Four Medical School Years, 1997

    Election to Alpha Omega Alpha Medical Honor Society, 1996

    E.E. Osgood Award For Highest Ranked Abstract by a Student, Western Society for Clinical Research, 1994

    Award For Outstanding Research,
University of Colorado Student Research Forum, 1993-1994

    Scholarship for Graduate Research, Viola Vestal Coulter Foundation, 1993

    Deans List, Rutgers University College of Engineering, 1984-1985

    Eta Kappa Nu Electrical Engineering Honor Society, 1984

    Professional Activities

    Diplomate, Internal Medicine, American Board of Medical Examiners

    Diplomate, Medical Oncology, American Board of Medical Examiners

  • Videos & Media +
  • Events +
  • Contact & Locations +

    Locations

    Johns Hopkins Sidney Kimmel Comprehensive Cancer Center
    401 N. Broadway
    Baltimore, MD 21231
    Phone: 410-502-7523
    Appointment Phone: 410-955-8964
    Fax: 443-287-4653
    Location Map

    Department/Division

    • Oncology - Immunology/Hematopoiesis
    • Oncology - Prostate Cancer/GU

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