Dr. McDevitt's research focuses on unraveling the acquired genetic and epigenetic changes that lead to poor prognosis myeloid disorders. The long term goals include:
- Identify underlying pathways of deregulation to ultimately allow effective therapeutic targeting.
- Develop more sensitive and accurate biomarkers that improve diagnostic classification and prognostication and can be used in translational clinical trials.
- Apply these findings in early phase clinical trials for patients with accelerating myeloproliferative disorders and mixed myelodysplastic syndrome/myeloproliferative disorders. Of particular current interest are DNA repair pathways and Parp inhibitors.
Key collaborators include Judith Karp, Keith Pratz, James Herman, Alison Moliterno, Doug Smith, Hetty Carraway, Steve Gore, Cliff Takemoto, Scott Kaufmann (Mayo Clinic), and Jaroslaw Maciejewski (Cleveland Clinic).
Jankowska AM, Makishima H, Tiu RV, Szpurka H, Huang Y, Traina F, Visconte V, Sugimoto Y, Prince C, O'Keefe C, Hsi ED, List A, Sekeres MA, Rao A, McDevitt MA, Maciejewski JP. "Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A." Blood. 2011 Oct 6;118(14):3932-41. doi: 10.1182/blood-2010-10-311019. Epub 2011 Aug 9.
Stein BL, Williams DM, O'Keefe C, Rogers O, Ingersoll RG, Spivak JL, Verma A, Maciejewski JP, McDevitt MA, Moliterno AR. "Disruption of the ASXL1 gene is frequent in primary, post-essential thrombocytosis and post-polycythemia vera myelofibrosis, but not essential thrombocytosis or polycythemia vera: analysis of molecular genetics and clinical phenotypes." Haematologica. 2011 Oct;96(10):1462-9. doi: 10.3324/haematol.2011.045591. Epub 2011 Jun 28.
Tiu RV, Gondek LP, O'Keefe CL, Elson P, Huh J, Mohamedali A, Kulasekararaj A, Advani AS, Paquette R, List AF, Sekeres MA, McDevitt MA, Mufti GJ, Maciejewski JP. "Prognostic impact of SNP array karyotyping in myelodysplastic syndromes and related myeloid malignancies." Blood. 2011 Apr 28;117(17):4552-60. doi: 10.1182/blood-2010-07-295857. Epub 2011 Feb 1.